Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ho Wa Lau"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103123- (2024)
Summary: Here, we present a protocol to perform CRISPR-Cas9 genome editing in human resting primary natural killer (NK) and NK-92 cells. We describe steps for guide RNA selection, ribonucleoprotein (RNP) complex formation, delivery via Nucleofection,
Externí odkaz:
https://doaj.org/article/34be51c4937340bc921941d7ca0f8a8c
Autor:
Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gasparini, Pierre Montay-Gruel, Maxim Le Compte, Eva Lion, Filip Lardon, Steven Van Laere, Vasiliki Siozopoulou, Diana Campillo-Davo, Jorrit De Waele, Patrick Pauwels, Julie Jacobs, Evelien Smits, Jonas R. M. Van Audenaerde
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background It remains challenging to obtain positive outcomes with chimeric antigen receptor (CAR)-engineered cell therapies in solid malignancies, like colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). A major obstacle is
Externí odkaz:
https://doaj.org/article/8761eb0063d942beb968b458b3b522ca
Autor:
Tal Flieswasser, Astrid Van den Eynde, Laurie Freire Boullosa, Jöran Melis, Christophe Hermans, Céline Merlin, Ho Wa Lau, Jonas Van Audenaerde, Filip Lardon, Evelien Smits, Patrick Pauwels, Julie Jacobs
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTDespite the recent emergence of immune checkpoint inhibitors, clinical outcomes of metastatic NSCLC patients remain poor, pointing out the unmet need to develop novel therapies to enhance the anti-tumor immune response in NSCLC. In this regar
Externí odkaz:
https://doaj.org/article/917fde71ee3a406dbdd2c8728bea3a41
Autor:
Hasan Baysal, Vasiliki Siozopoulou, Hannah Zaryouh, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Erik Fransen, Ines De Pauw, Julie Jacobs, Marc Peeters, Patrick Pauwels, Jan Baptist Vermorken, Evelien Smits, Filip Lardon, Jorrit De Waele, An Wouters
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors that retain their poor prognosis despite recent advances in their standard of care. As the involvement of the immune system against HNSCC development is well-recognized,
Externí odkaz:
https://doaj.org/article/c58e7c1d2db342af9441c51ad1dbe781
Autor:
Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Christophe Hermans, Céline Merlin, Ho Wa Lau, Elly Marcq, Marlies Verschuuren, Winnok H. De Vos, Filip Lardon, Evelien L. J. Smits, Christophe Deben
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 667 (2023)
Auranofin (AF) is a potent, off-patent thioredoxin reductase (TrxR) inhibitor that efficiently targets cancer via reactive oxygen species (ROS)- and DNA damage-mediated cell death. The goal of this study is to enhance the efficacy of AF as a cancer t
Externí odkaz:
https://doaj.org/article/7a155ad553444ac0bd4721cceca973cd
Autor:
Laurie Freire Boullosa, Jinthe Van Loenhout, Christophe Hermans, Ho Wa Lau, Céline Merlin, Elly Marcq, Farnaz Sedigheh Takhsha, Wim Martinet, Guido R. Y. De Meyer, Filip Lardon, Evelien L. J. Smits, Christophe Deben
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2761 (2022)
The antineoplastic activity of the thioredoxin reductase 1 (TrxR) inhibitor, auranofin (AF), has already been investigated in various cancer mouse models as a single drug, or in combination with other molecules. However, there are inconsistencies in
Externí odkaz:
https://doaj.org/article/bf1c62dc6aa04eb0a23e72cc58e42727
Autor:
Jinthe Van Loenhout, Laurie Freire Boullosa, Delphine Quatannens, Jorrit De Waele, Céline Merlin, Hilde Lambrechts, Ho Wa Lau, Christophe Hermans, Abraham Lin, Filip Lardon, Marc Peeters, Annemie Bogaerts, Evelien Smits, Christophe Deben
Publikováno v:
Cells, Vol 10, Iss 11, p 2936 (2021)
Targeting the redox balance of malignant cells via the delivery of high oxidative stress unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a novel reactive oxygen species (ROS)-inducing combination treatment strateg
Externí odkaz:
https://doaj.org/article/fb742ef891dc479883b58c28c9e1e561
Autor:
Christophe Deben, Maxim Le Compte, Vasiliki Siozopoulou, Hilde Lambrechts, Christophe Hermans, Ho Wa Lau, Manon Huizing, Kevin Lamote, Jeroen M. H. Hendriks, Peter Van Dam, Patrick Pauwels, Evelien L. J. Smits, Marc Peeters, Filip Lardon
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4074
Cancers
Cancers
In this study, we aimed to study the expression of SARS-CoV-2-related surface proteins in non-small-cell lung cancer (NSCLC) cells and identify clinicopathological characteristics that are related to increased membranous (m)ACE2 protein expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1a4acb81a5fc2efc911d6eef3d85c0
Autor:
Christophe Deben, Jinthe Van Loenhout, Ho Wa Lau, Annemie Bogaerts, Marc Peeters, Abraham Lin, Christophe Hermans, Delphine Quatannens, Evelien Smits, Jorrit De Waele, Laurie Freire Boullosa, Hilde A. J. Lambrechts, Céline Merlin, Filip Lardon
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 2936, p 2936 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2936, p 2936 (2021)
Targeting the redox balance of malignant cells via the delivery of high oxidative stress unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a novel reactive oxygen species (ROS)-inducing combination treatment strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2580c441aab3b0ea51bf132eef771933
Autor:
Baysal, Hasan, Siozopoulou, Vasiliki, Zaryouh, Hannah, Hermans, Christophe, Ho Wa Lau, Lambrechts, Hilde, Fransen, Erik, De Pauw, Ines, Jacobs, Julie, Peeters, Marc, Pauwels, Patrick, Vermorken, Jan Baptist, Smits, Evelien, Lardon, Filip, De Waele, Jorrit, Wouters, An
Publikováno v:
Frontiers in Immunology; 10/4/2022, Vol. 13, p1-18, 18p