Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Hoch NC"'
2
Akademický článek
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.
Autor: Latancia MT; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil; Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Electronic address: marcela.teatinlatancia@nih.gov., Leandro GDS; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: giovanabiousp@gmail.com., Bastos AU; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: uchibastos@yahoo.com.br., Moreno NC; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil; Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Electronic address: natalia.moreno@nih.gov., Ariwoola AA; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil; Department of Clinical and Experimental Oncology, Federal University of São Paulo (UNIFESP), São Paulo 04037-003, Brazil. Electronic address: adetayo.ariwoola@yahoo.com., Martins DJ; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil; Laboratory of Genomic Stability, Chemistry Institute at University, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: davijardimmartins@gmail.com., Ashton NW; Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Electronic address: nicholas_ashton@dfci.harvard.edu., Ribeiro VC; Laboratory of Genomic Stability, Chemistry Institute at University, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: victoriaribeiro@usp.br., Hoch NC; Laboratory of Genomic Stability, Chemistry Institute at University, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: nicolas@iq.usp.br., Rocha CRR; Department of Clinical and Experimental Oncology, Federal University of São Paulo (UNIFESP), São Paulo 04037-003, Brazil. Electronic address: clarissa.rocha@unifesp.br., Woodgate R; Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Electronic address: woodgate@nih.gov., Menck CFM; Laboratory of DNA Repair, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address: cfmmenck@usp.br.
Publikováno v: DNA repair [DNA Repair (Amst)] 2024 Sep; Vol. 141, pp. 103715. Date of Electronic Publication: 2024 Jul 18.
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3
Akademický článek
The PARP inhibitor rucaparib blocks SARS-CoV-2 virus binding to cells and the immune reaction in models of COVID-19.
Autor: Papp H; National Laboratory of Virology, University of Pécs, Pécs, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; Szentagothai Research Centre, University of Pécs, Pécs, Hungary., Tóth E; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; HUN-REN-DE Cell Biology and Signaling Research Group, Debrecen, Hungary., Bóvári-Biri J; Szentagothai Research Centre, University of Pécs, Pécs, Hungary.; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary., Bánfai K; Szentagothai Research Centre, University of Pécs, Pécs, Hungary.; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary., Juhász P; Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Mahdi M; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Russo LC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Bajusz D; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Budapest, Hungary., Sipos A; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; HUN-REN-DE Cell Biology and Signaling Research Group, Debrecen, Hungary., Petri L; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Budapest, Hungary., Szalai TV; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Budapest, Hungary.; Department of Inorganic and Analytical Chemistry, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary., Kemény Á; Szentagothai Research Centre, University of Pécs, Pécs, Hungary.; Department of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, Pécs, Hungary.; Department of Medical Biology, Medical School, Pécs, Hungary., Madai M; National Laboratory of Virology, University of Pécs, Pécs, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; Szentagothai Research Centre, University of Pécs, Pécs, Hungary., Kuczmog A; National Laboratory of Virology, University of Pécs, Pécs, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.; Szentagothai Research Centre, University of Pécs, Pécs, Hungary., Batta G; Department of Organic Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary., Mózner O; Doctoral School of Molecular Medicine, Semmelweis University, Budapest, Hungary.; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary., Vaskó D; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary., Hirsch E; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary., Bohus P; Erzsébet Hospital, Sátoraljaújhely, Hungary., Méhes G; Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Tőzsér J; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Curtin NJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Helyes Z; Department of Pharmacology and Pharmacotherapy, Medical School & Centre for Neuroscience, University of Pécs, Pécs, Hungary.; Hungarian Research Network, Chronic Pain Research Group, University of Pécs, Pécs, Hungary.; National Laboratory for Drug Research and Development, Budapest, Hungary., Tóth A; Section of Clinical Physiology, Department of Cardiology, University of Debrecen, Debrecen, Hungary., Hoch NC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Jakab F; National Laboratory of Virology, University of Pécs, Pécs, Hungary.; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary., Keserű GM; Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Budapest, Hungary.; Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary., Pongrácz JE; Szentagothai Research Centre, University of Pécs, Pécs, Hungary.; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pécs, Pécs, Hungary., Bai P; Szentagothai Research Centre, University of Pécs, Pécs, Hungary.; Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, Hungary.; Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Dec; Vol. 181 (23), pp. 4782-4803. Date of Electronic Publication: 2024 Aug 27.
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4
Akademický článek
Molecular mechanisms of cell death by parthanatos: More questions than answers.
Autor: Moura RD; Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, São Paulo, SP, Brasil., Mattos PD; Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, São Paulo, SP, Brasil., Valente PF; Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, São Paulo, SP, Brasil., Hoch NC; Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, São Paulo, SP, Brasil.
Publikováno v: Genetics and molecular biology [Genet Mol Biol] 2024 Aug 30; Vol. 47Suppl 1 (Suppl 1), pp. e20230357. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
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5
Akademický článek
Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story.
Autor: Matos IA; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., Dallazen JL; Department of Pharmacology, Institute of Biological Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Reis LR; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., Souza LF; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., Bevevino RC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., de Moura RD; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., Ronsein GE; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., Hoch NC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil., da Costa Júnior NB; Department of Chemistry, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Costa SKP; Department of Pharmacology, Institute of Biological Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Meotti FC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo 05508-000, Brazil.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 12012-12032. Date of Electronic Publication: 2024 Jul 11.
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6
Akademický článek
Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1.
Autor: Rijpkema KJ; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Schuller M; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom., van der Veer MS; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Rieken S; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Chang DLR; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Balić P; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Todorov A; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Minnee H; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Wijngaarden S; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Matos IA; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.; Departamento de Bioquímica, Instituto de Química, Universidade de Sao Paulo, Av. Prof. Lineu Prestes, 748, Cidade Universitária, Sao Paulo 055800-000, Brasil., Hoch NC; Departamento de Bioquímica, Instituto de Química, Universidade de Sao Paulo, Av. Prof. Lineu Prestes, 748, Cidade Universitária, Sao Paulo 055800-000, Brasil., Codée JDC; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., Ahel I; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom., Filippov DV; Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Publikováno v: Organic letters [Org Lett] 2024 Jul 12; Vol. 26 (27), pp. 5700-5704. Date of Electronic Publication: 2024 Jun 27.
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7
Akademický článek
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation.
Autor: Ribeiro VC; Department of Biochemistry, University of São Paulo, São Paulo, 05508-000, Brazil., Russo LC; Department of Biochemistry, University of São Paulo, São Paulo, 05508-000, Brazil., Hoch NC; Department of Biochemistry, University of São Paulo, São Paulo, 05508-000, Brazil. nicolas@iq.usp.br.
Publikováno v: The EMBO journal [EMBO J] 2024 Jul; Vol. 43 (14), pp. 2908-2928. Date of Electronic Publication: 2024 Jun 04.
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8
Akademický článek
Rothmund-Thomson syndrome, a disorder far from solved.
Autor: Martins DJ; Genomic Stability Unit, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Di Lazzaro Filho R; Center for Human Genome Studies, Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.; Dasa Genômica/Genera, Genômica, São Paulo, Brazil., Bertola DR; Center for Human Genome Studies, Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.; Genetics Unit, Department of Pediatrics, Faculty of Medicine, Children's Institute, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil., Hoch NC; Genomic Stability Unit, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Publikováno v: Frontiers in aging [Front Aging] 2023 Nov 10; Vol. 4, pp. 1296409. Date of Electronic Publication: 2023 Nov 10 (Print Publication: 2023).
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9
Akademický článek
Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome.
Autor: Di Lazzaro Filho R; Departamento de Genética e Biologia Evolutiva do Instituto de Biociências, Universidade de São Paulo, Sao Paulo, Brazil.; Genômica/Genera, Diagnósticos da América SA, Barueri, Brazil., Yamamoto GL; Genômica/Genera, Diagnósticos da América SA, Barueri, Brazil.; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Silva TJ; Departamento de Bioquímica do Instituto de Química, Universidade de Sao Paulo, Sao Paulo, Brazil., Rocha LA; Departamento de Genética e Biologia Evolutiva do Instituto de Biociências, Universidade de São Paulo, Sao Paulo, Brazil., Linnenkamp BDW; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Castro MAA; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Bartholdi D; Department of Human Genetics, University of Bern, Bern, Switzerland., Schaller A; Department of Human Genetics, University of Bern, Bern, Switzerland., Leeb T; Institute of Genetics, University of Bern, Bern, Switzerland., Kelmann S; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Utagawa CY; Centro Universitário de Volta Redonda, Volta Redonda, Brazil., Steiner CE; Hospital das Clínicas, UNICAMP, Campinas, Brazil., Steinmetz L; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Honjo RS; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Kim CA; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil., Wang L; 9Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA., Abourjaili-Bilodeau R; University of Montreal, Montreal, Québec, Canada., Campeau PM; CHU Sainte-Justine Research Center, University of Montreal, Montreal, Québec, Canada., Warman M; Department of Orthopedics, Boston Children's Hospital, Boston, Massachusetts, USA.; Genetics, Harvard Medical School, Boston, Massachusetts, USA., Passos-Bueno MR; Departamento de Genética e Biologia Evolutiva do Instituto de Biociências, Universidade de São Paulo, Sao Paulo, Brazil., Hoch NC; Departamento de Bioquímica do Instituto de Química, Universidade de Sao Paulo, Sao Paulo, Brazil., Bertola DR; Departamento de Genética e Biologia Evolutiva do Instituto de Biociências, Universidade de São Paulo, Sao Paulo, Brazil debora.bertola@usp.br.; Departamento de Pediatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil.
Publikováno v: Journal of medical genetics [J Med Genet] 2023 Nov; Vol. 60 (11), pp. 1127-1132. Date of Electronic Publication: 2023 Apr 13.
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10
Akademický článek
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.
Autor: Serrano-Benitez A; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; The Wellcome and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK., Wells SE; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK., Drummond-Clarke L; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK., Russo LC; Departament of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Thomas JC; The Wellcome and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK., Leal GA; Departament of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Farrow M; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Edgerton JM; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Balasubramanian S; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Yang M; CECAD Research Center, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Frezza C; CECAD Research Center, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Gautam A; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK., Brazina J; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK., Burdova K; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK., Hoch NC; Departament of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Jackson SP; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.; The Wellcome and Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK., Caldecott KW; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, UK.
Publikováno v: The EMBO journal [EMBO J] 2023 Sep 18; Vol. 42 (18), pp. e113190. Date of Electronic Publication: 2023 Jul 26.
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