Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hoang Hirschberg"'
Autor:
Heleen Kraan, Gijsbert G.P. van de Wijdeven, Hoang Hirschberg, Jean-Pierre Amorij, Gideon F.A. Kersten
Publikováno v:
Journal of Controlled Release. 147:211-217
An alternative vaccine delivery system for needle injections is the Bioneedle. Hepatitis B surface antigen (HBsAg) was formulated with Bioneedles. Three formulations were used: plain antigen, HBsAg adjuvated with aluminum hydroxide and HBsAg with LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f8881a54c9b5135a4bcc2d60a999d0
https://doi.org/10.1016/j.jconrel.2010.06.028
https://doi.org/10.1016/j.jconrel.2010.06.028
Autor:
Germie P. J. M. van den Dobbelsteen, Gideon F.A. Kersten, Annemarie B. Kelder, Gijsbert G.P. van de Wijdeven, Hoang Hirschberg
Publikováno v:
Vaccine. 26:2389-2397
Bioneedles are small hollow mini implants fabricated from biodegradable polymers which can be filled with antigen. Bioneedles can be used for vaccination without syringes and needles. Formulations have been prepared containing tetanus toxoid with and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b927b2fd5c58d78a2cc8b7fc4b4fdca6
https://doi.org/10.1016/j.vaccine.2008.02.067
https://doi.org/10.1016/j.vaccine.2008.02.067
Autor:
Hoang Hirschberg, Joke A. Bouwstra, Wim Jiskoot, Maytal Bivas-Benita, Zhi Ding, Gideon F.A. Kersten
Publikováno v:
Journal of Drug Targeting. 16:555-563
The objective was to develop surfactant-based vesicle formulations containing diphtheria toxoid (DT) for transcutaneous immunization. Formulation variables were molar ratio of the surfactants (sucrose-laurate ester, octaoxyethylene-laurate ester, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f3105df1939b297ec6d428fab38249
https://doi.org/10.1080/10611860802228673
https://doi.org/10.1080/10611860802228673
Autor:
Anne H. de Boer, Hubert C. Pellikaan, Gideon F.A. Kersten, Maryam Amidi, Daan J.A. Crommelin, Hoang Hirschberg, Wim E. Hennink, Wim Jiskoot
Publikováno v:
Vaccine, 25(37-38), 6818-6829. ELSEVIER SCI LTD
this study, the potential of N-Trimethyl chitosan (TMC, degree of quaternization 50%) and dextran microparticles for pulmonary delivery of diphtheria toxoid (DT) was investigated. The antigen-containing microparticles were prepared by drying of an aq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0f17bd4b6076b55778607c9d823c7e
https://hdl.handle.net/11370/6d350612-f68b-4e43-819a-905d0b424aa9
https://hdl.handle.net/11370/6d350612-f68b-4e43-819a-905d0b424aa9
Autor:
Gideon F.A. Kersten, Hoang Hirschberg
Publikováno v:
Expert Review of Vaccines. 3:453-462
Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773eb17d19935bdf4206384a3a910160
https://doi.org/10.1586/14760584.3.4.453
https://doi.org/10.1586/14760584.3.4.453
Publikováno v:
European Journal of Pharmaceutical Sciences, 71, 112-122
Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis. For this purpose many delivery techniques are being developed. In vivo immunogenicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f13cd98eb7cddd0f2223af7d7bf8a2
https://pubmed.ncbi.nlm.nih.gov/25686596
https://pubmed.ncbi.nlm.nih.gov/25686596
Autor:
Jean-Pierre Amorij, Sandra J.A. van Kuijk, Wim Jiskoot, Gideon F.A. Kersten, Joke A. Bouwstra, Hoang Hirschberg, Jessica Loch
Publikováno v:
European Journal of Pharmaceutical Sciences, 46(1-2), 1-7
In the search for an optimal approach for the transcutaneous immunization (TCI) of hepatitis B surface antigen (HBsAg), two vesicle formulations, L595 vesicles (composed of sucrose-laurate ester and octaoxyethylene-laurate ester) and sPC vesicles (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099b739754d51ddf15b21199b9a72de0
https://doi.org/10.1016/j.ejps.2012.01.013
https://doi.org/10.1016/j.ejps.2012.01.013
Autor:
Hoang Hirschberg, Gideon F.A. Kersten
Publikováno v:
Expert opinion on drug delivery. 4(5)
The need for minimally invasive delivery methods is urgent. As the number of registered vaccines increases, so does the number of injections. The use of sharps can be unsafe and needle immunisation is less suitable for mass immunisations during emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45c07641ba587474d3dd6bd4434f73a
https://pubmed.ncbi.nlm.nih.gov/17880271
https://pubmed.ncbi.nlm.nih.gov/17880271