Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ho-Yin Lo"'
Autor:
Yin Quan Zhao, Hong Ri Jin, Daeho Kim, Sung Han Jung, Sheng Liu, Jun Wan, Ho‐Yin Lo, Xue Qi Fu, Quan Wang, Chunhai Hao, Anita C. Bellail
Publikováno v:
Molecular Carcinogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5ff5594bd58ef035af0c156c1cd1f22
https://doi.org/10.1002/mc.23560
https://doi.org/10.1002/mc.23560
Autor:
Anita C. Bellail, Chunhai Hao, Chafiq Hamdouchi, Wen Jiang, Anantha Shekhar, Hong Ri Jin, Manali Ghosh, Ho Yin Lo, Ryan K. Higgins, Maximilian Blanck, Amber L. Mosley, Aruna B. Wijeratne, Jing Li, Daeho Kim, Benedict C. S. Cross, Sung Han Jung, Paula M. Hauck, Yin Quan Zhao, Carlos le Sage
Publikováno v:
Sci Transl Med
Discovery of small-molecule degraders that activate ubiquitin ligase–mediated ubiquitination and degradation of targeted oncoproteins in cancer cells has been an elusive therapeutic strategy. Here, we report a cancer cell–based drug screen of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddb24189427eb135e924d78b3a87ab
https://doi.org/10.1126/scitranslmed.abh1486
https://doi.org/10.1126/scitranslmed.abh1486
Autor:
Raymond Chuen-Chung Chang, Hoi-Yan Yeung, Yuen Shan Ho, Novem Ching-Yee Lam, Ho-Yin Lo, Chun-Fong Yuen, Wai-Kiu Li
Publikováno v:
Brain Research. 1719:274-284
Background Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder which is characterized by altered bowel habits. A growing number of studies investigate the association between IBS and cognitive impairments. Current studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84577bd80166c3e5ae5e69ab8ed1f5a5
https://doi.org/10.1016/j.brainres.2019.05.036
https://doi.org/10.1016/j.brainres.2019.05.036
Publikováno v:
Journal of Moral Education. 49:177-193
This article examines relationships between children and youths’ judgments and their justifications of truth telling and verbal deception, in situational and cultural contexts. Han Chinese, Euro-Ca...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c95da800f55ce49eef5f45445f869b
https://doi.org/10.1080/03057240.2018.1563881
https://doi.org/10.1080/03057240.2018.1563881
Publikováno v:
Fuel. 289:119782
Pyrolysis of brown grease to hydrocarbon products was performed in a pressure reactor. Compared to our previous work at atmospheric pressure, higher reaction temperatures could be achieved. These resulted in shorter reaction times, reduced formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b2a9da0770296ff4e942310a95559e
https://doi.org/10.1016/j.fuel.2020.119782
https://doi.org/10.1016/j.fuel.2020.119782
Autor:
Adam Flegg, Tina Morwick, Ho Yin Lo, Todd Bosanac, Weimin Liu, Valentina Berger, Steven Kerr, Stéphane De Lombaert, Paige Erin Mahaney, Ralph Binetti, John Broadwater, Spencer Napier, Alessandra Bartolozzi, Lifen Wu, Hidenori Takahashi, Asitha Abeywardane, Heather Tye, Tazmeen Fadra-Khan, John D. Huber, Adrian Kotey, Ming-Hong Hao, Dines Jonathon Alan, Anil Kumar Padyana, Alan Olague, Michael Garrigou, David S. Thomson, J. Matthew Hutzler, Pui Leng Loke, Renee Zindell, Edward Pack, Zhidong Chen, Rebecca Crux, Thomas Simpson, Rajvee Dave, Doris Riether
Publikováno v:
Journal of Medicinal Chemistry. 58:1669-1690
The synthesis, structure–activity relationship (SAR), and evolution of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are described. The use of structure-guided drug design techniques provided compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec30afc1732226a8a2acaaba6be03b4
https://doi.org/10.1021/jm501185j
https://doi.org/10.1021/jm501185j
Publikováno v:
Journal of Cross-Cultural Psychology. 45:1196-1214
Verbal deception may be considered morally reprehensible or acceptable depending on culturally relevant contextual factors and ethical perspectives. In the current study, Euro-Canadian ( n = 180) and Han Chinese ( n = 180) children ages 8 to 16 were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf90ec84b4a5813d6c36d58cb8703e84
https://doi.org/10.1177/0022022114535485
https://doi.org/10.1177/0022022114535485
Autor:
Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
A new class of chymase inhibitor featuring a benzimidazolone core with an acid side chain and a P1 hydrophobic moiety is described. Incubation of the lead compound with GSH resulted in the formation of a GSH conjugate on the benzothiophene P1 moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df6a496eb118478cab46c6fde2569f9
https://doi.org/10.1016/j.bmcl.2011.05.126
https://doi.org/10.1016/j.bmcl.2011.05.126
Autor:
Alison Kukulka, Ho Yin Lo, Roman Wolfgang Fleck, Raj Betageri, Mary Ann Hoermann, Usha R. Patel, Stéphane De Lombaert, Alisa K. Kabcenell, Richard H. Ingraham, Rajiv Sharma, Kirrane Thomas M, John R. Proudfoot, Neil A. Farrow, Chuk Chui Man
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6379-6383
A novel series of pyrazole sEH inhibitors is reported. Lead optimization efforts to replace the aniline core are also described. In particular, 2-pyridine, 3-pyridine and pyridazine analogs are potent sEH inhibitors with favorable CYP3A4 inhibitory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b621596bd901063820e3338d03b29798
https://doi.org/10.1016/j.bmcl.2010.09.095
https://doi.org/10.1016/j.bmcl.2010.09.095
Autor:
Andre White, Joseph R. Woska, Ho Yin Lo, Josephine King, John P. Wolak, Mohammed A. Kashem, Jörg Bentzien, Hnin Hnin Khine, Roman Wolfgang Fleck, Steven S. Pullen, Chuk Chui Man, Gregory P. Roth, Hidenori Takahashi
Publikováno v:
Tetrahedron Letters. 49:7337-7340
Based on information from molecular modeling, a series of 2-aminobenzimidazoles with pyrrole moieties were designed and synthesized as ITK antagonists. Results showed that a significant improvement of intrinsic and cell-based potency was achieved. X-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bf5c55c7c49b4297d1b889eb3578745
https://doi.org/10.1016/j.tetlet.2008.10.057
https://doi.org/10.1016/j.tetlet.2008.10.057