Microbiome Depletion Increases Fentanyl Self-Administration and Alters the Striatal Proteome Through Short-Chain Fatty Acids.

Autor: Hofford RS; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Meckel KR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Wiser EJ; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101., Wang W; Keck MS & Proteomics Resource, Yale University School of Medicine, New Haven, CT 06520., Sens JP; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101., Kim M; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Godino A; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029., Lam TT; Keck MS & Proteomics Resource, Yale University School of Medicine, New Haven, CT 06520.; Yale/NIDA Neuroproteomics Center, Yale University School of Medicine, New Haven, CT 06520.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520., Kiraly DD; Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC 27101 dkiraly@wakehealth.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029.; Department of Psychiatry, Atrium Health Wake Forest Baptist, Winston-Salem, NC 27101.

Publikováno v: ENeuro [eNeuro] 2024 Feb 15; Vol. 11 (2). Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).

Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking.

Autor: Meckel KR; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Biology, Swarthmore College, Swarthmore, PA, 19081, USA., Simpson SS; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Godino A; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Peck EG; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA., Sens JP; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA., Leonard MZ; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA., George O; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Calipari ES; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, 865F Light Hall, 2215 Garland Avenue, Nashville, TN, 37232, USA.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.; Department of Psychiatry and Behavioral Sciences, Vanderbilt University, Nashville, TN, USA., Hofford RS; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kiraly DD; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Department of Physiology & Pharmacology, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA. dkiraly@wakehealth.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dkiraly@wakehealth.edu.; Department of Psychiatry, Wake Forest University School of Medicine, Atrium Wake Forest Baptist Health, Winston-Salem, NC, 27101, USA. dkiraly@wakehealth.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Jan; Vol. 49 (2), pp. 386-395. Date of Electronic Publication: 2023 Aug 02.

Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine.

Autor: Osman A; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hofford RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Physiology, Pharmacology and Psychiatry, Wake Forest School of Medicine, 115 S. Chestnut Street, Winston-Salem, NC, 27104, USA., Meckel KR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dave YA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zeldin SM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shipman AL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lucerne KE; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Trageser KJ; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA., Oguchi T; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA., Kiraly DD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dkiraly@wakehealth.edu.; The Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dkiraly@wakehealth.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dkiraly@wakehealth.edu.; Department of Physiology, Pharmacology and Psychiatry, Wake Forest School of Medicine, 115 S. Chestnut Street, Winston-Salem, NC, 27104, USA. dkiraly@wakehealth.edu.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dkiraly@wakehealth.edu.; Department of Psychiatry, Atrium Health Wake Forest Baptist, Winston-Salem, NC, USA. dkiraly@wakehealth.edu.

Publikováno v: Scientific reports [Sci Rep] 2023 Jul 27; Vol. 13 (1), pp. 12223. Date of Electronic Publication: 2023 Jul 27.

Alterations in microbiome composition and metabolic byproducts drive behavioral and transcriptional responses to morphine.

Autor: Hofford RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mervosh NL; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Euston TJ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Meckel KR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Orr AT; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kiraly DD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. drew.kiraly@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. drew.kiraly@mssm.edu.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. drew.kiraly@mssm.edu.; The Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. drew.kiraly@mssm.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2021 Nov; Vol. 46 (12), pp. 2062-2072. Date of Electronic Publication: 2021 Jun 14.

Granulocyte-Colony Stimulating Factor Reduces Cocaine-Seeking and Downregulates Glutamatergic Synaptic Proteins in Medial Prefrontal Cortex.

Autor: Hofford RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Euston TJ; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Wilson RS; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510.; WM Keck Biotechnology Resource Laboratory, Yale University, New Haven, Connecticut 06510., Meckel KR; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Peck EG; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101., Godino A; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Landry JA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029., Calipari ES; Departments of Pharmacology.; Molecular Physiology and Biophysics.; Psychiatry and Behavioral Sciences, Vanderbilt University, Nashville, Tennessee 37232.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, Tennessee 37232.; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, Tennessee 37232.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University, Nashville, Tennessee 37232., Lam TT; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510.; WM Keck Biotechnology Resource Laboratory, Yale University, New Haven, Connecticut 06510., Kiraly DD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029 drew.kiraly@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029.; Seaver Center for Autism, Icahn School of Medicine at Mount Sinai, New York, New York 10029.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Feb 17; Vol. 41 (7), pp. 1553-1565. Date of Electronic Publication: 2020 Dec 23.