Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ho-Shen Lin"'
Autor:
Michael Enrico Richett, Ashraff A. Rampersaud, Robert Alan Gadski, Patricia S. Foxworthy, Anthony J Gardner, Patrick I. Eacho, Richard Waltz Harper, Ho-Shen Lin, Mcclure Don B, Lisa Selsam Beavers
Publikováno v:
Steroids. 64:217-227
4Alpha-(2-propenyl)-5alpha-cholestan-3alpha-ol (LY295427) was previously identified from a Chinese hamster ovary (CHO) cell-based low density lipoprotein receptor/luciferase (LDLR/Luc) assay to be a potent transcriptional activator of the LDL recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5614a8ed3bf5358518b533569e970616
https://doi.org/10.1016/s0039-128x(98)00083-x
https://doi.org/10.1016/s0039-128x(98)00083-x
Autor:
Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:775-780
Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe7d35a63ca810bf308f9e6a8bf352
https://doi.org/10.1016/s0960-894x(99)00074-8
https://doi.org/10.1016/s0960-894x(99)00074-8
Autor:
Ashraff A. Rampersaud, Mcclure Don B, Ho-Shen Lin, Lisa Selsam Beavers, Michael Enrico Richett, Robert Alan Gadski
Publikováno v:
Steroids. 63:202-207
4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up-regulator and had demonstrated to be an effective agent in lowering plasma cholesterol levels in hypercholesterolemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37cc5e6f2135bb109a7387a34fdef80d
https://doi.org/10.1016/s0039-128x(98)00004-x
https://doi.org/10.1016/s0039-128x(98)00004-x
Autor:
David A. Preston, Ashraff A. Rampersaud, Ernie C. Y. Wu, J. E. Flokowitsch, William E. Alborn, Ho-Shen Lin
Publikováno v:
Journal of the Chinese Chemical Society. 42:833-845
The preparation and biological evaluation of 7β-[[2-(phenyl)thiazol-4-yl]acetamido]cephalosporins and 7β-[[(2-(pyridin-2-yl)thiazol-4-yl]acetamido]cephalosporins, 9a-o, substituted at the 3-position with acetyloxymethyl, chlorine, hydrogen, and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc2eb274b04cb91603513260f6b7a43
https://doi.org/10.1002/jccs.199500113
https://doi.org/10.1002/jccs.199500113
Autor:
Ashraff A. Rampersaud, Archer Ra, T F Bumol, Raymond F. Kauffman, L S Beavers, Ho-Shen Lin, Pawlak Jm, William R. Bensch, Schmidt Rj, L D Apelgren
Publikováno v:
Journal of Medicinal Chemistry. 38:277-288
A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing the transcription of LDL receptor promoter in the presence of 25-hydroxycholesterol. The eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91c7a660d1143ede3426f54cb972acc
https://doi.org/10.1021/jm00002a010
https://doi.org/10.1021/jm00002a010
Autor:
Ho-Shen Lin, Leo A. Paquette
Publikováno v:
Synthetic Communications. 24:2503-2506
A convenient procedure for the quantitative assay of alkyl, aryl, and vinyl Grignard reagent concentrations is described. Through the combined use of menthol and 1,10-phenanthroline in dry tetrahydrofuran solution, vivid violet or burgundy end points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18091c3c803f80f62cdb187cc7b8a9a0
https://doi.org/10.1080/00397919408010560
https://doi.org/10.1080/00397919408010560
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f3297db22a4a50d3200c60fbe325223
https://doi.org/10.1002/chin.199112340
https://doi.org/10.1002/chin.199112340
Autor:
Donald B. Boyd, Ho Shen Lin, Ashraff A. Rampersaud, Karen M. Zimmerman, Mitchell I. Steinberg
Publikováno v:
Journal of Medicinal Chemistry. 35:2658-2667
A series of nonpeptide angiotensin II receptor antagonists was synthesized and tested in vitro to investigate requirements for recognition by and binding to AT1 receptors. Compared to a known series of N-(biphenylylmethyl)imidazoles, including losart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8776dd537fc142e0b2eeb9ca447fec70
https://doi.org/10.1021/jm00092a017
https://doi.org/10.1021/jm00092a017
Publikováno v:
Journal of Computational Chemistry. 12:635-644
Using computer model building, the three-dimensional structure of an enzyme from Streptomyces R61 that is inhibited by s-lactam antibiotics has been constructed starting from incomplete X-ray crystallographic data for this 37.4 kDa protein. The so-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fdd2e1c6865a56cc6eed3ee64dc6960
https://doi.org/10.1002/jcc.540120514
https://doi.org/10.1002/jcc.540120514
Publikováno v:
Journal of the American Chemical Society. 112:9284-9292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da838cacc1fbd3ad8f130c75dbe1f47
https://doi.org/10.1021/ja00181a034
https://doi.org/10.1021/ja00181a034