Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Ho Jae Han"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 8, Pp 1691-1702 (2024)
Abstract Although the role of gut microbiota (GMB)-derived metabolites in mitochondrial and endolysosomal dysfunction in Alzheimer’s disease (AD) under metabolic syndrome remains unclear, deciphering these host–metabolite interactions represents
Externí odkaz:
https://doaj.org/article/fca3e0a41ab246b5b49978c8380c3c6b
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115759- (2023)
Mesenchymal stem cell (MSC) transplantation offers significant potential for the treatment of diabetes mellitus (DM) and its complications. However, hyperglycemic conditions can induce senescence and dysfunction in both transplanted and resident MSCs
Externí odkaz:
https://doaj.org/article/9f9269aa09ae4b17ae56c399c1bf7643
Publikováno v:
Redox Biology, Vol 65, Iss , Pp 102821- (2023)
Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer’s disease (AD) by inc
Externí odkaz:
https://doaj.org/article/54cb831095ff412e94a4c8dfe1d523ad
Autor:
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the stress-inducing level of glucocorticoid triggers mitochondrial dysfunction including defective mito
Externí odkaz:
https://doaj.org/article/422194e5168342678d3b895f3dab2f57
Autor:
Young Hyun Jung, Chang Woo Chae, Gee Euhn Choi, Him Cha Shin, Jae Ryong Lim, Han Seung Chang, Joonmo Park, Ji Hyeon Cho, Mo Ran Park, Hyun Jik Lee, Ho Jae Han
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-17 (2022)
Abstract Background Androgenetic alopecia (AGA) is a genetic disorder caused by dihydrotestosterone (DHT), accompanied by the senescence of androgen-sensitive dermal papilla cells (DPCs) located in the base of hair follicles. DHT causes DPC senescenc
Externí odkaz:
https://doaj.org/article/2088e48484e64be4b2de3229faf06845
Autor:
Jae Ryong Lim, Chang Woo Chae, Ji Yong Park, Young Hyun Jung, Jee Hyeon Yoon, Min Jeong Kim, Hyun Jik Lee, Gee Euhn Choi, Ho Jae Han
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 106009- (2023)
Heavy alcohol consumption causes neuronal cell death and cognitive impairment. Neuronal cell death induced by ethanol may result from increased production of the sphingolipid metabolite ceramide. However, the molecular mechanisms of neuronal cell dea
Externí odkaz:
https://doaj.org/article/941482575f4f4fcab6d790891c5eef29
Autor:
Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee, Ho Jae Han
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are associated with apoptosis
Externí odkaz:
https://doaj.org/article/303fd4dcf5934b5eac40c8ebc69dc733
Autor:
Gee Euhn Choi, Hyun Jik Lee, Chang Woo Chae, Ji Hyeon Cho, Young Hyun Jung, Jun Sung Kim, Seo Yihl Kim, Jae Ryong Lim, Ho Jae Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that ca
Externí odkaz:
https://doaj.org/article/2cac894c75774d089073e5f07a58c03c
Autor:
Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim, Ho Jae Han
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-19 (2020)
Abstract Background Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitochondrial dynamics, cl
Externí odkaz:
https://doaj.org/article/b5445ae6f24f44bb87b0f879d4fc02ad
Autor:
Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han, Sei-Jung Lee
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Abstract Background Melatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal mucin (Muc) production d
Externí odkaz:
https://doaj.org/article/add30e7863714019b957c480ef05e489