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FOXO1‐RICTOR AXIS INDUCES AKT PHOSPHORYLATION DURING CLL CELL ADAPTATION TO BCR INHIBITORS: IMPLICATIONS FOR COMBINATORIAL THERAPY.

Autor: Ondrisova, L., Seda, V., Hoferkova, E., Chiodin, G., Hlavac, K., Kostalova, L., Pavlasova, G. Mladonicka, Filip, D., Zeni, P. Faria, Oppelt, J., Panovska, A., Plevova, K., Pospisilova, S., Simkovic, M., Vrbacky, F., Lysak, D., Fernandes, S. M., Davids, M. S., Maiques‐Diaz, A., Charalampopoulou, S.

Publikováno v: Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p54-56, 3p

FoxO1/Rictor axis induces a non-genetic adaptation to Ibrutinib via Akt activation in chronic lymphocytic leukemia.

Autor: Ondrisova L; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Seda V; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Hlavac K; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Pavelkova P; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Hoferkova E; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Chiodin G; Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom., Kostalova L; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Mladonicka Pavlasova G; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Filip D; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Vecera J; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Zeni PF; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Oppelt J; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic., Kahounova Z; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic., Vichova R; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic., Soucek K; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic., Panovska A; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Plevova K; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Pospisilova S; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Simkovic M; 4th Department of Internal Medicine - Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czech Republic., Vrbacky F; 4th Department of Internal Medicine - Haematology, University Hospital Hradec Kralove and Faculty of Medicine Hradec Kralove, Charles University, Prague, Czech Republic., Lysak D; Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech Republic., Fernandes SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America., Davids MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America., Maiques-Diaz A; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Charalampopoulou S; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Martin-Subero JI; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States of America., Doubek M; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Forconi F; Cancer Science Unit, University of Southampton, Southampton, United Kingdom., Mayer J; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Mraz M; Molecular Medicine, CEITEC Masaryk University, Brno, Czech Republic.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Oct 22. Date of Electronic Publication: 2024 Oct 22.