Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hok Sau Kwong"'
Autor:
Kamel El Omari, Ramona Duman, Vitaliy Mykhaylyk, Christian M. Orr, Merlyn Latimer-Smith, Graeme Winter, Vinay Grama, Feng Qu, Kiran Bountra, Hok Sau Kwong, Maria Romano, Rosana I. Reis, Lutz Vogeley, Luca Vecchia, C. David Owen, Sina Wittmann, Max Renner, Miki Senda, Naohiro Matsugaki, Yoshiaki Kawano, Thomas A. Bowden, Isabel Moraes, Jonathan M. Grimes, Erika J. Mancini, Martin A. Walsh, Cristiane R. Guzzo, Raymond J. Owens, E. Yvonne Jones, David G. Brown, Dave I. Stuart, Konstantinos Beis, Armin Wagner
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by mea
Externí odkaz:
https://doaj.org/article/8684a241320c432f8b25757e0cf6d695
Autor:
Jakub Gruszczyk, Loïc Grandvuillemin, Josephine Lai-Kee-Him, Matteo Paloni, Christos G. Savva, Pierre Germain, Marina Grimaldi, Abdelhay Boulahtouf, Hok-Sau Kwong, Julien Bous, Aurélie Ancelin, Cherine Bechara, Alessandro Barducci, Patrick Balaguer, William Bourguet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Aryl hydrocarbon receptor (AHR) is a sensor of the chemical environment including pollutants, diet components and metabolites. Here, authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into liga
Externí odkaz:
https://doaj.org/article/ada9a76084db488fb5e5963b48693d01
Autor:
Sophia David, Joshua L C Wong, Julia Sanchez-Garrido, Hok-Sau Kwong, Wen Wen Low, Fabio Morecchiato, Tommaso Giani, Gian Maria Rossolini, Stephen J Brett, Abigail Clements, Konstantinos Beis, David M Aanensen, Gad Frankel
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010334 (2022)
Mutations in outer membrane porins act in synergy with carbapenemase enzymes to increase carbapenem resistance in the important nosocomial pathogen, Klebsiella pneumoniae (KP). A key example is a di-amino acid insertion, Glycine-Aspartate (GD), in th
Externí odkaz:
https://doaj.org/article/2aaddeed4753482ca9867a810134d51d
Autor:
Kamel El Omari, Nada Mohamad, Kiran Bountra, Ramona Duman, Maria Romano, Katja Schlegel, Hok-Sau Kwong, Vitaliy Mykhaylyk, Claus Olesen, Jesper Vuust Moller, Maike Bublitz, Konstantinos Beis, Armin Wagner
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1092-1101 (2020)
The structure determination of soluble and membrane proteins can be hindered by the crystallographic phase problem, especially in the absence of a suitable homologous structure. Experimental phasing is the method of choice for novel structures; howev
Externí odkaz:
https://doaj.org/article/97406e4f17cc4e1cac866e06b368fa63
Autor:
Joshua L. C. Wong, Maria Romano, Louise E. Kerry, Hok-Sau Kwong, Wen-Wen Low, Stephen J. Brett, Abigail Clements, Konstantinos Beis, Gad Frankel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Abstract Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36. However, the mechanism underpinning OmpK36-media
Externí odkaz:
https://doaj.org/article/048fe9334b3d4543a8b1643b71a6d1c0
Autor:
Joshua L. C. Wong, Maria Romano, Louise E. Kerry, Hok-Sau Kwong, Wen-Wen Low, Stephen J. Brett, Abigail Clements, Konstantinos Beis, Gad Frankel
Publikováno v:
Nature Communications. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::977d3426a29683ff0ae740b445f5573d
https://doi.org/10.1038/s41467-023-37549-y
https://doi.org/10.1038/s41467-023-37549-y
Autor:
Wen Wen Low, Joshua L. C. Wong, Leticia C. Beltran, Chloe Seddon, Sophia David, Hok-Sau Kwong, Tatiana Bizeau, Fengbin Wang, Alejandro Peña, Tiago R. D. Costa, Bach Pham, Min Chen, Edward H. Egelman, Konstantinos Beis, Gad Frankel
Publikováno v:
Nature microbiology. 7(7)
Bacterial conjugation mediates contact-dependent transfer of DNA from donor to recipient bacteria, thus facilitating the spread of virulence and resistance plasmids. Here we describe how variants of the plasmid-encoded donor outer membrane (OM) prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b29bc3d57afc759273237c1a9653ca
https://pubmed.ncbi.nlm.nih.gov/35697796
https://pubmed.ncbi.nlm.nih.gov/35697796
Autor:
Hok-Sau Kwong, Maike Bublitz, Claus Olesen, Vitaliy Mykhaylyk, Armin Wagner, Jesper V. Møller, Konstantinos Beis, Nada Mohamad, R. Duman, Kiran Bountra, Katja Schlegel, Maria Romano, Kamel El Omari
Publikováno v:
El Omari, K, Mohamad, N, Bountra, K, Duman, R, Romano, M, Schlegel, K, Kwong, H S, Mykhaylyk, V, Olesen, C, Moller, J V, Bublitz, M, Beis, K & Wagner, A 2020, ' Experimental phasing with vanadium and application to nucleotide-binding membrane proteins ', IUCrJ, vol. 7, pp. 1092-1101 . https://doi.org/10.1107/S2052252520012312
IUCrJ
IUCrJ, Vol 7, Iss 6, Pp 1092-1101 (2020)
IUCrJ
IUCrJ, Vol 7, Iss 6, Pp 1092-1101 (2020)
Crystal structure determination of membrane proteins can be challenging. Here, the use of vanadium phasing as an alternative experimental phasing method is described.
The structure determination of soluble and membrane proteins can be hindered b
The structure determination of soluble and membrane proteins can be hindered b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28328d9c9902e5aac0e2af9ca97c9b7
https://pure.au.dk/portal/da/publications/experimental-phasing-with-vanadium-and-application-to-nucleotidebinding-membrane-proteins(dcfd4d87-3c0b-48c7-bd03-b434a797e37e).html
https://pure.au.dk/portal/da/publications/experimental-phasing-with-vanadium-and-application-to-nucleotidebinding-membrane-proteins(dcfd4d87-3c0b-48c7-bd03-b434a797e37e).html
Autor:
Hok-Sau Kwong, Louise Kerry, Konstantinos Beis, Joshua L.C. Wong, Gad Frankel, Wen-Wen Low, Maria Romano, Stephen J. Brett, Abigail Clements
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36. However, the mechanism underpinning OmpK36-mediated resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce60a28e099f9e77855de9c57456246
https://pubmed.ncbi.nlm.nih.gov/31477712
https://pubmed.ncbi.nlm.nih.gov/31477712
Autor:
Thomas Acton, Sam Festenstein, Charikleia Black, John J. Barker, Richard B. Hitchman, Hok Sau Kwong
Publikováno v:
Methods in Molecular Biology ISBN: 9781493968855
We have developed a standardized and efficient workflow for high-throughput (HT) protein expression in E. coli and parallel purification which can be tailored to the downstream application of the target proteins. It includes a one-step purification f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5580a5e6a150b63de3b2516d5ae87780
https://doi.org/10.1007/978-1-4939-6887-9_24
https://doi.org/10.1007/978-1-4939-6887-9_24