The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial

Autor: Papp, KV, Rentz, DM, Maruff, P, Sun, C-K, Raman, R, Donohue, MC, Schembri, A, Stark, C, Yassa, MA, Wessels, AM, Yaari, R, Holdridge, KC, Aisen, PS, Sperling, RA

Publikováno v: The journal of prevention of Alzheimer's disease, vol 8, iss 1

BackgroundComputerized cognitive assessments may improve Alzheimer's disease (AD) secondary prevention trial efficiency and accuracy. However, they require validation against standard outcomes and relevant biomarkers.ObjectiveTo assess the feasibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::dcb1c66cb4329da09dbaafd2be282f0a
https://escholarship.org/uc/item/86b5v6t9

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.

Autor: Wagemann O; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Liu H; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Wang G; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Shi X; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Bittner T; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Scelsi MA; F. Hoffmann-La Roche Products Ltd, Welwyn Garden City, United Kingdom., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis., Clifford DB; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Supnet-Bell C; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Santacruz AM; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Aschenbrenner AJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Hassenstab JJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Benzinger TLS; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Gordon BA; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Coalier KA; IQVIA, Durham, North Carolina., Cruchaga C; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Ibanez L; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Perrin RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri., Xiong C; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Li Y; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Lah JJ; Department of Neurology, School of Medicine Emory University, Atlanta, Georgia., Berman SB; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham., van Dyck CH; Alzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut., Galasko D; Department of Neurology, University of California, San Diego., Gauthier S; Department of Neurology & Psychiatry, McGill University, Montréal, Québec, Canada., Hsiung GR; Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Brooks WS; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia., Pariente J; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Mummery CJ; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Day GS; Department of Neurology, Mayo Clinic Florida, Jacksonville., Ringman JM; Department of Neurology, University of Southern California, Los Angeles., Mendez PC; Fundación Para la Lucha Contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina., St George-Hyslop P; Department of Neurology, Columbia University, New York, New York., Fox NC; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Suzuki K; National Defense Medical College, Saitama, Japan., Okhravi HR; Department of Geriatrics, Eastern Virginia Medical School, Norfolk., Chhatwal J; Department of Neurology, Massachusetts General and Brigham & Women's Hospitals, Harvard Medical School, Boston., Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Sims JR; Eli Lilly and Company, Indianapolis, Indiana., Holdridge KC; Eli Lilly and Company, Indianapolis, Indiana., Proctor NK; Eli Lilly and Company, Indianapolis, Indiana., Yaari R; Eli Lilly and Company, Indianapolis, Indiana., Andersen SW; Eli Lilly and Company, Indianapolis, Indiana., Mancini M; Eli Lilly and Company, Indianapolis, Indiana., Llibre-Guerra J; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., McDade E; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.

Publikováno v: JAMA neurology [JAMA Neurol] 2024 Jun 01; Vol. 81 (6), pp. 582-593.

Pre-Randomization Predictors of Study Discontinuation in a Preclinical Alzheimer's Disease Randomized Controlled Trial.

Autor: Raman R; Rema Raman, PhD, Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego, USA, Email: remar@usc.edu., Hussen K, Donohue MC, Ernstrom K, Holdridge KC, Langford O, Molina-Henry DP, Pierce AL, Sims JR, Smith A, Yaari R, Aisen PS, Sperling R, Grill JD

Publikováno v: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2024; Vol. 11 (4), pp. 874-880.

Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies.

Autor: Sperling RA; Reisa A. Sperling, MD, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, reisa@bwh.harvard.edu 617-732-8472., Donohue MC, Rissman RA, Johnson KA, Rentz DM, Grill JD, Heidebrink JL, Jenkins C, Jimenez-Maggiora G, Langford O, Liu A, Raman R, Yaari R, Holdridge KC, Sims JR, Aisen PS

Publikováno v: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2024; Vol. 11 (4), pp. 802-813.

Trial of Solanezumab in Preclinical Alzheimer's Disease.

Autor: Sperling RA; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Donohue MC; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Raman R; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Rafii MS; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Johnson K; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Masters CL; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., van Dyck CH; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Iwatsubo T; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Marshall GA; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Yaari R; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Mancini M; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Holdridge KC; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Case M; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Sims JR; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.)., Aisen PS; From the Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School (R.A.S., G.A.M.), and the Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School (K.J.) - both in Boston; Alzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, San Diego (M.C.D., R.R., M.S.R., P.S.A.); the Florey Institute, University of Melbourne, Melbourne, VIC, Australia (C.L.M.); the Departments of Psychiatry, Neurology, and Neuroscience, Yale School of Medicine, New Haven, CT (C.H.D.); the Department of Neuropathology, Graduate School of Medicine, University of Tokyo, Tokyo (T.I.); and Eli Lilly, Indianapolis (R.Y., M.M., K.C.H., M.C., J.R.S.).

Publikováno v: The New England journal of medicine [N Engl J Med] 2023 Sep 21; Vol. 389 (12), pp. 1096-1107. Date of Electronic Publication: 2023 Jul 17.