Zobrazeno 1 - 10
of 1 450
pro vyhledávání: '"Holdgate A"'
Autor:
Mohamed Ismail, Gareth Davies, Graham Sproat, Tiziana Monteverde, Jonathan Tart, Marta Acebrón-García-de-Eulate, Andrea Gohlke, David Hancock, Santosh Adhikari, Sandra Stefanovic-Barrett, David M Smith, Vikki Flemington, Emma S. Gleave-Hanford, Geoffrey A. Holdgate, Jason G. Kettle, Julian Downward
Publikováno v:
SLAS Discovery, Vol 29, Iss 8, Pp 100197- (2024)
The NanoBiT Biochemical Assay (NBBA) was designed as a biochemical format of the NanoBiT cellular assay, aiming to screen weak protein-protein interactions (PPIs) in mammalian cell lysates. Here we present a High Throughput Screening (HTS) applicatio
Externí odkaz:
https://doaj.org/article/ce753bb5efca48b380631a1a108578b9
Autor:
Lillie E. Bell, Catherine Bardelle, Martin J Packer, Johanna Kastl, Geoffrey A. Holdgate, Gareth Davies
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100162- (2024)
Targeted protein degradation is an important mechanism carried out by the cellular machinery, one that is gaining momentum as an exploitable strategy for the development of drug-like compounds. Molecules which are able to induce proximity between elu
Externí odkaz:
https://doaj.org/article/87c376105ba44a24bea894a2940bb6bd
Autor:
Ismail, Mohamed, Davies, Gareth, Sproat, Graham, Monteverde, Tiziana, Tart, Jonathan, Acebrón-García-de-Eulate, Marta, Gohlke, Andrea, Hancock, David, Adhikari, Santosh, Stefanovic-Barrett, Sandra, Smith, David M, Flemington, Vikki, Gleave-Hanford, Emma S., Holdgate, Geoffrey A., Kettle, Jason G., Downward, Julian
Publikováno v:
In SLAS Discovery December 2024 29(8)
Autor:
Ashraf, S. Neha, Blackwell, J. Henry, Holdgate, Geoffrey A., Lucas, Simon C.C., Solovyeva, Alisa, Storer, R. Ian, Whitehurst, Benjamin C.
Publikováno v:
In Drug Discovery Today October 2024 29(10)
Publikováno v:
In Palaeogeography, Palaeoclimatology, Palaeoecology 1 September 2024 649
Autor:
Bell, Lillie E., Bardelle, Catherine, Packer, Martin J, Kastl, Johanna, Holdgate, Geoffrey A., Davies, Gareth
Publikováno v:
In SLAS Discovery July 2024 29(5)
Autor:
Alice Lanne, Catherine Bardelle, Gareth Davies, Antonia Turberville, Hannah Semple, Rachel Moore, Geoffrey A. Holdgate
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100156- (2024)
Fluorescent probe modulation assays are a widely used approach to monitor displacement or stabilisation of fluorescently labelled tool ligands by test compounds. These assays allow an optical read-out of probe-receptor binding and can be used to dete
Externí odkaz:
https://doaj.org/article/b96e0c80e0e648e5b46b6a6183f1051d
Autor:
Lanne, Alice, Bardelle, Catherine, Davies, Gareth, Turberville, Antonia, Semple, Hannah, Moore, Rachel, Holdgate, Geoffrey A.
Publikováno v:
In SLAS Discovery June 2024 29(4)
Autor:
Holdgate, Geoffrey A., Bardelle, Catherine, Berry, Sophia K., Lanne, Alice, Cuomo, Maria Emanuela
Publikováno v:
In SLAS Discovery March 2024 29(2)
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100136- (2024)
Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical properties that aim to stabilise the interaction between two proteins. Most often this approach is used to improve or induce an interaction
Externí odkaz:
https://doaj.org/article/211efed96a7d4fd58ebdc2e2a1299777