Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.

Autor: Hu X; Sana Biotechnology, Inc., South San Francisco, CA, USA., White K; Sana Biotechnology, Inc., South San Francisco, CA, USA., Olroyd AG; Sana Biotechnology, Inc., South San Francisco, CA, USA., DeJesus R; Sana Biotechnology, Inc., South San Francisco, CA, USA., Dominguez AA; Sana Biotechnology, Inc., South San Francisco, CA, USA., Dowdle WE; Sana Biotechnology, Inc., South San Francisco, CA, USA., Friera AM; Sana Biotechnology, Inc., South San Francisco, CA, USA., Young C; Sana Biotechnology, Inc., South San Francisco, CA, USA., Wells F; Sana Biotechnology, Inc., South San Francisco, CA, USA., Chu EY; Sana Biotechnology, Inc., South San Francisco, CA, USA., Ito CE; Sana Biotechnology, Inc., South San Francisco, CA, USA., Krishnapura H; Sana Biotechnology, Inc., South San Francisco, CA, USA., Jain S; Sana Biotechnology, Inc., South San Francisco, CA, USA., Ankala R; Sana Biotechnology, Inc., South San Francisco, CA, USA., McGill TJ; Sana Biotechnology, Inc., South San Francisco, CA, USA., Lin A; Sana Biotechnology, Inc., South San Francisco, CA, USA., Egenberger K; Sana Biotechnology, Inc., South San Francisco, CA, USA., Gagnon A; Sana Biotechnology, Inc., South San Francisco, CA, USA., Michael Rukstalis J; Sana Biotechnology, Inc., South San Francisco, CA, USA., Hogrebe NJ; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA., Gattis C; Sana Biotechnology, Inc., South San Francisco, CA, USA., Basco R; Sana Biotechnology, Inc., South San Francisco, CA, USA., Millman JR; Sana Biotechnology, Inc., South San Francisco, CA, USA., Kievit P; Division of Cardiometabolic Health, Oregon National Primate Research Center, Beaverton, OR, USA., Davis MM; Howard Hughes Medical Institute, Institute for Immunity, Transplantation and Infection, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Lanier LL; Department of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, USA., Connolly AJ; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., Deuse T; Transplant and Stem Cell Immunobiology (TSI) Lab, Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, San Francisco, CA, USA., Schrepfer S; Sana Biotechnology, Inc., South San Francisco, CA, USA. sonja.schrepfer@sana.com.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Mar; Vol. 42 (3), pp. 413-423. Date of Electronic Publication: 2023 May 08.

Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification.

Autor: Augsornworawat P; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Hogrebe NJ; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Ishahak M; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Schmidt MD; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Marquez E; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Maestas MM; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Veronese-Paniagua DA; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Gale SE; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Miller JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Velazco-Cruz L; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA., Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, MSC 8127-057-08, St. Louis, MO, USA. jmillman@wustl.edu.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. jmillman@wustl.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2023 Jun; Vol. 25 (6), pp. 904-916. Date of Electronic Publication: 2023 May 15.

Generation of insulin-producing pancreatic β cells from multiple human stem cell lines.

Autor: Hogrebe NJ; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA., Maxwell KG; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Augsornworawat P; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA. jmillman@wustl.edu.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA. jmillman@wustl.edu.

Publikováno v: Nature protocols [Nat Protoc] 2021 Sep; Vol. 16 (9), pp. 4109-4143. Date of Electronic Publication: 2021 Aug 04.

Gene-edited human stem cell-derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice.

Autor: Maxwell KG; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Augsornworawat P; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Velazco-Cruz L; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Kim MH; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Asada R; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Hogrebe NJ; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Morikawa S; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Urano F; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. jmillman@wustl.edu urano@wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Millman JR; Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. jmillman@wustl.edu urano@wustl.edu.; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Apr 22; Vol. 12 (540).

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells.

Autor: Velazco-Cruz L; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Song J; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Maxwell KG; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Goedegebuure MM; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Augsornworawat P; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA., Hogrebe NJ; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA., Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO 63130, USA. Electronic address: jmillman@wustl.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2019 Feb 12; Vol. 12 (2), pp. 351-365. Date of Electronic Publication: 2019 Jan 17.