Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Hydrogel biomaterials that stiffen and soften on demand reveal that skeletal muscle stem cells harbor a mechanical memory.

Autor: Madl CM; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305.; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104., Wang YX; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305., Holbrook CA; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305., Su S; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305., Shi X; Department of Physiology, Perelman School of Medicine and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104., Byfield FJ; Department of Physiology, Perelman School of Medicine and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104., Wicki G; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305.; Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne CH-1015, Switzerland., Flaig IA; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305.; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Federale de Lausanne, Lausanne CH-1015, Switzerland., Blau HM; Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA 94305.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Aug 27; Vol. 121 (35), pp. e2406787121. Date of Electronic Publication: 2024 Aug 20.

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration.

Autor: Porpiglia E; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biomedicine, Aarhus University, Aarhus C 8000, Denmark. Electronic address: eporpiglia@biomed.au.dk., Mai T; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Kraft P; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Holbrook CA; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., de Morree A; Department of Biomedicine, Aarhus University, Aarhus C 8000, Denmark; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Gonzalez VD; Nolan Laboratory, Department of Pathology, Stanford University, Stanford, CA 94305, USA; Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA., Hilgendorf KI; Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Frésard L; Department of Pathology, Stanford University, Stanford, CA 94305, USA., Trejo A; Nolan Laboratory, Department of Pathology, Stanford University, Stanford, CA 94305, USA., Bhimaraju S; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Jackson PK; Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Stanford University School of Medicine, Stanford, CA 94305, USA., Fantl WJ; Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USA., Blau HM; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: hblau@stanford.edu.

Publikováno v: Cell stem cell [Cell Stem Cell] 2022 Dec 01; Vol. 29 (12), pp. 1653-1668.e8. Date of Electronic Publication: 2022 Nov 15.

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.

Autor: Palla AR; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Ravichandran M; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Wang YX; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Alexandrova L; Vincent Coates Foundation Mass Spectrometry Laboratory, Stanford University, Stanford, CA, USA., Yang AV; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Kraft P; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Holbrook CA; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Schürch CM; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA.; Nolan Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA., Ho ATV; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Blau HM; Blau Laboratory, Stanford School of Medicine, Stanford, CA 94305, USA. hblau@stanford.edu.; Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA 94305, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Jan 29; Vol. 371 (6528). Date of Electronic Publication: 2020 Dec 10.