Candidate Genes for Nonsyndromic Cleft Palate Detected by Exome Sequencing.

Autor: Hoebel AK; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Drichel D; 3 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; 4 Cologne Center for Genomics, Department of Statistical Genetics and Bioinformatics, University of Cologne, Cologne, Germany., van de Vorst M; 5 Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Böhmer AC; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Sivalingam S; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Ishorst N; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Klamt J; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Gölz L; 6 Department of Orthodontics, University of Bonn, Bonn, Germany., Alblas M; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Maaser A; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Keppler K; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Zink AM; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany., Dixon MJ; 7 Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK., Dixon J; 7 Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK., Hemprich A; 8 Department of Oral and Maxillo-Facial Surgery, University of Leipzig, Leipzig, Germany., Kruse T; 9 Department of Orthodontics, University of Cologne, Cologne, Germany., Graf I; 9 Department of Orthodontics, University of Cologne, Cologne, Germany., Dunsche A; 10 Clinics Karlsruhe, Department of Oral and Maxillo-Facial Surgery, Karlsruhe, Germany., Schmidt G; 11 Department of Cleft Lip and Cleft Palate Surgery, Humboldt University of Berlin, Berlin, Germany., Daratsianos N; 6 Department of Orthodontics, University of Bonn, Bonn, Germany., Nowak S; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany., Aldhorae KA; 12 Department of Orthodontics, College of Dentistry, Dhamar University, Dhamar, Yemen., Nöthen MM; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany., Knapp M; 13 Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Thiele H; 14 Cologne Center for Genomics, University of Cologne, Cologne, Germany., Gilissen C; 5 Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Reutter H; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 15 Department of Neonatology &Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany., Hoischen A; 5 Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.; 16 Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.; 17 Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Mangold E; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany., Ludwig KU; 1 Institute of Human Genetics, University of Bonn, Bonn, Germany.; 2 Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.

Publikováno v: Journal of dental research [J Dent Res] 2017 Oct; Vol. 96 (11), pp. 1314-1321. Date of Electronic Publication: 2017 Aug 02.

Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate.

Autor: Mangold E; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. Electronic address: e.mangold@uni-bonn.de., Böhmer AC; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Ishorst N; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Hoebel AK; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Gültepe P; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Schuenke H; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Klamt J; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Hofmann A; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Gölz L; Department of Orthodontics, University of Bonn, 53127 Bonn, Germany., Raff R; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Tessmann P; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Nowak S; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany., Reutter H; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany; Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, 53113 Bonn, Germany., Hemprich A; Clinic for Maxillofacial Surgery, University Hospital Leipzig, 04103 Leipzig, Germany., Kreusch T; Department of Oral and Maxillofacial Surgery, Head and Neck Centre, Asklepios Klinik Nord, Heidberg, 22417 Hamburg, Germany., Kramer FJ; Department of Oral and Maxillofacial Surgery, University of Göttingen, 37075 Göttingen, Germany., Braumann B; Department of Orthodontics, University of Cologne, 50931 Cologne, Germany., Reich R; Department of Oral and Maxillo-Facial-Plastic Surgery, University of Bonn, 53111 Bonn, Germany., Schmidt G; Department of Cleft Lip and Cleft Palate Surgery, Humboldt University of Berlin, 13353 Berlin, Germany., Jäger A; Department of Orthodontics, University of Bonn, 53127 Bonn, Germany., Reiter R; Section of Phoniatrics and Pedaudiology, Department of Otolaryngology - Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany., Brosch S; Section of Phoniatrics and Pedaudiology, Department of Otolaryngology - Head and Neck Surgery, University of Ulm, 89070 Ulm, Germany., Stavusis J; Medical Genetics and Mitochondrial Research Group, Latvian Biomedical Research and Study Centre, Riga 1067, Latvia., Ishida M; Institute of Child Health, University College London, London WC1N 1EH, UK., Seselgyte R; Institute of Child Health, University College London, London WC1N 1EH, UK., Moore GE; Institute of Child Health, University College London, London WC1N 1EH, UK., Nöthen MM; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany., Borck G; Institute of Human Genetics, Ulm University, 89073 Ulm, Germany., Aldhorae KA; Orthodontic Department, College of Dentistry, Thamar University, Thamar, Yemen., Lace B; Medical Genetics and Mitochondrial Research Group, Latvian Biomedical Research and Study Centre, Riga 1067, Latvia., Stanier P; Institute of Child Health, University College London, London WC1N 1EH, UK., Knapp M; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, 53127 Bonn, Germany., Ludwig KU; Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2016 Apr 07; Vol. 98 (4), pp. 755-62. Date of Electronic Publication: 2016 Mar 24.