Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.

Autor: Maharry SE; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Walker CJ; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Liyanarachchi S; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Mehta S; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Patel M; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Bainazar MA; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Huang X; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Lankenau MA; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Hoag KW; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Ranganathan P; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Garzon R; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Blachly JS; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Guttridge DC; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Bloomfield CD; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., de la Chapelle A; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Eisfeld AK; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio. ann-kathrin.eisfeld@osumc.edu.

Publikováno v: Cancer discovery [Cancer Discov] 2016 Sep; Vol. 6 (9), pp. 1036-51. Date of Electronic Publication: 2016 Jun 27.

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia.

Autor: Kämpjärvi K; Department of Medical Genetics and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Järvinen TM; Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Heikkinen T; Department of Medical Genetics and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Ruppert AS; Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Senter L; Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Hoag KW; Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Dufva O; Department of Medical Genetics and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland., Kontro M; Hematology Research Unit Helsinki, Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland., Rassenti L; Moores University of California-San Diego Cancer Center, University of California San Diego, CA, USA., Hertlein E; Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Kipps TJ; Moores University of California-San Diego Cancer Center, University of California San Diego, CA, USA., Porkka K; Hematology Research Unit Helsinki, Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland., Byrd JC; Department of Internal Medicine, Division of Hematology, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., de la Chapelle A; Department of Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center at The Ohio State University, Columbus, OH, USA., Vahteristo P; Department of Medical Genetics and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

Publikováno v: Oncotarget [Oncotarget] 2015 Jan 30; Vol. 6 (3), pp. 1884-8.

NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.

Autor: Eisfeld AK; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210., Schwind S, Hoag KW, Walker CJ, Liyanarachchi S, Patel R, Huang X, Markowitz J, Duan W, Otterson GA, Carson WE 3rd, Marcucci G, Bloomfield CD, de la Chapelle A

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Mar 18; Vol. 111 (11), pp. 4179-84. Date of Electronic Publication: 2014 Feb 28.