Zobrazeno 1 - 10
of 546
pro vyhledávání: '"Hnf4α"'
Autor:
Céline Van Dender, Steven Timmermans, Ville Paakinaho, Tineke Vanderhaeghen, Jolien Vandewalle, Maarten Claes, Bruno Garcia, Bart Roman, Jan De Waele, Siska Croubels, Karolien De Bosscher, Philip Meuleman, Antoine Herpain, Jorma J Palvimo, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2485-2515 (2024)
Abstract In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free f
Externí odkaz:
https://doaj.org/article/a06f4ebf50eb4404b264053ba4838ecb
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundHepatocyte nuclear factor 4 alpha (HNF4α) is the master regulator of hepatic differentiation. Recent studies have also revealed the role of HNF4α in hepatocyte proliferation via negatively regulating the expression of proto-mitogenic gene
Externí odkaz:
https://doaj.org/article/aac9269bc8e24f43a2f589beecdc3d06
Publikováno v:
مجله علمی دانشگاه علوم پزشکی کردستان, Vol 28, Iss 4, Pp 1-11 (2023)
Background and Aim: Retinoic acid (RA) is involved in protecting the intestinal barrier, inducing differentiation, growth and proliferation of epithelial cells. There are several hypotheses about the mechanism of induction of apoptosis by RA, but few
Externí odkaz:
https://doaj.org/article/2e1b2a2cfeac4cc9aa97d0619dcc0fbd
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115923- (2023)
HNF4α, a transcription factor, plays a vital role in regulating functional genes and biological processes. Its alternative splicing leads to various transcript variants encoding different isoforms. The spotlight has shifted towards the extensive dis
Externí odkaz:
https://doaj.org/article/b2a28a45d2c44103a58605faf3fd4b0c
Autor:
Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101821- (2023)
The disease progression of the metabolic syndrome is associated with prolonged hyperlipidemia and insulin resistance, eventually giving rise to impaired insulin secretion, often concomitant with hypoadiponectinemia. As an adipose tissue derived hormo
Externí odkaz:
https://doaj.org/article/2a4c59c398c7494fb3ba2aafae8e0020
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 5, Pp 724-732 (2023)
Objective To explore the potential application of the intrahepatic cholangiocyte organoid (ICO) differentiation model to study liver development. Methods Combining CRISPR/Cas9 gene editing technology and ICO differentiation model, bulk RNA-seq data o
Externí odkaz:
https://doaj.org/article/bfd5f7659025407f98c82f1f3c091a17
Autor:
Sheng Shen, Ran Yan, Zhanglian Xie, Xiaoyang Yu, Hongyan Liang, Qiuhong You, Hu Zhang, Jinlin Hou, Xiaoyong Zhang, Yuanjie Liu, Jian Sun, Haitao Guo
Publikováno v:
Viruses, Vol 16, Iss 6, p 890 (2024)
Tripartite motif (TRIM) proteins, comprising a family of over 100 members with conserved motifs, exhibit diverse biological functions. Several TRIM proteins influence viral infections through direct antiviral mechanisms or by regulating host antivira
Externí odkaz:
https://doaj.org/article/256b3eafdc7d4d658498365159f415d5
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21267- (2023)
Ethanol (EtOH) is most widely used in alcoholic beverages to prepare alcohol. As EtOH is mainly metabolised in the liver, the excessive consumption of EtOH forms a primary toxic metabolic product called acetaldehyde, as the gradual increase in acetal
Externí odkaz:
https://doaj.org/article/52e707f627b44a18b10392afff7dc517
Autor:
Fraydoon Rastinejad
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a multi-faceted nuclear receptor responsible for governing the development and proper functioning of liver and pancreatic islet cells. Its transcriptional functions encompass the regulation of vital metab
Externí odkaz:
https://doaj.org/article/16a20076b3774edf8eca3aa0bbcfdc27
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 3, Pp 593-612 (2023)
Background & Aims: The intestinal epithelium intrinsically renews itself ex vivo via the proliferation of Lgr5+ intestinal stem cells, which is sustained by the establishment of an epithelial stem cell niche. Differentiated Paneth cells are the main
Externí odkaz:
https://doaj.org/article/9812f1aa7a164eb08dcf95ae20cb6916