Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Hofstead, Sandra J"'
Autor:
Zawadzke, Laura E, Wu, Ping, Cook, Lynda, Fan, Li, Casperson, Margaret, Kishnani, Mona, Calambur, Deepa, Hofstead, Sandra J, Padmanabha, Ramesh
Publikováno v:
In Analytical Biochemistry 2003 314(2):243-252
Autor:
Lynda S. Cook, Laura Zawadzke, Ramesh Padmanabha, Ping Wu, Margaret Casperson, Li Fan, Mona Kishnani, Deepa Calambur, Hofstead Sandra J
Publikováno v:
Analytical Biochemistry. 314:243-252
Assays for two enzymes from Escherichia coli were developed and validated as antibacterial inhibitor screens. The MraY and MurG enzymes were overexpressed and purified as the membrane fraction or to homogeneity, respectively. The MurG enzyme was expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd7dc7293a579b40034c3417bc5f4de
https://doi.org/10.1016/s0003-2697(02)00622-x
https://doi.org/10.1016/s0003-2697(02)00622-x
Autor:
Pamela A. Trail, Harold Mastalerz, Raymond A. Firestone, David Willner, Hofstead Sandra J, Shirley J. Lasch, Dalton King, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 45:4336-4343
High mole ratio BR96 immunoconjugates were synthesized using branched peptide-doxorubicin linkers designed to liberate doxorubicin following antigen-specific internalization into lysosomes. However, these immunoconjugates are highly prone to noncoval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29fb0884a9989d4a2ec907eb30cf07f
https://doi.org/10.1021/jm020149g
https://doi.org/10.1021/jm020149g
Autor:
Michael A. Walker, Shilpa Radia, Dalton King, Shirley J. Lasch, David Willner, Hofstead Sandra J, Gene M. Dubowchik, Harold Mastalerz, Raymond A. Firestone, Pamela A. Trail
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1529-1532
Bivalent doxorubicin (DOX)-dipeptides ( 16a – c ) were prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates. Conjugate 18b demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933401d420d7b01374ef7d812e2fa84b
https://doi.org/10.1016/s0960-894x(02)00194-4
https://doi.org/10.1016/s0960-894x(02)00194-4
Autor:
David Willner, Gary R. Braslawsky, Greenfield Robert S, Shirley J. Lasch, Anna Maria Casazza, Hofstead Sandra J, Ingegerd Hellström, Raymond A. Firestone, Karl Erik Hellström, Pamela A. Trail, Arris J. Henderson, Takushi Kaneko, King Hd
Publikováno v:
Journal of Controlled Release. 39:251-259
BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a modified Le y Ag on tumor cells, which then internalize it via endocytosis into lysosomes. There,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9bd0cf5063635932136c3bfc6102d4
https://doi.org/10.1016/0168-3659(95)00160-3
https://doi.org/10.1016/0168-3659(95)00160-3
Autor:
David Willner, Greenfield Robert S, Shirley J. Lasch, Hofstead Sandra J, Pamela A. Trail, King Hd, Raymond A. Firestone, Takushi Kaneko, Braslawsky Gary R
Publikováno v:
Bioconjugate Chemistry. 4:521-527
The (6-maleimidocaproyl)hydrazone of doxorubicin was synthesized and conjugated to several mAbs, including chimeric BR96, via a Michael addition reaction to thiol-containing mAbs. DTT reduction of disulfides present in the mAb was a reliable and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d376fa23fd2adcf44afcec9d99262a04
https://doi.org/10.1021/bc00024a015
https://doi.org/10.1021/bc00024a015
Autor:
Stella Huang, David R. Langley, Hofstead Sandra J, Kimberly L. Colson, Jerzy Golik, Daniel R. Schroeder, Steven E. Klohr, John E. Leet, Mike S. Lee
Publikováno v:
Journal of the American Chemical Society. 115:8432-8443
Kedarcidin, a new chromoprotein antitumor antibiotic, was isolated from the fermentation broth of a novel actinomycete strain. Kedarcidin consists of a water-soluble apoprotein and a solvent-extractable, cytotoxic, and highly unstable chromophore. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a745ab913479f32eb69a3db7131049
https://doi.org/10.1021/ja00071a062
https://doi.org/10.1021/ja00071a062
Autor:
Daniel R. Schroeder, John E. Leet, James A. Matson, Stella Huang, Jerzy Golik, Hofstead Sandra J, Kimberly L. Colson, Terrence W. Doyle, Steven E. Klohr
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89e8e1e6dc97a7ad6643ff6eda49a318
https://doi.org/10.1002/chin.199303279
https://doi.org/10.1002/chin.199303279
Publikováno v:
Tetrahedron Letters. 33:6107-6110
The structure of kedarosamine, the amino sugar moiety of kedarcidin chromophore, was established by NMR spectroscopy and X-ray crystallography as 2,4 dideoxy-4-(dimethylamino)-L-fucopyranose. bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3587db079840ea44f66b61d8793674a2
https://doi.org/10.1016/s0040-4039(00)60018-7
https://doi.org/10.1016/s0040-4039(00)60018-7
Autor:
Wenying Li, Christopher L. Steele, Zizhuo Xing, Brian A. Dougherty, Hofstead Sandra J, Yijun Chen, Kin Sing Lam, Shu-Jen Chiang
Publikováno v:
Archives of biochemistry and biophysics. 438(1)
The conversion of α-phenylalanine to β-phenylalanine is the first committed step in the biosynthesis of the C-13 side chain of Taxol. Thus, the novel enzyme responsible for this step, phenylalanine aminomutase (PAM), is of considerable interest for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7c153b85ed3720df636551807a24cf
https://pubmed.ncbi.nlm.nih.gov/15878763
https://pubmed.ncbi.nlm.nih.gov/15878763