Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Holger, Laux"'
Publikováno v:
ATZ worldwide. 123:26-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704d64716967c6a430ab374322218c27
https://doi.org/10.1007/s38311-021-0702-x
https://doi.org/10.1007/s38311-021-0702-x
Publikováno v:
ATZ - Automobiltechnische Zeitschrift. 123:26-31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc6be6fd8d04941c687529069bf2fd9d
https://doi.org/10.1007/s35148-021-0739-6
https://doi.org/10.1007/s35148-021-0739-6
Autor:
Benjamin Sommer, Christopher J. Farady, Joel Alois Rene Tapparel, Ursula Bodendorf, Edward J. Oakeley, Sandro Nuciforo, Sandrine Romand, Stine Buechmann-Moeller, Holger Laux
Publikováno v:
Biotechnology and Bioengineering. 115:2530-2540
An increasing number of nonantibody format proteins are entering clinical development. However, one of the major hurdles for the production of nonantibody glycoproteins is host cell-related proteolytic degradation, which can drastically impact develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a4a0065d1d9f1e857a74dcef8ee85e
https://doi.org/10.1002/bit.26731
https://doi.org/10.1002/bit.26731
Autor:
Bernd Voedisch, Thomas Jostock, Holger Laux, Tatjana Rauschert, Sandro Nuciforo, Anett Ritter, Mevion Oertli, Sabine Geisse, Axel Schulze
Publikováno v:
Biotechnology and Bioengineering. 114:701-704
Recombinant CHO (Chinese hamster ovary) cell lines producing therapeutic proteins often lose their production capability during long-term cultivation. To ensure that CHO production cell lines can be up-scaled to high-volume bioreactors, labor intensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e88bd1e28ad9efece55cb40f8768935
https://doi.org/10.1002/bit.26181
https://doi.org/10.1002/bit.26181
Autor:
Genevieve Kuntzelmann, Bernd Voedisch, Panagiotis Mantas, Barbara Brannetti, Tatjana Rauschert, Nadine Lageyre, Sabine Geisse, Daniel Piehlmaier, Anett Ritter, Mevion Oertli, Holger Laux, Thomas Jostock
Publikováno v:
Biotechnology and Bioengineering. 113:2433-2442
Recently, we reported that the loss of a telomeric region of chromosome 8 in Chinese Hamster Ovary (CHO) cells correlates with higher recombinant productivities. New cell lines lacking this region, called CHO-C8DEL, showed several advantages during c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ce6fb49e4c9bd3c0be1275315326b2
https://doi.org/10.1002/bit.26009
https://doi.org/10.1002/bit.26009
Autor:
Holger Laux, Thomas Jostock, Anett Ritter, Joerg Schmidt, Burkhard Wilms, Mara Fornaro, Sandrine Romand
Publikováno v:
Biotechnology and Bioengineering. 113:1094-1101
Chinese Hamster Ovary (CHO) cells are widely used for the large-scale production of recombinant biopharmaceuticals. However, attempts to express IGF-1 (a mutated human Insulin-like growth factor 1 Ea peptide (hIGF-1Ea mut)) in CHO cells resulted in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::493d6070e2642b1402f4877569c0c4ed
https://doi.org/10.1002/bit.25877
https://doi.org/10.1002/bit.25877
Autor:
Lorena Urda, Dmytro Mayilo, Samuel H Aeschlimann, Alicia Leone Burr, Erik Splinter, Christian Graf, Hélène Lindecker, Max van Min, Marieke Simonis, Holger Laux, Nora Kappes
Publikováno v:
Biotechnology journal. 14(7)
Early analytical clone screening is important during Chinese hamster ovary (CHO) cell line development of biotherapeutic proteins to select a clonally derived cell line with most favorable stability and product quality. Sensitive sequence confirmatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19d525f917f6ba5ba49bb893b884627
https://pubmed.ncbi.nlm.nih.gov/30793505
https://pubmed.ncbi.nlm.nih.gov/30793505
Autor:
Anett Ritter, Thomas Jostock, Sabine Geisse, Burkhard Wilms, Holger Laux, Johannes Wienberg, Bernd Voedisch
Publikováno v:
Biotechnology and Bioengineering. 113:1084-1093
Chinese Hamster Ovary (CHO) cells are widely used for large scale production of recombinant biopharmaceuticals. Although these cells have been extensively used, a demand to further increase the performance, for example, to facilitate the process of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1375bc89fc530afb6bc1a36935856e45
https://doi.org/10.1002/bit.25876
https://doi.org/10.1002/bit.25876
Autor:
Yingxia Wen, Megan Leong, Avishek Nandi, Andrea Carfi, Claudio Ciferri, Viola Fühner, Irmgard Hofmann, Andrea Gerber, Rachel Gerrein, Holger Laux, Anders Lilja, Axel Schulze
Publikováno v:
Biotechnology and Bioengineering. 112:2505-2515
Human cytomegalovirus (HCMV) causes significant disease worldwide. Multiple HCMV vaccines have been tested in man but only partial protection has been achieved. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the main target of neutralizing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c257d040b67b48afe0702475dce48f37
https://doi.org/10.1002/bit.25670
https://doi.org/10.1002/bit.25670