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Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.

Autor: de Andrade P; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil., Mantoani SP; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil., Gonçalves Nunes PS; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil., Magadán CR; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain., Pérez C; Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, Madrid 28006, Spain., Xavier DJ; Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil., Hojo ETS; Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, 14040-900 Ribeirão Preto, SP, Brazil., Campillo NE; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain., Martínez A; Centro de Investigaciones Biologicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid 28040, Spain., Carvalho I; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil. Electronic address: carronal@usp.br.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Mar 15; Vol. 27 (6), pp. 931-943. Date of Electronic Publication: 2018 Dec 23.