Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hocheol Lim"'
Autor:
Jieon Hwang, Areum Park, Chinwoo Kim, Chang Gon Kim, Jaesung Kwak, Byungil Kim, Hyunjin Shin, Minhee Ku, Jaemoon Yang, Ayoung Baek, Jiwon Choi, Hocheol Lim, Kyoung Tai No, Xianghua Zhao, Uyeong Choi, Tae Il Kim, Kyu-Sung Jeong, Hyuk Lee, Sang Joon Shin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Dysregulation of iron metabolism is implicated in malignant transformation, cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory protein 2 (IRP2) preferentially regulates iron metabolism and pr
Externí odkaz:
https://doaj.org/article/610071ff27cb47faa5ea555a2fd21739
Autor:
Hocheol Lim
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract De novo molecular design is the process of searching chemical space for drug-like molecules with desired properties, and deep learning has been recognized as a promising solution. In this study, I developed an effective computational method
Externí odkaz:
https://doaj.org/article/f4cdd290a603447893d7439f4c1831f5
Autor:
Jieon Hwang, Areum Park, Chinwoo Kim, Chang Gon Kim, Jaesung Kwak, Byungil Kim, Hyunjin Shin, Minhee Ku, Jaemoon Yang, Ayoung Baek, Jiwon Choi, Hocheol Lim, Kyoung Tai No, Xianghua Zhao, Uyeong Choi, Tae Il Kim, Kyu-Sung Jeong, Hyuk Lee, Sang Joon Shin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/491d4341b9084aefbcec3cbcf34bdd68
Autor:
Hocheol Lim
Publikováno v:
Materials Today Advances, Vol 24, Iss , Pp 100529- (2024)
Greenhouse gas emissions, particularly carbon dioxide (CO2), pose a significant threat to the climate, driving global warming and numerous environmental issues. Ionic liquids (ILs) have gained attention for CO2 capture due to their tunable properties
Externí odkaz:
https://doaj.org/article/3f3d63747c164dc08aa72a63b621c7f4
Autor:
Hocheol Lim, Doo Hyung Kang, Jeonghoon Kim, Aidan Pellow-Jarman, Shane McFarthing, Rowan Pellow-Jarman, Hyeon-Nae Jeon, Byungdu Oh, June-Koo Kevin Rhee, Kyoung Tai No
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Quantum computers offer significant potential for complex system analysis, yet their application in large systems is hindered by limitations such as qubit availability and quantum hardware noise. While the variational quantum eigensolver (VQ
Externí odkaz:
https://doaj.org/article/dfd166ae7f7e4143acc2967d81ac3730
Autor:
Hocheol Lim, Kyoung Tai No
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background Monoclonal antibodies (mAbs) have been used as therapeutic agents, which must overcome many developability issues after the discovery from in vitro display libraries. Especially, polyreactive mAbs can strongly bind to a specific t
Externí odkaz:
https://doaj.org/article/3d2513a4031c4213ae01ca396b072fff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Quantum computing is expected to play an important role in solving the problem of huge computational costs in various applications by utilizing the collective properties of quantum states, including superposition, interference, and entanglem
Externí odkaz:
https://doaj.org/article/07a015d08a2e4a00b36b94289f19d22e
Autor:
Hocheol Lim, Hyeon-Nae Jeon, Seungcheol Lim, Yuil Jang, Taehee Kim, Hyein Cho, Jae-Gu Pan, Kyoung Tai No
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 788-798 (2022)
The importance of protein engineering in the research and development of biopharmaceuticals and biomaterials has increased. Machine learning in computer-aided protein engineering can markedly reduce the experimental effort in identifying optimal sequ
Externí odkaz:
https://doaj.org/article/46e43217550141708c48c32b971be256
Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
Autor:
Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Ky-Youb Nam, Kyoung Tai No
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1217-1225 (2019)
X-linked inhibitor of apoptosis protein (XIAP) is an important regulator of cancer cell survival whose BIR3 domain (XIAP-BIR3) recognizes the Smac N-terminal tetrapeptide sequence (AVPI), making it an attractive protein-protein interaction (PPI) targ
Externí odkaz:
https://doaj.org/article/8a0ad527699447c4abc973ae10dfc394
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4438 (2022)
Matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing endopeptidases involved in multiple cellular processes. Among the MMP isoforms, MMP-9 regulates cancer invasion, rheumatoid arthritis, and osteoarthritis by degrading extracellula
Externí odkaz:
https://doaj.org/article/90586593ed044741a35b82151d8e0300