Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study

Autor: Li, Bryan K., Vasiljevic, Alexandre, Dufour, Christelle, Yao, Fupan, Ho, Ben L. B., Lu, Mei, Hwang, Eugene I., Gururangan, Sridharan, Hansford, Jordan R., Fouladi, Maryam, Nobusawa, Sumihito, Laquerriere, Annie, Delisle, Marie-Bernadette, Fangusaro, Jason, Forest, Fabien, Toledano, Helen, Solano-Paez, Palma, Leary, Sarah, Birks, Diane, Hoffman, Lindsey M., Szathmari, Alexandru, Fan, Xing, Catchpoole, Daniel, Zhou, Li, Schultz, Kris Ann P., Ichimura, Koichi, Gauchotte, Guillaume, Jabado, Nada, Jones, Chris, Loussouarn, Delphine, Mokhtari, Karima, Rousseau, Audrey, Ziegler, David S., Tanaka, Shinya, Pomeroy, Scott L., Gajjar, Amar, Ramaswamy, Vijay, Hawkins, Cynthia, Grundy, Richard G., Hill, D. Ashley, Bouffet, Eric, Huang, Annie, Jouvet, Anne

Pineoblastomas (PBs) are rare, aggressive pediatric brain tumors of the pineal gland with modest overall survival despite intensive therapy. We sought to define the clinical and molecular spectra of PB to inform new treatment approaches for this orph

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Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study.

Autor: Li BK; Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave., 10421B, Black, Toronto, ON, M5G 1X8, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Vasiljevic A; Faculté de Médecine, Université de Lyon, Lyon, France.; Service d'Anatomie et Cytologie Pathologiques, CHU de Lyon, Lyon, France., Dufour C; Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Villejuif, Paris, France., Yao F; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Ho BLB; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada., Lu M; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada., Hwang EI; Department of Oncology, Children's National Medical Center, Washington, DC, USA., Gururangan S; Department of Pediatrics, Preston A. Wells Jr. Center for Brain Tumor Therapy, UF Health Shands Hospital, University of Florida, Gainesville, FL, USA., Hansford JR; Children's Cancer Centre, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC, Australia., Fouladi M; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nobusawa S; Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan., Laquerriere A; Department of Pathology, Normandy Center for Genomic and Personalized Medicine, Rouen University Hospital, Normandie University, UNIROUEN, Inserm U1245, F 76000, Rouen, France., Delisle MB; CHU de Toulouse, Hôpital Ranguei, Toulouse, France., Fangusaro J; Department of Pediatric Hematology and Oncology, Children's Healthcare of Atlanta and the Emory University School of Medicine, Atlanta, GA, USA., Forest F; Department of Pathology, CHU St. Etienne, Saint-Étienne, France., Toledano H; Department of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel., Solano-Paez P; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Hospital Infantil Virgen del Rocio, Seville, Spain., Leary S; Cancer and Blood Disorders Center, Seattle Children's, Seattle, WA, USA., Birks D; Department of Pediatrics, University of Colorado Denver, Denver, CO, USA., Hoffman LM; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ, USA., Szathmari A; Département de Neurochirurgie Adulte et Pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France., Faure-Conter C; Institut d'Hématologie et d'Oncologie Pédiatrique, IHOPe, Lyon, France., Fan X; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA., Catchpoole D; Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead, NSW, Australia., Zhou L; Children's Cancer Research Unit, The Children's Hospital at Westmead, Westmead, NSW, Australia., Schultz KAP; Cancer and Blood Disorder, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, USA., Ichimura K; National Cancer Centre Research Institute, Tokyo, Japan., Gauchotte G; Department of Pathology, CHU Nancy, Nancy, France., Jabado N; Departments of Pediatrics and Human Genetics, McGill University, Montreal, QC, Canada., Jones C; The Institute of Cancer Research, London, UK., Loussouarn D; Service d'Anatomie et de Cytologie pathologiques, CHU Nantes, Nantes, France., Mokhtari K; Département de Neuropathologie, Hôpital Universitaire Pitie-Salpetriere, Paris, France., Rousseau A; Département de Pathologie Cellulaire et Tissulaire, CHU d'Angers, Angers, France., Ziegler DS; Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Centre, University of New South Wales, Sydney, NSW, Australia., Tanaka S; Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, Hokkaido, Japan., Pomeroy SL; Department of Neurology, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA., Gajjar A; Department of Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Ramaswamy V; Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave., 10421B, Black, Toronto, ON, M5G 1X8, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hawkins C; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada., Grundy RG; Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK., Hill DA; Division of Pathology, Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC, USA., Bouffet E; Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave., 10421B, Black, Toronto, ON, M5G 1X8, Canada., Huang A; Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave., 10421B, Black, Toronto, ON, M5G 1X8, Canada. annie.huang@sickkids.ca.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada. annie.huang@sickkids.ca.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. annie.huang@sickkids.ca.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. annie.huang@sickkids.ca., Jouvet A; Service d'Anatomie et Cytologie Pathologiques, CHU de Lyon, Lyon, France.; Pathology and Molecular Biology, SFCE, Bordeaux, France.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2020 Feb; Vol. 139 (2), pp. 223-241. Date of Electronic Publication: 2019 Dec 09.