Výsledky vyhledávání - "Ho-Seok Kwon"

Occupational radiation exposure in femoral artery approach is higher than radial artery approach during coronary angiography or percutaneous coronary intervention

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports

Medical radiation exposure is a significant concern for interventional cardiologists (IC). This study was aimed at estimating the radiation exposure of IC operators and assistants in real clinical practice. The radiation exposure of the operator and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06d41f4b374a4480ea691f80de06b6f
https://doi.org/10.1038/s41598-020-62794-2

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Abstract 1295: SJP1901, a small molecule inhibitor targeting hippo pathway by directly inhibiting TEAD palmitoylation in hippo pathway-dependent cancer

Autor: Jihyun Um, Moon Jung Back, Jeongmin Lee, Hyun Tae Kim, Shin You-Keun, Yongbin Park, Hwan Jung Lim, Janghyun Lee, Li-Kyung Kim, Sujin Park, Jae-Woong Lee, Seongjun Park, Kwangwoo Hwang, Jooyoung Hyun, Dohyeong Lee, Min-Hyo Ki, Ho-Seok Kwon, Hei Cheul Jeung

Publikováno v: Cancer Research. 81:1295-1295

The hippo pathway is a critical transcriptional regulator of cell growth, proliferation, and migration in cancer, furthermore,YAP-TEAD complexes act as a major role in the pathway. S-palmitoylation of cysteine residues in TEAD proteins is required fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3364192ae1fd0937464debe616490991
https://doi.org/10.1158/1538-7445.am2021-1295

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Abstract 1742: Dual inhibitor of immunokinase and pan-RAF for the treatment of KRAS-mutated cancers

Autor: Yongbin Park, Hee Jong Shin, Soon Kil Ahn, Min-Hyo Ki, Ho-Seok Kwon, Sungpyo Hong

Publikováno v: Cancer Research. 78:1742-1742

Tumor-associated macrophages (TAMs) represent most of the white blood cell population in solid tumors. TAMs usually display an M2-like phenotype due to signals from the tumor microenvironment, such as IL-10, VEGFA and CSF-1/M-CSF. These anti-inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8703003958c26c860daec5028b9a9851
https://doi.org/10.1158/1538-7445.am2018-1742

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The Structure-Activity Relationships of 2,4(1H,3H)-pyrimidinedione Derivatives as potent HIV type 1 and type 2 inhibitors

Autor: Chung Sun-Gan, Tracy L. Hartman, Ho Seok Kwon, Robert W. Buckheit, Eui Hwan Cho, Sun Hwan Lee, Lee Jae-Woong, Kang Dong-Wook, Karen M. Watson

Publikováno v: Antiviral Chemistry and Chemotherapy. 18:259-275

Since the discovery of the 2,4 (1 H,3 H)-pyrimidinediones as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase (RT) this class of compounds has yielded a number of N-1 acyclic substituted pyrimidinediones with substantial antiviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a8d9f520a731bc3c616d25dceddc0b
https://doi.org/10.1177/095632020701800502

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Abstract 5162: Development of a dual inhibitor of pan-RAF and angiogenesis for the treatment of metastatic colorectal cancer with mutant K-RAS

Autor: Sungpyo Hong, Younghoon Choi, Ho-Seok Kwon, Yong Bin Park, Min-Hyo Ki, Hee Jong Shin, Michael Lee, Soon Kil Ahn

Publikováno v: Cancer Research. 77:5162-5162

Colorectal cancer(CRC) is one of the most common cancers and a leading cause of cancer-related death in the western world. K-RAS mutation has been reported in 40% of colorectal cancer patients. KRAS mutations have been significantly associated with l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10a91a8e0535274b2b9da2af1afaee49
https://doi.org/10.1158/1538-7445.am2017-5162

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PALLADIUM-CATALYZED CROSS-COUPLING OF ORGANOTELLURIUM COMPOUNDS WITH HYPERVALENT IODONIUM SALTS

Autor: Suk-Ku Kang, Sang-Woo Lee, Moon-Sik Kim, Ho-Seok Kwon

Publikováno v: Synthetic Communications. 31:1721-1725

The palladium-catalyzed cross-coupling of hypervalent iodonium salts with organotellurium dichloride was achieved with PdCl2 (10 mol %) in the presence of NaOMe (3 equiv) in CH3CN/MeOH at room temperature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f61a5ae370d257e5fc60ff5db8872e7b
https://doi.org/10.1081/scc-100103992

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Abstract 3782: Development of a dual inhibitor of pan-RAF and VEGFR2 for the treatment of metastatic colorectal cancer with mutant K-RAS

Autor: Wonyoung Kim, Ho-Seok Kwon, Yong Bin Park, Sungpyo Hong, Young-Il Choi, Jihye Choi, Soon Kil Ahn, Min-Hyo Ki, Hee Jong Shin, Michael Lee

Publikováno v: Cancer Research. 76:3782-3782

Signal transduction in the RAS-RAF-MEK-ERK (MAPK) pathway plays a key role in cell survival, growth and proliferation. The pathway is controlled by extracellular signals through receptor tyrosine kinases (RTK) and is activated by oncogenic mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c398ed55ed865c36f98282a28e3b6c9
https://doi.org/10.1158/1538-7445.am2016-3782

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Anti-angiogenic and anti-tumor apoptotic activities of a topoisomerase II inhibiting agent SJ-8026

Autor: Chung Sun-Gan, Yung-Jin Kim, Eui-Yeun Yi, Dong-Wook Kang, Park Si-Kyung, Sun-Hwan Lee, Cho Eui-Hwan, Ho-Seok Kwon, Joo Jeong-Ho, Eun-Joo Jeong

Publikováno v: International journal of oncology. 26(6)

A new piperazine derivative, SJ-8026, is a synthetic anti-cancer agent which exhibits topoisomerase II-inhibiting activities. In this study, we investigated the possibility that this compound inhibits angiogenesis and induces tumor-cell apoptosis usi

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https://pubmed.ncbi.nlm.nih.gov/15870877

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Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative

Autor: Sun-Hwan Lee, Park Si-Kyung, Ho-Seok Kwon, Eui-Yeun Yi, Eun-Joo Jeong, Dong-Wook Kang, Mi-Sook Lee, Chung Sun-Gan, Hyun Seok Song, Joo Jeong-Ho, Yung-Jin Kim, Cho Eui-Hwan

Publikováno v: International journal of oncology. 25(2)

A new piperazine derivative, SJ-8002, is a synthetic anti-cancer agent which exhibits microtubule-inhibiting activities. In this study, we investigated the possibility that this compound inhibits angiogenesis and induces tumor-cell apoptosis using bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2527a22d43e4742a0860cb2200bbf2f4
https://pubmed.ncbi.nlm.nih.gov/15254733

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