Bioavailability, Biodistribution, and CNS Toxicity of Clinical-Grade Parvovirus H1 after Intravenous and Intracerebral Injection in Rats

Autor: Geletneky, Karsten, Leoni, Anne-Laure, Pohlmeyer-Esch, Gabriele, Loebhard, Stephanie, Leuchs, Barbara, Hoefer, Constance, Jochims, Karin, Dahm, Michael, Huber, Bernard, Rommelaere, Jean, Krebs, Ottheinz, Hajda, Jacek

The autonomous parvovirus H1 (H1PV) is transmitted in rodent populations. The natural host is the rat, in which H1PV infection is pathogenic only in fetuses and newborns. H1PV infection of human cancer cells leads to strong oncolytic effects in precl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c520aa8ba9c774c4f03bc311080168d
https://europepmc.org/articles/PMC4396927/

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Pathology, organ distribution, and immune response after single and repeated intravenous injection of rats with clinical-grade parvovirus H1.

Autor: Geletneky K; Department of Neurosurgery, University Hospital, Heidelberg, Germany; Department of Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany. kgeletneky@med.uni-heidelberg.de., Leoni AL; BSL BIOSERVICE Scientific Laboratories GmbH, Planegg, Munich, Germany., Pohlmeyer-Esch G; KALEIDIS Consultancy in Histopathology, Saint Louis, France., Loebhard S; BSL BIOSERVICE Scientific Laboratories GmbH, Planegg, Munich, Germany., Baetz A; BSL BIOSERVICE Scientific Laboratories GmbH, Planegg, Munich, Germany., Leuchs B; Department of Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany., Roscher M; Department of Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany., Hoefer C; DMPKORE, Ingolstadt, Germany., Jochims K; IASON Consulting, Niederzier, Germany., Dahm M; ORYX GmbH and Co KG, Baldham, Germany., Huber B; ORYX GmbH and Co KG, Baldham, Germany., Rommelaere J; Department of Applied Tumor Virology, German Cancer Research Center, Heidelberg, Germany., Krebs O; ORYX GmbH and Co KG, Baldham, Germany., Hajda J; Coordination Center for Clinical Trials, University Hospital, Heidelberg, Germany.

Publikováno v: Comparative medicine [Comp Med] 2015 Feb; Vol. 65 (1), pp. 23-35.