Výsledky vyhledávání - "Hofbauer cells"

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Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment

Autor: Lydia L. Shook, Rebecca E. Batorsky, Rose M. De Guzman, Liam T. McCrea, Sara M. Brigida, Joy E. Horng, Steven D. Sheridan, Olha Kholod, Aidan M. Cook, Jonathan Z. Li, Donna K. Slonim, Brittany A. Goods, Roy H. Perlis, Andrea G. Edlow

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)

Abstract Background The SARS-CoV-2 virus activates maternal and placental immune responses. Such activation in the setting of other infections during pregnancy is known to impact fetal brain development. The effects of maternal immune activation on n

Externí odkaz: https://doaj.org/article/36803db3dda24d3984f9b94b2c6037ad

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Proteomic studies of VEGFR2 in human placentas reveal protein associations with preeclampsia, diabetes, gravidity, and labor

Autor: Shannon J. Ho, Dale Chaput, Rachel G. Sinkey, Amanda H. Garces, Erika P. New, Maja Okuka, Peng Sang, Sefa Arlier, Nihan Semerci, Thora S. Steffensen, Thomas J. Rutherford, Angel E. Alsina, Jianfeng Cai, Matthew L. Anderson, Ronald R. Magness, Vladimir N. Uversky, Derek A. T. Cummings, John C. M. Tsibris

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)

Abstract VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental angiogenesis. The study of the VEGFR2 proteome of chorionic villi at term revealed its partners MDMX (Double minute 4 protein) and PICALM (Phosphatidy

Externí odkaz: https://doaj.org/article/4a1dc85d29c94f1b8404ba416c726589

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The interplay of inflammation and placenta in maternal diabetes: insights into Hofbauer cell expression patterns

Autor: Zdenek Tauber, Adela Burianova, Katerina Koubova, Max Mrstik, Marie Jirkovska, Katerina Cizkova

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInflammation of the placenta is harmful to both the fetus and the mother. Inflammation is strongly associated with diabetes, a common complication of pregnancy. Hofbauer cells (HBCs), unique immune system cells of fetal origin in the plac

Externí odkaz: https://doaj.org/article/93c2e762fe034c38b9dc47ed1ac14d48

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CD68 expression in the placenta of gestational diabetic mothers: A case–control study

Autor: Ratna Gosain, Rohini Motwani, Hari Anupama

Publikováno v: Indian Journal of Pathology and Microbiology, Vol 66, Iss 4, Pp 727-731 (2023)

Background: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with the onset or first recognition during pregnancy and is the most common metabolic complication of pregnancy. Significant maternal and fetal complicati

Externí odkaz: https://doaj.org/article/2b8770b0549248928ca56151878f0b76

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Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals

Autor: Alexandra D. Goudreau, Catherine Everest, Layli Tanara, Velislava Tzaneva, Kristi B. Adamo

Publikováno v: Physiological Reports, Vol 11, Iss 11, Pp n/a-n/a (2023)

Abstract Physical activity (PA) during pregnancy is associated with parental and fetal health benefits; however, the mechanisms through which these benefits arise are yet to be fully understood. In healthy pregnancies Hofbauer cells (HBCs) comprise a

Externí odkaz: https://doaj.org/article/7b8b674c2a0c4d45ae94b29fd1520df3

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Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis

Autor: Asli Ozmen, Chinedu Nwabuobi, Zhonghua Tang, Xiaofang Guo, Kellie Larsen, Seth Guller, Jacqueline Blas, Monica Moore, Umit A. Kayisli, Charles J. Lockwood, Ozlem Guzeloglu-Kayisli

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 1, p 135 (2023)

Leptin plays a crucial role in regulating energy homoeostasis, neuroendocrine function, metabolism, and immune and inflammatory responses. The adipose tissue is a main source of leptin, but during pregnancy, leptin is also secreted primarily by the p

Externí odkaz: https://doaj.org/article/b113f7b22ec640d09a29674aa2d5e85e

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Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling

Autor: Yueyue Zhu, Xiaorui Liu, Yichi Xu, Yi Lin

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regula

Externí odkaz: https://doaj.org/article/ed3d0ed1b6b24bc09588b58fbcbf4f7a

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