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Publikováno v:
Tetrahedron Letters. 36:1359-1362
Autor:
I. Najera, Sophie Le Pogam, Graham Maile, Hobbs Christopher John, JH Merrett, Steven Swallow, Carl Laxton, Julie Hang, Rene Devos, Stewart J. Baker, Han Ma, Keshab Sarma, Julian Symons, Klaus Klumpp, David Bernard Smith, Vincent Leveque, David R. Vesey, Peter Blomgren, Mark D. Smith, Arkadius Pichota, Joseph Armstrong Martin, W.R. Jiang, Caroline Granycome, Nick Cammack
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(9)
A series of 4'-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4'-azidocytidine, R1479) wi