Co-Morbidity Patterns Identified Using Latent Class Analysis of Medications Predict All-Cause Mortality Independent of Other Known Risk Factors: The COPDGene® Study

Autor: Li Y, Ragland M, Austin E, Young K, Pratte K, Hokanson JE, Beaty TH, Regan EA, Rennard SI, Wern C, Jacobs MR, Tal-Singer R, Make BJ, Kinney GL

Publikováno v: Clinical Epidemiology, Vol Volume 12, Pp 1171-1181 (2020)

Yisha Li,1 Margaret Ragland,1 Erin Austin,2 Kendra Young,1 Katherine Pratte,3 John E Hokanson,1 Terri H Beaty,4 Elizabeth A Regan,3 Stephen I Rennard,5 Christina Wern,6 Michael R Jacobs,7 Ruth Tal-Singer,8 Barry J Make,3 Gregory L Kinney1 On Behalf o

Externí odkaz: https://doaj.org/article/c54e625dac5c4edfa09d0f20f9c392f5

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Autor: Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, DM, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Team, 23Andme Research, Psychiatry, Hunt All-In, Choquet, H, Docherty, AR, Faul, JD, Foerster, JR, Fritsche, LG, Gabrielsen, ME, Gordon, SD, Haessler, J, Hottenga, J-J, Huang, H, Jang, S-K, Jansen, PR, Ling, Y, Mägi, R, Matoba, N, McMahon, G, Mulas, A, Orrù, V, Palviainen, T, Pandit, A, Reginsson, GW, Skogholt, AH, Smith, JA, Taylor, AE, Turman, C, Willemsen, G, Young, H, Young, KA, Zajac, GJM, Zhao, W, Zhou, W, Bjornsdottir, G, Boardman, JD, Boehnke, M, Boomsma, DI, Chen, C, Cucca, F, Davies, GE, Eaton, CB, Ehringer, MA, Esko, T, Fiorillo, E, Gillespie, NA, Gudbjartsson, DF, Haller, T, Harris, KM, Heath, AC, Hewitt, JK, Hickie, IB, Hokanson, JE, Hopfer, CJ, Hunter, DJ, Iacono, WG, Johnson, EO, Kamatani, Y, Kardia, SLR, Keller, MC, Kellis, M, Kooperberg, C, Kraft, P, Krauter, KS, Laakso, M, Lind, PA, Loukola, A, Lutz, SM, Madden, PAF, Martin, NG, McGue, M, McQueen, MB, Medland, SE, Metspalu, A, Mohlke, KL, Nielsen, JB, Okada, Y, Peters, U, Polderman, TJC, Posthuma, D, Reiner, AP, Rice, JP, Rimm, E, Rose, RJ, Runarsdottir, V, Stallings, MC, Stančáková, A, Stefansson, H, Thai, KK, Tindle, HA, Tyrfingsson, T, Wall, TL, Weir, DR, Weisner, C, Whitfield, JB, Winsvold, BS, Yin, J, Zuccolo, L, Bierut, LJ, Hveem, K, Lee, JJ, Munafò, MR, Saccone, NL, Willer, CJ, Cornelis, MC, David, SP, Hinds, DA, Jorgenson, E, Kaprio, J, Stitzel, JA, Stefansson, K, Thorgeirsson, TE, Abecasis, G, Liu, DJ, Vrieze, S

Publikováno v: Liu, M, Jiang, Y, Wedow, R, Li, Y, Brazel, D M, Chen, F, Datta, G, Davila-Velderrain, J, McGuire, D, Tian, C, Zhan, X, Agee, M, Alipanahi, B, Auton, A, Bell, R K, Bryc, K, Elson, S L, Fontanillas, P, Furlotte, N A, Hinds, D A, Hromatka, B S, Huber, K E, Kleinman, A, Litterman, N K, McIntyre, M H, Mountain, J L, Northover, C A M, Sathirapongsasuti, J F, Sazonova, O V, Shelton, J F, Shringarpure, S, Tian, C, Tung, J Y, Vacic, V, Wilson, C H, Pitts, S J, Mitchell, A, Skogholt, A H, Winsvold, B S, Sivertsen, B R, Stordal, E, Morken, G, Kallestad, H V, Heuch, I, Zwart, J-A, Fjukstad, K K, Pedersen, L M, Gabrielsen, M E, Jansen, P R, Posthuma, D, 23andMe Research team, Jorgenson, E, Stitzel, J A, Liu, D J & Vrieze, S 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
Nature Genetics
the 23 and Me Research Team 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
Nature Genetics, 51(2), 237-244. Nature Publishing Group
Liu, M, Hottenga, J J, Jansen, P R, Willemsen, G, Boomsma, D I, Davies, G E, Polderman, T J C, Posthuma, D, Vrieze, S, 23Andme Research Team & HUNT All-In Psychiatry 2019, ' Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use ', Nature Genetics, vol. 51, no. 2, pp. 237-244 . https://doi.org/10.1038/s41588-018-0307-5
PMC
Nature genetics
Nature genetics, 51(2), 237-244. Nature Publishing Group

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6,7,8,9,10,11. In sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f01e166190b1f57e8157a42854d232
https://research.vumc.nl/en/publications/d6127763-905e-44ae-88b1-ab80a1e7e269

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

Autor: Martinez, CH, Freeman, CM, Nelson, JD, Murray, S, Wang, X, Budoff, MJ, Dransfield, MT, Hokanson, JE, Kazerooni, EA, Kinney, GL, Regan, EA, Wells, JM, Martinez, FJ, Han, MK, Curtis, JL, Investigators, C

Publikováno v: Respiratory research, vol 18, iss 1
Martinez, CH; Freeman, CM; Nelson, JD; Murray, S; Wang, X; Budoff, MJ; et al.(2017). GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. RESPIRATORY RESEARCH, 18, 42. doi: 10.1186/s12931-017-0521-1. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1f24z25p

BackgroundGrowth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e692e538427ef3c70794f67b7b23ce6e
https://escholarship.org/uc/item/1f24z25p

Clinical and radiologic disease in smokers with normal spirometry

Autor: Regan, EA, Lynch, DA, Curran-Everett, D, Curtis, JL, Austin, JHM, Grenier, PA, Kauczor, HU, Bailey, WC, De Meo, DL, Casaburi, RH, Friedman, P, Van Beek, EJR, Hokanson, JE, Bowler, RP, Beaty, TH, Washko, GR, Han, MK, Kim, V, Kim, SS, Yagihashi, K, Washington, L, McEvoy, CE, Tanner, C, Mannino, DM, Make, BJ, Silverman, EK, Crapo, JD, Martinez, C, Pernicano, PG, Hanania, N, Alapat, P, Bandi, V, Atik, M, Boriek, A, Guntupalli, K, Guy, E, Parulekar, A, Nachiappan, A, Hersh, C, Jacobson, F, Barr, RG, Thomashow, B, D'Souza, B, Pearson, GDN, Rozenshtein, A, MacIntyre, N, McAdams, HP, Tashjian, J, Wise, R, Hansel, N, Brown, R, Horton, K, Putcha, N, Adami, A, Porszasz, J, Fischer, H, Budoff, M, Cannon, D, Rossiter, H, Sharafkhaneh, A, Lan, C, Wendt, C, Bell, B, Foreman, M, Westney, G, Berkowitz, E, Rosiello, R, Pace, D, Criner, G, Ciccolella, D, Cordova, F, Dass, C, D'Alonzo, R, Desai, P, Jacobs, M, Kelsen, S, Mamary, AJ, Marchetti, N, Satti, A, Shenoy, K, Steiner, RM, Swift, A, Swift, I, Vega-Sanchez, G, Dransfield, M, Wells, JM, Bhatt, S, Nath, H, Ramsdell, J, Soler, X, Yen, A, Cornellas, A, Newell, J, Thompson, B, Kazerooni, E, Martinez, F, Billings, J, Allen, T

Publikováno v: Regan, EA; Lynch, DA; Curran-Everett, D; Curtis, JL; Austin, JHM; Grenier, PA; et al.(2015). Clinical and radiologic disease in smokers with normal spirometry. JAMA Internal Medicine, 175(9), 1539-1549. doi: 10.1001/jamainternmed.2015.2735. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1h82f9z8

Copyright 2015 American Medical Association. All rights reserved. IMPORTANCE: Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2629b6ee5e60f54565ffe30027b3baaf
http://www.escholarship.org/uc/item/1h82f9z8

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