A linear mixed-model approach to study multivariate gene–environment interactions

Autor: 't Hoen, P.A., van Meurs, Joyce B J, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, D.I., Pool, R., van Dongen, J., Hottenga, J.J., Van Greevenbroek, Marleen J., Stehouwer, Coen D A, van der Kallen, Carla J H, Schalkwijk, Casper G, Wijmenga, Cisca, Zhernakova, Alexandra, Tigchelaar, Ettje F, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H, van den Berg, Leonard H, van Duijn, Cornelia M, Hofman, Bert A., Uitterlinden, Andre G, Jhamai, P Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V., Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, P. Szymon M., Swertz, Morris a., van Zwet, Erik W

Publikováno v: Moore, R, Casale, F P, Jan Bonder, M, Horta, D, Franke, L, Barroso, I, Stegle, O & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene–environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0
Nature Genetics, 51(1), 180-186. Nature Publishing Group
't Hoen, P A, van Meurs, J B J, Isaacs, A, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Van Greevenbroek, M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, A, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Iterson, M, van Galen, M, Bot, J, van’t Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Zhernakova, D V, Luijk, R, Jan Bonder, M, van Dijk, F, Arindrarto, W, Kielbasa, P S M, Swertz, M A, van Zwet, E W & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene-environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0

Different environmental factors, including diet, physical activity, or external conditions can contribute to genotype-environment interactions (GxE). Although high-dimensional environmental data are increasingly available, and multiple environments h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329339e0424884e7221abf5b507b437e
https://research.vumc.nl/en/publications/bc3d6aef-b18e-4156-b939-0c5e6c101469

Identification and Functional Investigation of SOX4 as a Novel Gene Underpinning Familial Atrial Fibrillation.

Autor: Jiang, Wei-Feng¹ (AUTHOR) wf.jiang@hotmail.com, Sun, Yu-Min² (AUTHOR) sunyumin@fudan.edu.cn, Qiu, Xing-Biao³ (AUTHOR) qiuxingbiao@hotmail.com, Wu, Shao-Hui³ (AUTHOR) wushaohui18@163.com, Ding, Yuan-Yuan⁴ (AUTHOR) dingyuanyuan@shdrc.org, Li, Ning⁵ (AUTHOR) frankleelx@163.com, Yang, Chen-Xi^6,7,8 (AUTHOR) 13472626672@163.com, Xu, Ying-Jia^6,7,8 (AUTHOR) xuyingjia@5thhospital.com, Jiang, Ting-Bo¹ (AUTHOR) jtbsdfyy@163.com, Yang, Yi-Qing^6,7,8,9 (AUTHOR) jtbsdfyy@163.com

Publikováno v: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 21, p2376. 20p.

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes:analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign

Autor: Hoen, P.A., Commandeur, J N, Vermeulen, N P, van Berkel, T.J., Bijsterbosch, Martin K

Publikováno v: Hoen, P A, Commandeur, J N, Vermeulen, N P, van Berkel, T J & Bijsterbosch, M K 2000, ' Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes : analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign ', Biochemical Pharmacology, vol. 60, no. 10, pp. 1509-18 . https://doi.org/10.1016/S0006-2952(00)00454-8
ResearcherID
Biochemical Pharmacology, 60(10), 1509-18. Elsevier Inc.

The study of drug metabolism in cultured rat hepatocytes is hampered by the rapid loss of the expression of cytochrome P450 enzymes. Nevertheless, the activity of cytochrome P450 3A (CYP3A), one of the most important isoenzymes for drug metabolism, c

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https://research.vu.nl/en/publications/0a867c7e-2dce-4a48-aaa1-66ed4274a1ec

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?

Autor: Kobayashi-Ishihara, Mie¹ (AUTHOR) mieki@keio.jp, Tsunetsugu-Yokota, Yasuko² (AUTHOR) mieki@keio.jp

Publikováno v: Viruses (1999-4915). May2024, Vol. 16 Issue 5, p666. 15p.

LXR Agonist T0901317′s Hepatic Impact Overrules Its Atheroprotective Action in Macrophages, Driving Early Atherogenesis in Chow-Diet-Fed Male Apolipoprotein E Knockout Mice.

Autor: Hoekstra, Menno^1,2,3 (AUTHOR) hoekstra@lacdr.leidenuniv.nl, de Jong, Laura M.¹ (AUTHOR) m.eck@lacdr.leidenuniv.nl, van der Geest, Rick¹ (AUTHOR), de Leeuw, Lidewij R.¹ (AUTHOR), Krisnamurthi, Rani¹ (AUTHOR), Geerling, Janine J.¹ (AUTHOR), Van Eck, Miranda^1,2,3 (AUTHOR)

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