NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.

Autor: Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK., Pentinmikko N; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Luopajärvi K; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Willis NJ; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK., Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA., Raven AP; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA., Mcgarry L; Cancer Research UK Beatson Institute, Glasgow, UK., Englund JI; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Webb AT; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden., Scharaw S; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden., Nasreddin N; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Hodder MC; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK., Minnee E; Cancer Research UK Beatson Institute, Glasgow, UK.; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Sphyris N; Cancer Research UK Beatson Institute, Glasgow, UK., Gilchrist E; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK., Romagnolo B; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France., Perret C; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France., Williams AC; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK., Clevers H; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands., Nummela P; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Lähde M; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland., Alitalo K; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland., Hietakangas V; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Hedley A; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK., Kirschner K; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ristimäki A; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Leedham SJ; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.; The Francis Crick Institute, London, UK., Vincent JP; The Francis Crick Institute, London, UK., Katajisto P; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@helsinki.fi., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk.

Publikováno v: Nature [Nature] 2021 Jun; Vol. 594 (7863), pp. 430-435. Date of Electronic Publication: 2021 Jun 02.

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.

Autor: Healy ME; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Boege Y; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Hodder MC; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: achim.weber@usz.ch., Böhm F; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Malehmir M; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Scherr AL; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Jetzer J; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Chan LK; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Parrotta R; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Jacobs K; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Clerbaux LA; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Kreutzer S; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Campbell A; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Gilchrist E; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Gilroy K; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Rodewald AK; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Honcharova-Biletska H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Schimmer R; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Vélez K; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Büeler S; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Cammareri P; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Kalna G; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK., Wenning AS; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., McCoy KD; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland; Department of Physiology and Pharmacology and Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Gomez de Agüero M; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., Schulze-Bergkamen H; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Klose CSN; Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Germany., Unger K; Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, Neuherberg Germany., Macpherson AJ; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Bern, Switzerland., Moor AE; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Köhler B; National Center for Tumor Diseases, Department of Medical Oncology and Heidelberg University Hospital, Internal Medicine VI, Heidelberg, Germany., Sansom OJ; Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK. Electronic address: o.sansom@beatson.gla.ac.uk., Heikenwälder M; Division of Chronic Inflammation and Cancer, Deutsches Krebs-Forschungszentrum (DKFZ), Heidelberg, Germany. Electronic address: m.heikenwaelder@dkfz.de., Weber A; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland. Electronic address: achim.weber@usz.ch.

Publikováno v: Gastroenterology [Gastroenterology] 2020 Jul; Vol. 159 (1), pp. 183-199. Date of Electronic Publication: 2020 Mar 14.

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Autor: Gay DM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Ridgway RA; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Müller M; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Hodder MC; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Hedley A; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Clark W; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Leach JD; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Jackstadt R; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Nixon C; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Huels DJ; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; Academic Medical Center (AMC), University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands., Campbell AD; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Bird TG; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, UK.; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Sansom OJ; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, UK. o.sansom@beatson.gla.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Mar 26; Vol. 10 (1), pp. 1453. Date of Electronic Publication: 2019 Mar 26.

Microenvironmental cues in cancer stemness.

Autor: Flanagan DJ; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, Scotland, UK., Hodder MC; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, Scotland, UK., Sansom OJ; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, Scotland, UK. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK. o.sansom@beatson.gla.ac.uk.

Publikováno v: Nature cell biology [Nat Cell Biol] 2018 Oct; Vol. 20 (10), pp. 1102-1104.

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.

Autor: Huels DJ; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Bruens L; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT, Utrecht, The Netherlands.; Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066CX, Amsterdam, The Netherlands.; Center for Molecular Medicine, Oncode Institute, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands., Hodder MC; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Cammareri P; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Campbell AD; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Ridgway RA; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Gay DM; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Solar-Abboud M; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Faller WJ; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Nixon C; CRUK Beatson Institute, Glasgow, G61 1BD, UK., Zeiger LB; CRUK Beatson Institute, Glasgow, G61 1BD, UK., McLaughlin ME; Oncology Translational Research, Novartis Institutes for Biomedical Research, Cambridge, MA, 02139, USA., Morrissey E; MRC Weatherall Institute of Molecular Medicine University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK., Winton DJ; CRUK Cambridge Institute, Cambridge, CB2 0RE, UK., Snippert HJ; Center for Molecular Medicine, Oncode Institute, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands., van Rheenen J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT, Utrecht, The Netherlands.; Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066CX, Amsterdam, The Netherlands., Sansom OJ; CRUK Beatson Institute, Glasgow, G61 1BD, UK. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences (ICS), University of Glasgow, Glasgow, G12 8QQ, UK. o.sansom@beatson.gla.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Mar 19; Vol. 9 (1), pp. 1132. Date of Electronic Publication: 2018 Mar 19.