Výsledky vyhledávání - "Hoda I, El Diwani"

Akademický článek

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

Autor: Heba T. Abdel-Mohsen, Mona A. Abdullaziz, Ahmed M. El Kerdawy, Fatma A. F. Ragab, Keith J. Flanagan, Abeer E. E. Mahmoud, Mamdouh M. Ali, Hoda I. El Diwani, Mathias O. Senge

Publikováno v: Molecules, Vol 25, Iss 4, p 770 (2020)

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfu

Externí odkaz: https://doaj.org/article/d5681756020243118eccfbe786f07279

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Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors

Autor: Andrea Petreni, Claudiu T. Supuran, Rasha M. Allam, Ahmed M. El Kerdawy, Mohamed A. Omar, Hoda I. El Diwani, Heba T. Abdel‐Mohsen

Publikováno v: European journal of medicinal chemistry. 228

A dual-tail approach was applied to the design of a novel series of 2-thiopyrimidine–benzenesulfonamides as carbonic anhydrase (CA) inhibitors. The design strategy is based on the hybridization between a benzenesulfonamide moiety as Zn2+ binding gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c4bce89eb7c19fbbeabd540ce8bad7
https://pubmed.ncbi.nlm.nih.gov/34847409

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Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor

Autor: Fatma A.F. Ragab, Ahmed S. Abdelsamie, Sonam Roy, Anna K. H. Hirsch, Mohamed A. Omar, Shadia A. Galal, Imtaiyaz Hassan, Hoda I. El Diwani, Ahmad Abu Turab Naqvi, Sarah H. M. Khairat

Publikováno v: Archiv der PharmazieREFERENCES. 354(9)

Sphingosine kinase 1 (SphK1) has emerged as an attractive drug target for different diseases. Recently, discovered SphK1 inhibitors have been recommended in cancer therapeutics; however, selectivity and potency are great challenges. In this study, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c03c87ef4a485b2b2b1234966b67f27
https://pubmed.ncbi.nlm.nih.gov/34128259

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Design and synthesis of new pyrazolylbenzimidazoles as sphingosine 1-kinase inhibitors

Autor: Shadia A. Galal, Ahmad Abu Turab Naqvi, Hoda I. El Diwani, Fatma A.F. Ragab, Sarah H. M. Khairat, Sonam Roy, Mohamed A. Omar, Md. Imtaiyaz Hassan

Sphingosine-1 Kinase (SphK-1) is one of the important enzymes of phospholipids and it is inhibition is one of the therapeutic strategies for different diseases. SphK1 over expression is observed in different types of cancer that indicating its import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::247ebf9d0c9b1c9a12e132ecd89478cf
https://doi.org/10.21203/rs.3.rs-342383/v1

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Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors

Autor: Amal A. Fyiad, Abeer E. Mahmoud, Raghda Ramdan, Hoda I. El Diwani, Ashraf A Tabll, Yasmin M. Attia, Shadia A. Galal, Reem El-Shenawy, Samia A. Shouman, Hamed I. Ali, Sarah H. M. Khairat, Abeer H. Abdel-Halim, Mamdouh M. Ali, Yasmine S El Abd

Publikováno v: European Journal of Medicinal Chemistry. 144:859-873

The development of checkpoint kinase 2 (Chk2) inhibitors for the treatment of cancer has been an ongoing and attractive objective in drug discovery. In this study, twenty-one feasible pyrazole-benzimidazole conjugates were synthesized to study their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73d2108562fcc2f60d3e8e46caf4050
https://doi.org/10.1016/j.ejmech.2017.12.023

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New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies

Autor: Hoda I. El Diwani, Claudiu T. Supuran, Heba T. Abdel-Mohsen, Ahmed S. Abdelsamie, Ahmed M. El Kerdawy, Emanuela Berrino, Mohamed A. Omar

Publikováno v: Bioorganicmedicinal chemistry. 28(5)

In the present work, a new series of thiopyrimidine-benzenesulfonamide conjugates was designed, synthesized and tested as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. Our design strategy was based on the molecular hybridization of the benzenesulfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733c939edf4dc4e7f0304d23876e4494
https://pubmed.ncbi.nlm.nih.gov/32007388

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Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors

Autor: Ahmed M. El Kerdawy, Mohamed A. Omar, Heba T. Abdel-Mohsen, Mamdouh M. Ali, Abeer E. Mahmoud, Hoda I. El Diwani

Publikováno v: European journal of medicinal chemistry. 179

In the present study, we report the discovery of a novel class of substituted 4-amino-2-thiopyrimidines as antiangiogenic and antiproliferative agents. Structural hybridization between 4-substituted aminopyrimidines (VEGFR-2 inhibitors) and 2-thioxop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19546d57b661fcd58967799a484b73c4
https://pubmed.ncbi.nlm.nih.gov/31284081

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Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

Autor: Hoda I. El Diwani, Mona A. Abdullaziz, Abeer E. Mahmoud, Mathias O. Senge, Keith J. Flanagan, Fatma A.F. Ragab, Heba T. Abdel-Mohsen, Mamdouh M. Ali, Ahmed M. El Kerdawy

Publikováno v: Molecules
Molecules, Vol 25, Iss 4, p 770 (2020)
Volume 25
Issue 4

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold
it aimed first at studying the effect of replacing the 5-meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95ae0c9ce896e8271acfd93cb698b63
https://doi.org/10.3390/molecules25040770

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