Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hoang Dai Tran"'
Publikováno v:
Stem Cell Research, Vol 73, Iss , Pp 103264- (2023)
Transmembrane protein 119 (TMEM119) is a recently identified microglia marker that is not expressed by other immune cells. Using CRISPR/Cas9 technology, we introduced enhanced green fluorescence protein (EGFP), into the H9 WA-09 human embryonic stem
Externí odkaz:
https://doaj.org/article/a173bc3f1ef74168b23a955e9c434126
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108138- (2023)
Summary: SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants. While in vitro studies
Externí odkaz:
https://doaj.org/article/fdc80743068a4226a9920660a68ec3ad
Autor:
Min-Kyoung Shin, Jin Seok Bang, Jeoung Eun Lee, Hoang-Dai Tran, Genehong Park, Dong Ryul Lee, Junghyun Jo
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5108 (2022)
In vitro organoids derived from human pluripotent stem cells (hPSCs) have been developed as essential tools to study the underlying mechanisms of human development and diseases owing to their structural and physiological similarity to corresponding o
Externí odkaz:
https://doaj.org/article/8014c107ffa2407187333c409d36e1f1
Autor:
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1942-1953 (2016)
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathogenesis o
Externí odkaz:
https://doaj.org/article/091f2fb94fb34db09bbe7c3f12c0d72b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Melvin M. Evers, Hoang-Dai Tran, Ioannis Zalachoras, Barry A. Pepers, Onno C. Meijer, Johan T. den Dunnen, Gert-Jan B. van Ommen, Annemieke Aartsma-Rus, Willeke M.C. van Roon-Mom
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 49-56 (2013)
Spinocerebellar ataxia type 3 is caused by a polyglutamine expansion in the ataxin-3 protein, resulting in gain of toxic function of the mutant protein. The expanded glutamine stretch in the protein is the result of a CAG triplet repeat expansion in
Externí odkaz:
https://doaj.org/article/ce973f13299e482a8c9099a6f53954e9
Autor:
Hoang-Dai Tran, Min-Kyoung Shin, Charlotte Denman, Run-Run Han, Bernd Kuhn, Gordon Arbuthnott, Junghyun Jo
Publikováno v:
SSRN Electronic Journal.
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Autor:
Paul M. Yen, Brijesh K. Singh, Eyleen L. K. Goh, Danlei Wang, Jin Zhou, Dongrui Ma, Jinyan Zhang, Yi Zhao, Eng-King Tan, Dongliang Ma, Hoang-Dai Tran, Alfred Xuyang Sun, Wei Zhou
Publikováno v:
Human Molecular Genetics
Coiled-coil-helix-coiled-coil-helix domain containing protein 2 (CHCHD2) mutations were linked with autosomal dominant Parkinson’s disease (PD) and recently, Alzheimer’s disease/frontotemporal dementia. In the current study, we generated isogenic