Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hojoong Kwak"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Enhancer RNAs (eRNAs) are non-coding RNAs produced by transcriptional enhancers that are highly correlated with their activity. Using a capped nascent RNA sequencing (PRO-cap) dataset in human lymphoblastoid cell lines across 67 individuals,
Externí odkaz:
https://doaj.org/article/478f3b1ccbc741fab1435b7a53e92292
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing
Externí odkaz:
https://doaj.org/article/717671be17124b458fe0fc9bad99be2f
Autor:
Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108077- (2020)
Summary: DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the transcriptome response of cultured colon cancer cell lines to 5-fluorour
Externí odkaz:
https://doaj.org/article/facdc4df9ebe4a08abfce4382f5413e6
Autor:
Yue Zhao, Qi Liu, Pankaj Acharya, Kristy R. Stengel, Quanhu Sheng, Xiaofan Zhou, Hojoong Kwak, Melissa A. Fischer, James E. Bradner, Stephen A. Strickland, Sanjay R. Mohan, Michael R. Savona, Bryan J. Venters, Ming-Ming Zhou, John T. Lis, Scott W. Hiebert
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 2003-2016 (2016)
Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases acros
Externí odkaz:
https://doaj.org/article/cf9b89b3be554977ab7d018484f46c0c
Autor:
Yu Mi Woo, Yeonui Kwak, Sim Namkoong, Katla Kristjánsdóttir, Seung Ha Lee, Jun Hee Lee, Hojoong Kwak
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3630-3641.e7 (2018)
Summary: Post-transcriptional RNA processing is a core mechanism of gene expression control in cell stress response. The poly(A) tail influences mRNA translation and stability, but it is unclear whether there are global roles of poly(A)-tail lengths
Externí odkaz:
https://doaj.org/article/150a6a60b4c24d6f9b7874bea1aeb25b
Autor:
Ian C. Welsh, Hojoong Kwak, Frances L. Chen, Melissa Werner, Lindsay S. Shopland, Charles G. Danko, John T. Lis, Min Zhang, James F. Martin, Natasza A. Kurpios
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 337-349 (2015)
Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the dorsal mesentery (DM), whose asymmetric cell behavior directs gut looping. Despite the importance of organ laterality, chromatin-level regulation of Pitx
Externí odkaz:
https://doaj.org/article/307d6acf42cb4ec39f3c4b96c11eb498
Autor:
Isabel X. Wang, Leighton J. Core, Hojoong Kwak, Lauren Brady, Alan Bruzel, Lee McDaniel, Allison L. Richards, Ming Wu, Christopher Grunseich, John T. Lis, Vivian G. Cheung
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 906-915 (2014)
RNA sequences are expected to be identical to their corresponding DNA sequences. Here, we found all 12 types of RNA-DNA sequence differences (RDDs) in nascent RNA. Our results show that RDDs begin to occur in RNA chains ∼55 nt from the RNA polymera
Externí odkaz:
https://doaj.org/article/5f2aebfb28ce422f95afdc0f229f309e
Autor:
Leighton J. Core, Joshua J. Waterfall, Daniel A. Gilchrist, David C. Fargo, Hojoong Kwak, Karen Adelman, John T. Lis
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 1025-1035 (2012)
Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II) accumulates to high densities on many promoters at a rate-limited step in transcription. However, the status of this Pol II remains an area of debate. Here, we compare
Externí odkaz:
https://doaj.org/article/8cc01b03365344349b16149a8bdddb72
Publikováno v:
eLife, Vol 3 (2014)
Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation. To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either initiation or promoter-proximal pause escape with Triptolide or Flav
Externí odkaz:
https://doaj.org/article/b58e379d2f8c4a7b96ea73bba0e51b7b
Autor:
P R V Satyaki, Tawny N Cuykendall, Kevin H-C Wei, Nicholas J Brideau, Hojoong Kwak, S Aruna, Patrick M Ferree, Shuqing Ji, Daniel A Barbash
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004240 (2014)
Hybrid incompatibilities (HIs) cause reproductive isolation between species and thus contribute to speciation. Several HI genes encode adaptively evolving proteins that localize to or interact with heterochromatin, suggesting that HIs may result from
Externí odkaz:
https://doaj.org/article/c55bbd8214cb43cba6eb85535998fd6f