A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population.

Autor: Hoi Y Tong, Cristina Lucía Dávila-Fajardo, Alberto M Borobia, Luis Javier Martínez-González, Rubin Lubomirov, Laura María Perea León, María J Blanco Bañares, Xando Díaz-Villamarín, Carmen Fernández-Capitán, José Cabeza Barrera, Antonio J Carcas, PGX-ACE Investigators Group

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0150456 (2016)

There is a strong association between genetic polymorphisms and the acenocoumarol dosage requirements. Genotyping the polymorphisms involved in the pharmacokinetics and pharmacodynamics of acenocoumarol before starting anticoagulant therapy would res

Externí odkaz: https://doaj.org/article/6bba3485df7f4c758ff1011471dfd5ff

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

Autor: Rajagopal Krishnamoorthy, Yusuke Nakamura, Alice Giontella, Elisa Danese, Munir Pirmohamed, Hoi Y. Tong, Angela Tagetti, Marie-Anne Loriot, Pietro Minuz, Anke H. Maitland-van der Zee, Sheng-Lan Tan, Jim K Burmester, Richard B. Kim, Jamila Alessandra Perini, Ming Ta Michael Lee, Nita A. Limdi, Min Huang, Mohamed H. Shahin, Guilherme Suarez-Kurtz, Vanessa Roldán, Carlos Isaza, Hersh Sagreiya, Hye Sun Gwak, Vijay Kumar Kutala, Han-Jing Cen, Russ B. Altman, Antonio J. Carcas, Kunihiko Itoh, Vaiva Lesauskaite, Richard L. Berg, Cristina Mazzaccara, Kyung Eun Lee, Mariana R. Botton, Jieying Eunice Zhang, Anthonius de Boer, Yumao Zhang, Inna Y. Gong, Marianne K. Kringen, Paola Borgiani, Taimour Y. Langaee, Monica Taljaard, Vacis Tatarunas, Panos Deloukas, Chrisly Dillon, Alberto M. Borobia, Michael D. Caldwell, Katarzyna Drozda, Larisa H. Cavallari, Julie A. Johnson, Stephane Bourgeois, Lucia Sacchetti, Saurabh Singh Rathore, Stuart A. Scott, Martina Montagnana, Li-Zi Zhao, Charles A. Rivers, Mahmut Ozer, Taisei Mushiroda, Cristina Lucía Dávila-Fajardo, Andras Paldi, Marisa Cañadas-Garre, Rocío González-Conejero, Talitha I. Verhoef, Sherief Khalifa, Ivet Suriapranata, Carlo Federico Zambon, Balraj Mittal, Sara Raimondi, Ece Genc, Virginie Siguret, Andrea H. Ramirez, Cinzia Ciccacci, Keita Hirai, Enrique Jiménez-Varo, Hong-Hao Zhou, Anil Pathare, Steven A. Lubitz, Josh C. Denny, Aditi Shendre, Leonardo Beltrán, Kari Bente Foss Haug, Cristiano Fava, Vittorio Pengo

Publikováno v: Clin Pharmacol Ther
Clinical Pharmacology and Therapeutics, 105(6), 1477. Nature Publishing Group
Danese, E, Sara, R, Montagnana, M, Tagetti, A, Langaee, T, Borgiani, P, Ciccacci, C, Carcas, A J, Borobia, A M, Tong, H Y, Davila Fajardo, C, Rodrigues Botton, M, Bourgeois, S, Deloukas, P, Caldwell, M D, Burmester, J K, Berg, R L, Cavallari, L H, Drozda, K, Huang, M, Zhao, L-Z, Cen, H-J, Gonzalez-Conejero, R, Roldan, V, Nakamura, Y, Mushiroda, T, Gong, I Y, Kim, R B, Hirai, K, Itoh, K, Isaza, C, Beltran, L, Jimenez-Varo, E, Cañadas-Garre, M, Giontella, A, Kristiansen Kringen, M, Bente Foss Haug, K, Gwak, H S, Lee, K E, Minuz, P, Lee, M T M, Lubitz, S A, Scott, S, Mazzaccara, C, Sacchetti, L, Genç, E, Özer, M, Pathare, A, Krishnamoorthy, R, Paldi, A, Siguret, V, Loriot, M-A, Kumar Kutala, V, Suarez-Kurtz, G, Perini, J, Denny, J C, Ramirez, A H, Mittal, B, Singh Rathore, S, Sagreiya, H, Altman, R, Shahin, M H A, Khalifa, S I, Lindi, N A, Rivers, C, Shendre, A, Dillon, C, Suriapranata, I M, Zhou, H-H, Tan, S-L, Tatarunas, V, Lesauskaite, V, Zhang, Y, Maitland-van der Zee, A H, Verhoef, T I, de Boer, A, Taljaard, M, Zambon, C F, Pengo, V, zhang, J E, Pirmohamed, M, Johnson, J A & Fava, C 2018, ' The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose. A single patient data meta-analysis in more than 15,000 individuals ', Clinical Pharmacology and Therapeutics . https://doi.org/10.1002/cpt.1323
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 2019, 105 (6), pp.1477-1491. ⟨10.1002/cpt.1323⟩
Clinical pharmacology and therapeutics, 105(6), 1477-1491. Wiley-Blackwell
Clinical pharmacology and therapeutics
Paediatrics Publications

The CYP4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at individual patients' level to capture the possible effect of ethnicity, gene-gene interaction or other drugs on the association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f48f76671021f7043e3ac2ca8c9e251
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061927761&origin=inward

Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years

Autor: Pedro Arias, Elena Ramírez, Pablo Lapunzina, Mario Muñoz, Irene García García, Jesús Frías, Antonio J. Carcas, Jair Tenorio, Hoi Y. Tong, Gema Gordo, Irene Dapía, Alberto M. Borobia, Rafael Hernandez

Publikováno v: Clinical and Translational Science. 11:189-199

In 2014, we established a pharmacogenetics unit with the intention of facilitating the integration of pharmacogenetic testing into clinical practice. This unit was centered around two main ideas: i) individualization of clinical recommendations, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7ec7eed7c397fddd3c5fc8d7d3ae916
https://doi.org/10.1111/cts.12526

Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital

Autor: Elena Ramírez, Pedro Herranz, Teresa Bellón, Alberto M. Borobia, Ana Fiandor, Jesús Frías, Mario Muñoz, Antonio J. Carcas, Jessica González-Ramos, Hoi Y. Tong, Elena Trigo, Nicolás Medrano-Casique, Rosario Cabañas

Publikováno v: British Journal of Clinical Pharmacology. 83:400-415

Aim We conducted a prospective evaluation of all eosinophilic drug reactions (EDRs) through the Prospective Pharmacovigilance Program from Laboratory Signals at Hospital to find out the incidence and distribution of these entities in our hospital, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec5dc50ade20438d1bc156ac3cdc0d5b
https://doi.org/10.1111/bcp.13096

Correction to: Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction

Autor: Paolo Guerra, J. C. Martínez-Ávila, Jesús Frías, Irene Dapía, A. García Bartolomé, Irene Salvo García, Alberto M. Borobia, A. J. Carcás Sansuan, Lucía Díaz, Hoi Y. Tong

Publikováno v: Metabolomics. 14

The original version of this article contains a mistake.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c250fedd3f1878a3dbf3bc534057879
https://doi.org/10.1007/s11306-018-1378-0