Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hojong, Yoon"'
Autor:
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106601- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-
Externí odkaz:
https://doaj.org/article/cb16503b59c14a149316faaa454be17e
Publikováno v:
Journal of Clinical Investigation. 1/2/2024, Vol. 134 Issue 1, p1-10. 10p.
Autor:
Chiman Song, SeongShick Ryu, Nam Doo Kim, Nam Hoon Kwon, Taebo Sim, Injae Shin, Eunhye Jeon, Ji Won Lee, Youngji Moon, Young Hoon Kim, Hojong Yoon, Sunghoon Kim, Hwan Geun Choi, Hanna Cho
Publikováno v:
Journal of Medicinal Chemistry. 64:11934-11957
Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-d]pyrimidine derivatives. An intensive structure-activity relationship (SAR) stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5deef0a2082593f2759a2669c42e311
https://doi.org/10.1021/acs.jmedchem.1c00459
https://doi.org/10.1021/acs.jmedchem.1c00459
Autor:
Yen-Der Li, Michelle W. Ma, Muhammad Murtaza Hassan, Kedar Puvar, Mingxing Teng, Brittany Sandoval, Ryan Lumpkin, Scott B. Ficarro, Michelle Y. Wang, Shawn Xu, Brian J. Groendyke, Logan H. Sigua, Isidoro Tavares, Charles Zou, Jonathan M. Tsai, Paul M. Park, Hojong Yoon, Radosław P. Nowak, Jarrod A. Marto, Jun Qi, Katherine A. Donovan, Mikołaj Słabicki, Nathanael S. Gray, Eric S. Fischer, Benjamin L. Ebert
Publikováno v:
Cancer Research. 83:3424-3424
Molecular glue degraders have emerged as a powerful class of small-molecule therapeutics, as demonstrated by the clinical successes of thalidomide analogs in the treatment of hematological malignancies. These small molecules act by recruiting ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a5b6eba7ac746545c7a80669b65a86
https://doi.org/10.1158/1538-7445.am2023-3424
https://doi.org/10.1158/1538-7445.am2023-3424
Autor:
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla Heavican-Foral, Huiyun Liu, Geoffrey Nelson, Lu Yang, Renee Chen, Katherine Donovan, Marcus Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit Nirmal, Salvia Jain, Catharine Leahy, Kristen Jones, Kristen Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing Chan Chan, Shannan Ho Sui Ho Sui, Samuel Ng, Andrew Feldman, Steven M. Horwitz, Mathew Meyerson, Karen Adelman, Eric Fischer, Chun-Wei Chen, David Weinstock, Myles Brown
Publikováno v:
Cancer Research. 83:5755-5755
Recurrent chromosomal rearrangements are a hallmark of hematologic malignancies and play critical roles in pathogenesis. The TP53 analog TP63 is rearranged in 5-10% of diverse subtypes of both aggressive T- and B-cell lymphomas. Patients with TP63-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ac091127ae2e99d318812ef2ddcf036
https://doi.org/10.1158/1538-7445.am2023-5755
https://doi.org/10.1158/1538-7445.am2023-5755
Autor:
Shourya S. Roy Burman, Rohan Sharma, Moritz Hunkeler, Peter Miller, Benjamin L. Ebert, Stefan Fröhling, Andrew A Guirguis, Claudia Scholl, Lena Nitsch, Priya Chudasama, Radosław P. Nowak, Hojong Yoon, Katherine A. Donovan, Cristina Di Genua, Charles Zou, Adam S. Sperling, Jessica A. Gasser, Eric S. Fischer, Jonathan M. Tsai, Mikolaj Slabicki, Jonas Koeppel
Publikováno v:
Nature
Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of transcription facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ed3b388c12a2bea67b34032dc473b
https://doi.org/10.1038/s41586-020-2925-1
https://doi.org/10.1038/s41586-020-2925-1
Publikováno v:
Nat Struct Mol Biol
Controlled perturbation of protein activity is essential to study protein function in cells and living organisms. Small molecules that hijack the cellular protein ubiquitination machinery to selectively degrade proteins of interest, so-called degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab94bbf710a6045afb65417591d36ae0
https://doi.org/10.1038/s41594-020-0438-0
https://doi.org/10.1038/s41594-020-0438-0
Autor:
Hyunyoung Moon, Hojong Yoon, Changjin Lim, Jaebong Jang, Jong-Jae Yi, Jae Kyun Lee, Jeeyeon Lee, Younghwa Na, Woo Sung Son, Seok-Ho Kim, Young-Ger Suh
Publikováno v:
Molecules, Vol 23, Iss 9, p 2351 (2018)
The versatile synthesis of (−)-6-desmethyl-fluvirucinine A1 was accomplished at a 24% overall yield through a thirteen-step process from a known vinylpiperidine. The key part involved the elaboration of the distal stereocenters and a macrolactam sk
Externí odkaz:
https://doaj.org/article/7d971af0f21f4db7b6006981491f73b7
Autor:
Guangyan Du, Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
Publikováno v:
Cell Chemical Biology. 29:1470-1481.e31
Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into the proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major bottleneck in the TPD field is the lack of accessible E3 ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd18917650df053c5eafa56606f1849a
https://doi.org/10.1016/j.chembiol.2022.08.003
https://doi.org/10.1016/j.chembiol.2022.08.003
Autor:
Hanna, Cho, Injae, Shin, Hojong, Yoon, Eunhye, Jeon, Jiwon, Lee, Younghoon, Kim, SeongShick, Ryu, Chiman, Song, Nam Hoon, Kwon, Youngji, Moon, Sunghoon, Kim, Nam Doo, Kim, Hwan Geun, Choi, Taebo, Sim
Publikováno v:
Journal of medicinal chemistry. 64(16)
Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d6d1b1ab771cdc85d913f2784350fce
https://pubmed.ncbi.nlm.nih.gov/34324343
https://pubmed.ncbi.nlm.nih.gov/34324343