Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles

Autor: Yun Lan, Sophie Wilhelmina van Leur, Julia Ayano Fernando, Ho Him Wong, Martin Kampmann, Lewis Siu, Jingshu Zhang, Mingyuan Li, John M. Nicholls, Sumana Sanyal

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Infection by many (+)RNA viruses is accompanied by ER-expansion and membrane remodelling to form viral replication organelles, followed by assembly and secretion of viral progenies. We previously identified that virus-triggered lipophagy was

Externí odkaz: https://doaj.org/article/06e25eb0898c4aafac875ea13a542e65

MDCK-B4GalNT2 cells disclose a α2,3-sialic acid requirement for the 2009 pandemic H1N1 A/California/04/2009 and NA aid entry of A/WSN/33

Autor: Ho Him Wong, Kevin Fung, John M. Nicholls

Publikováno v: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1428-1437 (2019)

ABSTRACTSwitching of receptor binding preference has been widely considered as one of the necessary mutations for avian influenza viruses, enabling efficient transmissions between human hosts. By stably overexpressing B4GalNT2 gene in MDCK cells, sur

Externí odkaz: https://doaj.org/article/99ac6025b7a643f2aa46b210883fd969

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

Autor: Qi Wen Teo, Adolfo García-Sastre, Leo L.M. Poon, Ho Him Wong, Caroline Demeret, Agathe Le Quang, Artejan te Velthuis, Akhee Sabiha Jahan, Elise Biquand, Alex W.H. Chin, Sumana Sanyal, Sophie A. Valkenburg, Chris Ka Pun Mok, Raquel Muñoz-Moreno

Publikováno v: Cell Reports, Vol 30, Iss 5, Pp 1570-1584.e6 (2020)
Cell Reports
Cell Reports, Elsevier Inc, 2020, 30 (5), pp.1570-1584.e6. ⟨10.1016/j.celrep.2020.01.015⟩
Cell Reports, 2020, 30 (5), pp.1570-1584.e6. ⟨10.1016/j.celrep.2020.01.015⟩

Summary: Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate this pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7749df9e39d91346d4bcd3b64399959a
http://www.sciencedirect.com/science/article/pii/S2211124720300243

Effect of overexpression of B4GalNT2 in MDCK on influenza viral infection

Autor: Ho-him Wong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a3a7948b21b660778c29de82bed86ae
https://doi.org/10.5353/th_991044058295203414

OTUB1 is a key regulator of RIG-I dependent immune signalling and is targeted for proteasomal degradation by influenza A NS1

Autor: Chris Ka Pun Mok, Qi Wen Teo, Sumana Sanyal, Sophie Doak, Caroline Demeret, Leo L.M. Poon, Akhee Sabiha Jahan, Artejan te Velthuis, Raquel Muñoz-Moreno, Elise Biquand, Alex W.H. Chin, Ho Him Wong, Agathe Le Quang, Adolfo García-Sastre

SummaryDeubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host innate immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, DUBs that regulate this pathway have not been ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d462aa27ee57c6b061e963f8f86813c5