The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9.

Autor: Bayly-Jones C; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, Australia., Ho BHT; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Lau C; Research laboratory, Nordland Hospital Trust, Bodø, Norway., Leung EWW; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., D'Andrea L; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Lupton CJ; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Ekkel SM; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Venugopal H; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, 3800, VIC, Australia., Whisstock JC; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, Australia.; EMBL Australia, Monash University, Melbourne, VIC, 3800, Australia., Mollnes TE; Research laboratory, Nordland Hospital Trust, Bodø, Norway.; Institute of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway., Spicer BA; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia. bradley.spicer@monash.edu.; ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Melbourne, Australia. bradley.spicer@monash.edu., Dunstone MA; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia. michelle.dunstone@monash.edu.

Publikováno v: Communications biology [Commun Biol] 2023 Jan 13; Vol. 6 (1), pp. 42. Date of Electronic Publication: 2023 Jan 13.