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Akademický článek

Targeting MicroRNA Function in Respiratory Diseases: Mini-review

Autor: Steven eMaltby, Maximilian ePlank, Hock L Tay, Adam eCollison, Paul eFoster

Publikováno v: Frontiers in Physiology, Vol 7 (2016)

MicroRNAs (miRNAs) are small non-coding RNA molecules that modulate expression of the majority of genes by inhibiting protein translation. Growing literature has identified functional roles for miRNAs across a broad range of biological processes. As

Externí odkaz: https://doaj.org/article/9d6efc6e2da74391960b28bb1103e66c

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Akademický článek

Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.

Autor: Hock L Tay, Gerard E Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M Hansbro, Paul S Foster

Publikováno v: PLoS Pathogens, Vol 11, Iss 6, p e1004956 (2015)

[This corrects the article DOI: 10.1371/journal.ppat.1004549.].

Externí odkaz: https://doaj.org/article/0b6804e209b04824acd2042f60aca7f9

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Akademický článek

Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

Autor: Hock L Tay, Gerard E Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M Hansbro, Paul S Foster

Publikováno v: PLoS Pathogens, Vol 11, Iss 4, p e1004549 (2015)

Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes a

Externí odkaz: https://doaj.org/article/c320b1eee37d462e9cbe425d53e243a2

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Akademický článek

MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity.

Autor: Maximilian W Plank, Steven Maltby, Hock L Tay, Jessica Stewart, Fiona Eyers, Philip M Hansbro, Paul S Foster

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144810 (2015)

MicroRNAs are post-transcriptional regulators of gene expression that are differentially regulated during development and in inflammatory diseases. A role for miRNAs in allergic asthma is emerging and further investigation is required to determine wh

Externí odkaz: https://doaj.org/article/78686957c1254903a706059d07dd7d36

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Akademický článek

Activation of olfactory receptors on mouse pulmonary macrophages promotes monocyte chemotactic protein-1 production.

Autor: Jing Jing Li, Hock L Tay, Maximilian Plank, Ama-Tawiah Essilfie, Philip M Hansbro, Paul S Foster, Ming Yang

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80148 (2013)

BACKGROUND: Emerging evidence suggests that non-olfactory tissues and cells can express olfactory receptors (ORs), however, the exact function of ectopic OR expression remains unknown. We have previously shown in mouse models that a unique cooperatio

Externí odkaz: https://doaj.org/article/b3f52ab263d04f56ba918e7e712b7a7d

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Akademický článek

Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis

Autor: Paul S. Foster, Hock L. Tay, Brian G. Oliver

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)

Although aging and lung injury are linked to the development of idiopathic pulmonary fibrosis (IPF), the underlying pathognomonic processes predisposing to fibrotic lesions remain largely unknown. A deficiency in the ability of type 2 alveolar epithe

Externí odkaz: https://doaj.org/article/37b17addb9a14dde8fbda48fab2ca133

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Akademický článek

A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation

Autor: Fang Yuan, Lili Jiang, Qianyang Li, Leon Sokulsky, Yuanyuan Wanyan, Lingli Wang, Xiaojie Liu, Lujia Zhou, Hock L. Tay, Guojun Zhang, Ming Yang, Fuguang Li

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

BackgroundThe anti-inflammatory effect of an α7nAChR agonist, PNU-282987, has previously been explored in the context of inflammatory disease. However, the effects of PNU-282987 on type 2 innate lymphoid cells (ILC2s)-mediated allergic airway inflam

Externí odkaz: https://doaj.org/article/c8ed06041ec14458a68437ad18480aa1

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