Oligomerization and fibrillization properties of amyloid peptides and interactions with inhibitors

Autor: Hoffmann, Anais

Les maladies amyloïdes sont des affections sévères caractérisées par la présence de dépôts extracellulaires fibreux susceptibles de toucher un ou plusieurs tissus du corps humain. Au cours de ma thèse, je me suis intéressée au peptide β a

Externí odkaz: http://www.theses.fr/2015PA066442/document

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Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus

Autor: Caillon, Lucie, Hoffmann, Anais R. F., Botz, Alexandra, Khemtemourian, Lucie

Publikováno v: Journal of Diabetes Research.

Human islet amyloid polypeptide (hIAPP) is the major component of the amyloid deposits found in the pancreatic islets of patients with type 2 diabetes mellitus (T2DM). Mature hIAPP, a 37-aa peptide, is natively unfolded in its monomeric state but for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=hindawi_publ::4a5be1821d8ad9a527968945424ecbb5

(R)-alpha-Trifluoromethylalanine Containing Short Peptide in the Inhibition of Amyloid Peptide Fibrillation

Autor: Botz, Alexandra, Gasparik, Vincent, Devillers, Emmanuelle, Hoffmann, Anais R. F., Caillon, Lucie, Chelain, Evelyne, Lequin, Olivier, Brigaud, Thierry, Khemtemourian, Lucie

Publikováno v: Biopolymers
Biopolymers, Wiley, 2015, 104 (5, SI), pp.601-610. ⟨10.1002/bip.22670⟩
Biopolymers, 2015, 104 (5, SI), pp.601-610. ⟨10.1002/bip.22670⟩

International audience; The extracellular deposition of insoluble amyloid fibrils resulting from the aggregation of the amyloid-beta (A beta) is a pathological feature of neuronal loss in Alzheimer's disease (AD). Numerous small molecules have been r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a22e8f271de9fda84b337e75200abe09
https://hal.archives-ouvertes.fr/hal-01366197

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