The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

Autor: Abdelnabi, R, Foo, CS, Jochmans, D, Vangeel, L, De Jonghe, S, Augustijns, P, Mols, R, Weynand, B, Wattanakul, T, Hoglund, RM, Tarning, J, Mowbray, CE, Sjö, P, Escudié, F, Scandale, I, Chatelain, E, Neyts, J

Publikováno v: Nature communications. 13(1)

There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df02a56b06fd0f38fc6337ca6b38f57c
https://pubmed.ncbi.nlm.nih.gov/35169114

Population pharmacokinetic properties of Piperaquine in Falciparum Malaria: an individual participant data-level meta-analysis

Autor: Hoglund, RM, Workman, L, Edstein, MD, Thanh, NX, Quang, NN, Zongo, I, Ouedraogo, JB, Borrmann, S, Mwai, L, Nsanzabana, C, Price, RN, Dahal, P, Sambol, NC, Parikh, S, Nosten, F, Ashley, EA, Phyo, AA, Lwin, KM, McGready, R, Day, N, Guerin, PJ, White, NJ, Barnes, KI, Tarning, J

Publikováno v: PLoS Medicine.

Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated P.falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::bf2252a4dbeae8095f24b664a85e47ab
http://ora.ox.ac.uk/objects/uuid:

Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections.

Autor: Ding J; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Hoglund RM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Tagbor H; University of Health and Allied Sciences, Ho, Ghana., Tinto H; Clinical Trial Unit Nanoro, Nanoro, Burkina Faso., Valéa I; Clinical Trial Unit Nanoro, Nanoro, Burkina Faso., Mwapasa V; Department of Community and Environmental Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Kalilani-Phiri L; Department of Community and Environmental Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Van Geertruyden JP; Global Health Institute, University of Antwerp, Antwerp, Belgium., Nambozi M; The Tropical Diseases Research Center, Ndola, Zambia., Mulenga M; The Tropical Diseases Research Center, Ndola, Zambia., Hachizovu S; The Tropical Diseases Research Center, Ndola, Zambia., Ravinetto R; Public Health Department, Institute of Tropical Medicine, Antwerp, Belgium.; School of Public Health, University of the Western Cape, Cape Town, South Africa., D'Alessandro U; MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia., Tarning J; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; The WorldWide Antimalarial Resistance Network, Oxford, UK.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Nov; Vol. 13 (11), pp. 1893-1903. Date of Electronic Publication: 2024 Sep 03.

A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults.

Autor: Hanboonkunupakarn B; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Mukaka M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Jittamala P; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Poovorawan K; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Pongsuwan P; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Stockdale L; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Provstgaard-Morys S; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Chotivanich K; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Tarning J; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Hoglund RM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Chimjinda N; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Ewer K; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.; GSK, GSK Vaccines Institute for Global Health, Siena, Italy., Ramos-Lopez F; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, UK., Day NPJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Dondorp AM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Hill AV; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., White NJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. lorenz@tropmedres.ac.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. lorenz@tropmedres.ac., Pukrittayakamee S; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; The Royal Society of Thailand, Dusit, Bangkok, Thailand.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Jul 06; Vol. 9 (1), pp. 124. Date of Electronic Publication: 2024 Jul 06.

Medication adherence framework: A population-based pharmacokinetic approach and its application in antimalarial treatment assessments.

Autor: Ding J; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; The WorldWide Antimalarial Resistance Network, Oxford, UK., Hoglund RM; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Tarning J; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; The WorldWide Antimalarial Resistance Network, Oxford, UK.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 May; Vol. 13 (5), pp. 795-811. Date of Electronic Publication: 2024 Mar 25.