Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Holger, Jaeschke"'
Autor:
Konrad Patyra, Christoffer Löf, Holger Jaeschke, Hendrik Undeutsch, Huifei Sophia Zheng, Sofia Tyystjärvi, Kamila Puławska, Milena Doroszko, Marcin Chruściel, Britt-Marie Loo, Riikka Kurkijärvi, Fu-Ping Zhang, Chen-Che Jeff Huang, Claes Ohlsson, Andreina Kero, Matti Poutanen, Jorma Toppari, Ralf Paschke, Nafis Rahman, Ilpo Huhtaniemi, Jarmo Jääskeläinen, Jukka Kero
Publikováno v:
Thyroid
BACKGROUND: The human adrenal cortex undergoes several rapid remodeling steps during its lifetime. In rodents, similar remodeling occurs postnatally in the “X-zone” layer through unknown mechanisms. Furthermore, little is known regarding the impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284899e225b5924087284d486b7020d1
https://doi.org/10.1089/thy.2021.0535
https://doi.org/10.1089/thy.2021.0535
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111570 (2014)
Glycoprotein hormone receptors (GPHR) have a large extracellular domain (ECD) divided into the leucine rich repeat (LRR) domain for binding of the glycoprotein hormones and the hinge region (HinR), which connects the LRR domain with the transmembrane
Externí odkaz:
https://doaj.org/article/2327bd3e3b284715b871eb2c52932b52
Autor:
Konrad Patyra, Christoffer Löf, Holger Jaeschke, Hendrik Undeutsch, Huifei Zheng, Sofia Tyystjärvi, Kamila Puławska, Milena Doroszko, Marcin Chruściel, Britt-Marie Loo, Riikka Kurkijärvi, Fu-Ping Zhang, Jeff C.C. Huang, Claes Ohlsson, Andreina Kero, Matti Poutanen, Jorma Toppari, Ralf Paschke, Nafis Rahman, Ilpo Huhtaniemi, Jarmo Jääskeläinen, Jukka Kero
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8da977766100a2e833a0f6aa942197
https://doi.org/10.2139/ssrn.3912543
https://doi.org/10.2139/ssrn.3912543
Autor:
Gunnar Kleinau, Holger Jaeschke, Catherine L Worth, Sandra Mueller, Jorge Gonzalez, Ralf Paschke, Gerd Krause
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9745 (2010)
In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (
Externí odkaz:
https://doaj.org/article/6375b17bcdb04d76b69203b1abe1ceac
Autor:
Ralf Paschke, Fu-Ping Zhang, Christoffer Löf, Holger Jaeschke, Jukka Kero, Matti Poutanen, Jorma Toppari, Meeri Jannari, Kristiina Makkonen, Henriette Undeutsch, Moosa Khalil, Konrad Patyra, Markus Eszlinger
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 28(10)
Constitutively active thyrotropin receptor (TSHR) mutations are the most common etiology of non-autoimmune hyperthyroidism (NAH). Thus far, the functionality of these mutations has been tested in vitro, but the in vivo models are lacking.To understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e272cef38dc54402eff8bb958b3b0d
https://pubmed.ncbi.nlm.nih.gov/30132406
https://pubmed.ncbi.nlm.nih.gov/30132406
Autor:
Konrad, Patyra, Holger, Jaeschke, Christoffer, Löf, Meeri, Jännäri, Suvi T, Ruohonen, Henriette, Undeutsch, Moosa, Khalil, Andreina, Kero, Matti, Poutanen, Jorma, Toppari, Min, Chen, Lee S, Weinstein, Ralf, Paschke, Jukka, Kero
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Thyroid function is controlled by thyroid-stimulating hormone (TSH), which binds to its G protein-coupled receptor [thyroid-stimulating hormone receptor (TSHR)] on thyrocytes. TSHR can potentially couple to all G protein families, but it mainly activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad08e5853b1a9b8582e0ca9763263be1
https://pubmed.ncbi.nlm.nih.gov/29799790
https://pubmed.ncbi.nlm.nih.gov/29799790
Autor:
Meeri Jannari, Holger Jaeschke, Christoffer Löf, Suvi T. Ruohonen, Jorma Toppari, Min Chen, Lee S. Weinstein, Ralf Paschke, Konrad Patyra, Jukka Kero, Henriette Undeutsch
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2096a0291a2168c2d17e87cfab192327
https://doi.org/10.1530/endoabs.49.oc4.2
https://doi.org/10.1530/endoabs.49.oc4.2
Autor:
Marja Ojaniemi, Teemu Kuulasmaa, Jukka Kero, Krista Rantakari, Jaakko Ignatius, Juha-Pekka Pursiheimo, Jorma Toppari, Christoffer Löf, Henriette Undeutsch, Jarmo Jääskeläinen, Markku Laakso, Konrad Patyra, Heike Biebermann, Tuulia Pajunen, Gunnar Kleinau, Taina Mustila, Heiko Krude, Jagadish Vangipurapu, Andreina Kero, Päivi J. Miettinen, Turkka Kirjavainen, Peter Kühnen, Holger Jaeschke
Publikováno v:
Thyroid
Background: Congenital hypothyroidism (CH) is defined as the lack of thyroid hormones at birth. Mutations in at least 15 different genes have been associated with this disease. While up to 20% of CH cases are hereditary, the majority of cases are spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178eb13c0d0bc3c4ff9ae436f667f551
https://pubmed.ncbi.nlm.nih.gov/27373559
https://pubmed.ncbi.nlm.nih.gov/27373559
Autor:
Ralf Paschke, Holger Jaeschke, Rocco Moretti, Marcus Nagel, S. Huth, Vera Hintze, Stefan Kalkhof, J. Schaarschmidt, Jens Meiler, Martin von Bergen
Publikováno v:
Schaarschmidt, J, Nagel, M B M, Huth, S, Jaeschke, H, Moretti, R, Hintze, V, Von Bergen, M, Kalkhof, S, Meiler, J & Paschke, R 2016, ' Rearrangement of the extracellular domain/extracellular loop 1 interface is critical for thyrotropin receptor activation ', Journal of Biological Chemistry, vol. 291, no. 27, pp. 14095-14108 . https://doi.org/10.1074/jbc.M115.709659
The thyroid stimulating hormone receptor (TSHR) is a G protein-coupled receptor (GPCR) with a characteristic large extracellular domain (ECD). TSHR activation is initiated by binding of the hormone ligand TSH to the ECD. How the extracellular binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54740d892db21776e157dcd6b85bcf2e
https://vbn.aau.dk/da/publications/50f79461-a75e-40f8-9f51-d3da9fd1f316
https://vbn.aau.dk/da/publications/50f79461-a75e-40f8-9f51-d3da9fd1f316
Publikováno v:
Endocrinology. 152:3986-3996
The hinge region (HinR) is a variable structure of glycoprotein hormone receptors. Its amino acid composition and length is different for glycoprotein hormone receptors and connects the ligand binding domain with the serpentine domain. The role of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd3d0644375c22a92fceaa2e35b1642
https://doi.org/10.1210/en.2011-1389
https://doi.org/10.1210/en.2011-1389