Zobrazeno 1 - 10
of 16 387
pro vyhledávání: '"Hmg coa"'
Autor:
Sen Lin, Huimin Zhang, Ruiqi Zhao, Zhulin Wu, Weiqing Zhang, Mengjiao Yu, Bei Zhang, Lanyue Ma, Danfei Li, Lisheng Peng, Weijun Luo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Distant metastasis is the leading cause of cancer-related mortality, and achieving survival benefits through advancements in systemic therapy remains challenging. Mast cells play a dual role in shaping the tumor microenvironment (TME) and in
Externí odkaz:
https://doaj.org/article/349504a4f65e463fb56b1dba0ee91d87
Publikováno v:
Journal of Human, Earth, and Future, Vol 5, Iss 3, Pp 348-365 (2024)
Lime peels are rich in flavonoids, alkaloids, phenols, saponins, and tannins, exhibiting antibacterial, antioxidant, anti-inflammatory, anti-hypertensive, and anti-hypercholesterolemia properties. However, the specific active constituents of Acehnese
Externí odkaz:
https://doaj.org/article/df387d38133249ef9b98384f11973701
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 10130-10139 (2024)
Statins inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, and reduce cholesterol synthesis. They also have been demonstrated to improve prognosis in patients with various cancers, suggesting
Externí odkaz:
https://doaj.org/article/fe01477cf19940c2bb9edb5c33428509
Autor:
Braun Andreas Albert, Atiya Monika, Göhner Katja, Hortobagyi Tibor, Burkhardt Tobias, Schreiner Bettina
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 1541-7 (2024)
Statin use can lead to various muscle-related issues, including benign creatine kinase (CK) elevations, myalgias, toxic myopathies, rhabdomyolysis, and immune-mediated necrotizing myositis (IMNM), which primarily affects older males. IMNM presents wi
Externí odkaz:
https://doaj.org/article/23b6c2e2b163427788bdc05df33eb614
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 41, Iss , Pp 101153- (2024)
Background: Elevated plasma levels of 3-hydroxyisovaleryl-carnitine (C5OH) and impaired leucine catabolism are frequently observed in newborn screening reports, necessitating consideration of various diseases in the differential diagnosis. This study
Externí odkaz:
https://doaj.org/article/be18bc5789b14f158f80e92a59e8ddc1
Autor:
Rishav Mazumder, Deijy Choudhury, Alekhya Sarkar, Ashmita Ghosh, Sudhan Debnath, Bimal Debnath, Rajat Ghosh
Publikováno v:
Aspects of Molecular Medicine, Vol 4, Iss , Pp 100053- (2024)
Cardiovascular disease is estimated to be responsible for one-third of all global deaths annually. It occurs mostly due to hyperlipidemia, a condition where excessive cholesterol deposits in blood vessels. A favorable target for treating hyperlipidem
Externí odkaz:
https://doaj.org/article/02fac143382f4b31ba421fc57c2070e8
Publikováno v:
Journal of Taibah University for Science, Vol 18, Iss 1 (2024)
Currently, various heart conditions, such as hyperlipidaemia, are causing fear among people worldwide. In this research, silver nanoparticles (AgNPs) were produced using Emblica Officinallis leaf extract (EOLE). The synthesis of EOLEAgNPs was examine
Externí odkaz:
https://doaj.org/article/8ebaac65258246ef95f6f6f9e3f9c351
Autor:
Hemant Mistry, Connor D. Richardson, Adrian Higginbottom, Bridget Ashford, Saif U. Ahamed, Zoe Moore, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton
Publikováno v:
Neuroscience Research, Vol 204, Iss , Pp 22-33 (2024)
Altered cholesterol metabolism is implicated in brain ageing and Alzheimer’s disease. We examined whether key genes regulating cholesterol metabolism and levels of brain cholesterol are altered in dementia and Alzheimer’s disease neuropathologica
Externí odkaz:
https://doaj.org/article/1d219fbbc8fe4277b0a2402b044a5f7e
Autor:
Kazuhito Iguchi, Yasuto Yamamoto, Masateru Uchiyama, Hisanori Masaoka, Masahiro Nakamura, Hiroyuki Shizuka, Tomohiro Imazuru, Tomoki Shimokawa
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background We previously demonstrated that the hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor (statins) play an important role in the regulation of alloimmune responses. However, little is known regarding the effects of statin on al
Externí odkaz:
https://doaj.org/article/d1c3e69bbb1148fcaa9a580f04a4965a
Autor:
Kang Qu, Ming-xi Li, Peng Yu, International Headache Genetics Consortium, Bai-hua Wu, Miao Shi, Ming Dong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic instruments as proxie
Externí odkaz:
https://doaj.org/article/fc4c4dca89f446298111e8cbe752cc7f