Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects.

Autor: Wang Y; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Buck A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Piel B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Zerefa L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Murugan N; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Coherd CD; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Miklosi AG; ONI (Oxford Nanoimaging Ltd.), Oxford, UK., Johal H; ONI (Oxford Nanoimaging Ltd.), Oxford, UK., Bastos RN; ONI (Oxford Nanoimaging Ltd.), Oxford, UK., Huang K; Molecular Imaging Core, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Ficial M; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA., Laimon YN; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA., Signoretti S; Harvard Medical School, Boston, MA, 02115, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Zhong Z; LUMICKS, Waltham, MA, 02453, USA., Hoang SM; LUMICKS, Waltham, MA, 02453, USA., Kastrunes GM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Grimaud M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Fayed A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Yuan HC; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Thai T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Ivanova EV; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Belfer Center of Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Paweletz CP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Belfer Center of Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Wu MR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Choueiri TK; Harvard Medical School, Boston, MA, 02115, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Wee JO; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Freeman GJ; Harvard Medical School, Boston, MA, 02115, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Barbie DA; Harvard Medical School, Boston, MA, 02115, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Belfer Center of Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, 02215, USA., Marasco WA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. wayne_marasco@dfci.harvard.edu.; Harvard Medical School, Boston, MA, 02115, USA. wayne_marasco@dfci.harvard.edu.

Publikováno v: Molecular cancer [Mol Cancer] 2024 Mar 16; Vol. 23 (1), pp. 56. Date of Electronic Publication: 2024 Mar 16.

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.

Autor: Hoang SM; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Kaminski N; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Bhargava R; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Barroso-González J; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., García-Expósito L; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Roncaioli JL; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Wondisford AR; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Wallace CT; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Watkins SC; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., James DI; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK., Waddell ID; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK., Ogilvie D; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK., Smith KM; Drug Discovery Unit, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, Macclesfield, UK., da Veiga Leprevost F; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Mellacharevu D; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Nesvizhskii AI; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Li J; Department of Pharmacology and the Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Ray-Gallet D; Institut Curie, PSL Research University, CNRS, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée, Ligue contre le Cancer, Paris, France., Sobol RW; Department of Pharmacology and the Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA., Almouzni G; Institut Curie, PSL Research University, CNRS, Sorbonne Université, Nuclear Dynamics Unit, Equipe Labellisée, Ligue contre le Cancer, Paris, France., O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. osullivanr@upmc.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Dec; Vol. 27 (12), pp. 1152-1164. Date of Electronic Publication: 2020 Oct 12.

Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.

Autor: Hoang SM; Department of Pharmacology and Chemical Biology, Hillman Cancer Center, University of Pittsburgh School of Medicine (UPMC), Pittsburgh, PA, USA., O'Sullivan RJ; Department of Pharmacology and Chemical Biology, Hillman Cancer Center, University of Pittsburgh School of Medicine (UPMC), Pittsburgh, PA, USA. Electronic address: osullivanr@upmc.edu.

Publikováno v: Trends in cancer [Trends Cancer] 2020 Mar; Vol. 6 (3), pp. 247-260. Date of Electronic Publication: 2020 Jan 23.

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.

Autor: Barroso-González J; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., García-Expósito L; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Hoang SM; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Roncaioli JL; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Ghosh A; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Wallace CT; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., de Vitis M; Department of Science, University of Rome 'ROMA TRE', 00146 Rome, Italy., Modesti M; Cancer Research Center of Marseille, CNRS UMR7258, Inserm UMR1068, Aix Marseille Université U105; Institut Paoli Calmettes, 27 Boulevard Lei Roure CS30059, 13273 Marseille, Cedex 09, France., Bernstein KA; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Sarkar SN; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., Watkins SC; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA., O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: osullivanr@upmc.edu.

Publikováno v: Molecular cell [Mol Cell] 2019 Oct 03; Vol. 76 (1), pp. 11-26.e7. Date of Electronic Publication: 2019 Aug 07.

A semiconductor radiation imaging pixel detector for space radiation dosimetry.

Autor: Kroupa M; Lockheed Martin, Houston, TX, USA. Electronic address: martin.kroupa@nasa.gov., Bahadori A; Space Radiation Analysis Group, National Aeronautics and Space Administration, Johnson Space Center, Houston, TX, USA., Campbell-Ricketts T; University of Houston, Houston, TX, USA., Empl A; University of Houston, Houston, TX, USA., Hoang SM; University of Houston, Houston, TX, USA., Idarraga-Munoz J; University of Houston, Houston, TX, USA., Rios R; Lockheed Martin, Houston, TX, USA., Semones E; Space Radiation Analysis Group, National Aeronautics and Space Administration, Johnson Space Center, Houston, TX, USA., Stoffle N; Lockheed Martin, Houston, TX, USA., Tlustos L; University of Houston, Houston, TX, USA., Turecek D; University of Houston, Houston, TX, USA; Institute of Experimental and Applied Physics, Czech Technical University in Prague, Prague, Czech Republic., Pinsky L; University of Houston, Houston, TX, USA.

Publikováno v: Life sciences in space research [Life Sci Space Res (Amst)] 2015 Jul; Vol. 6, pp. 69-78. Date of Electronic Publication: 2015 Jul 03.