Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor

Autor: Valenciano, AL, Fernández-Murga, ML, Merino, EF, Holderman, NR, Butschek, GJ, Shaffer, Karl, Tyler, Peter, Cassera, MB

The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria parasite, chorismate is postulated to be a direct precursor in the synthesis of p-aminobenzoic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b121d11e321e0171abde327cd2697d1

Dissolved organic metabolite extraction from high-salt media.

Autor: Holderman NR; Department of Biochemistry and Molecular Biology and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA., Ferrer-González FX; Department of Marine Sciences, University of Georgia, Athens, Georgia, USA., Glushka J; Department of Biochemistry and Molecular Biology and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA., Moran MA; Department of Marine Sciences, University of Georgia, Athens, Georgia, USA., Edison AS; Department of Biochemistry and Molecular Biology and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA.

Publikováno v: NMR in biomedicine [NMR Biomed] 2023 Apr; Vol. 36 (4), pp. e4797. Date of Electronic Publication: 2022 Aug 10.

Resource partitioning of phytoplankton metabolites that support bacterial heterotrophy.

Autor: Ferrer-González FX; Department of Marine Sciences, University of Georgia, Athens, GA, 30602, USA., Widner B; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543, USA., Holderman NR; Department of Biochemistry and Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA., Glushka J; Department of Biochemistry and Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA., Edison AS; Department of Biochemistry and Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA., Kujawinski EB; Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543, USA., Moran MA; Department of Marine Sciences, University of Georgia, Athens, GA, 30602, USA. mmoran@uga.edu.

Publikováno v: The ISME journal [ISME J] 2021 Mar; Vol. 15 (3), pp. 762-773. Date of Electronic Publication: 2020 Oct 23.

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum.

Autor: Zimbres FM; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA., Valenciano AL; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA., Merino EF; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA., Florentin A; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA.; Department of Cellular Biology, University of Georgia, Athens, GA, 30602, USA., Holderman NR; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA., He G; School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA, 24061, USA., Gawarecka K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106, Warsaw, Poland., Skorupinska-Tudek K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106, Warsaw, Poland., Fernández-Murga ML; Laboratory of Experimental Pathology, Health Research Institute Hospital La Fe, 46026, Valencia, Spain., Swiezewska E; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106, Warsaw, Poland., Wang X; School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA, 24061, USA., Muralidharan V; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA.; Department of Cellular Biology, University of Georgia, Athens, GA, 30602, USA., Cassera MB; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA. maria.cassera@uga.edu.; Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA. maria.cassera@uga.edu.

Publikováno v: Scientific reports [Sci Rep] 2020 Aug 06; Vol. 10 (1), pp. 13264. Date of Electronic Publication: 2020 Aug 06.

Dysfunctional glycosynapses in schizophrenia: disease and regional specificity.

Autor: Wood PL; Metabolomics Unit, Dept. of Physiology and Pharmacology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, United States. Electronic address: paul.wood@lmunet.edu., Holderman NR; Metabolomics Unit, Dept. of Physiology and Pharmacology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, United States.

Publikováno v: Schizophrenia research [Schizophr Res] 2015 Aug; Vol. 166 (1-3), pp. 235-7. Date of Electronic Publication: 2015 May 23.