Ophthalmate is a new regulator of motor functions via CaSR: implications for movement disorders.

Autor: Alhassen S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA., Hogenkamp D; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA.; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA., Nguyen HA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA., Al Masri S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA., Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California Irvine, Irvine, CA 92697, USA., Civelli O; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA.; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA., Alachkar A; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California Irvine, Irvine, CA 92697, USA.; Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California Irvine, Irvine, CA 92697, USA.; UC Irvine Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA 92697, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Oct 03; Vol. 147 (10), pp. 3379-3394.

Polymodal K ⁺ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.

Autor: Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Yoshimura RF; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Yeromin AV; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Hogenkamp D; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., van der Horst J; Department of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Zavala A; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Chinedu S; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Arena G; Redwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA., Lasky E; Redwood Creek Vegetation Team, National Park Service, Sausalito, CA, USA., Fisher M; Philip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA., Tracy CR; Philip L. Boyd Deep Canyon Desert Research Center, University of California Natural Reserve System, Indian Wells, CA, USA., Othy S; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Jepps TA; Department of Biomedical Sciences, Vascular Biology Group, Panum Institute, University of Copenhagen, Copenhagen, Denmark., Cahalan MD; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA., Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA, USA. abbottg@hs.uci.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Aug 28; Vol. 7 (1), pp. 1059. Date of Electronic Publication: 2024 Aug 28.

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Discovery of a potent, Kv7.3-selective potassium channel opener from a Polynesian traditional botanical anticonvulsant.

Autor: Abbott, Geoffrey W.¹ (AUTHOR) abbottg@hs.uci.edu, Manville, Rían W.¹ (AUTHOR)

Publikováno v: Communications Chemistry. 10/10/2024, Vol. 7 Issue 1, p1-15. 15p.

Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury.

Autor: Titus DJ; Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America., Johnstone T; Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, California, United States of America., Johnson NH; Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America., London SH; Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America., Chapalamadugu M; Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America., Hogenkamp D; Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, California, United States of America., Gee KW; Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, California, United States of America., Atkins CM; Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

Publikováno v: PloS one [PLoS One] 2019 Oct 03; Vol. 14 (10), pp. e0223180. Date of Electronic Publication: 2019 Oct 03 (Print Publication: 2019).