Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ho-Jun Jeon"'
Autor:
Ho jun Jeon, Namcheol Kim, Lee Seung-Woo, Jin Kyun Park, Yong Suk Lee, Seong Kyu Park, Jaewhan Kim
Publikováno v:
Nuclear Engineering and Technology, Vol 51, Iss 5, Pp 1297-1306 (2019)
Probabilistic safety assessments (PSA) have been used for several decades to visualize the risk level of commercial nuclear power plants (NPPs). Since the role of a human reliability analysis (HRA) is to provide human error probabilities for safety c
Autor:
Mi-Ae Yoo, Ho-Jun Jeon, Jung-Hoon Pyo, Kyu Heo, Young-Shin Kim, Joung-Sun Park, Masamitsu Yamaguchi, Joong-Gook Kim
Publikováno v:
Mechanisms of Ageing and Development. 173:50-60
Chromatin change is one of the crucial causes of aging. Specifically, maintenance of heterochromatin stability is critical for cellular integrity, and its loss induces genomic instability and cellular aging. However, the causes and effects of heteroc
Publikováno v:
Oncotarget
The intestine is a high cellular turnover tissue largely dependent on the regenerative function of stem cell throughout life, and a signaling center for the health and viability of organisms. Therefore, better understanding of the mechanisms underlyi
Publikováno v:
Aging. 10:322-338
Stem cell dysfunction is closely linked to tissue and organismal aging and age-related diseases, and heavily influenced by the niche cells' environment. The DNA damage response (DDR) is a key pathway for tissue degeneration and organismal aging; howe
Publikováno v:
Biochemical and Biophysical Research Communications. 498:18-24
Age-related changes of adult stem cell are crucial for tissue aging and age-related diseases. Thus, clarifying mechanisms to prevent adult stem cell aging is indispensable for healthy aging. Metformin, a drug for type 2 diabetes, has been highlighted
Autor:
Young-Shin Kim, Mi-Ae Yoo, Jung Hoon Pyo, Joung Sun Park, Robert Arking, Ho-Jun Jeon, Hyun Jin Na
Publikováno v:
Mechanisms of Ageing and Development. 149:8-18
We delineated the mechanism regulating the inhibition of centrosome amplification by metformin in Drosophila intestinal stem cells (ISCs). Age-related changes in tissue-resident stem cells may be closely associated with tissue aging and age-related d
Publikováno v:
Aging (Albany NY)
The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related facto
Autor:
Eun-Bin, Bae, Keun-Ho, Park, Jin-Hyung, Shim, Ho-Yun, Chung, Jae-Won, Choi, Jin-Ju, Lee, Chang-Hwan, Kim, Ho-Jun, Jeon, Seong-Soo, Kang, Jung-Bo, Huh
Publikováno v:
BioMed Research International
This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic pro
Publikováno v:
Aging (Albany NY)
Stem cell dysfunction is closely linked to tissue and organismal aging and age-related diseases, and heavily influenced by the niche cells’ environment. The DNA damage response (DDR) is a key pathway for tissue degeneration and organismal aging; ho
Autor:
Hyun Jin Na, Young-Shin Kim, Jung Hoon Pyo, Ho-Jun Jeon, Joung Sun Park, Robert Arking, Mi-Ae Yoo
Publikováno v:
Biochemical and Biophysical Research Communications. 450(2):961-965
Age-related changes in long-lived tissue-resident stem cells may be tightly linked to aging and age-related diseases such as cancer. Centrosomes play key roles in cell proliferation, differentiation and migration. Supernumerary centrosomes are known