Sodium, Potassium-Adenosine Triphosphatase as a Potential Target of the Anti-Tuberculosis Agents, Clofazimine and Bedaquiline.

Autor: Mmakola K; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa., Balmith M; Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africa., Steel H; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa., Said M; Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Services, Pretoria 0001, South Africa., Potjo M; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Services, Pretoria 0002, South Africa., van der Mescht M; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa., Hlatshwayo N; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Services, Pretoria 0002, South Africa., Meyer P; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Services, Pretoria 0002, South Africa., Tintinger G; Department of Internal Medicine, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Pretoria 0002, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Clinical and Translational Research Unit of the Rosebank, Oncology Centre, Johannesburg 2196, South Africa., Cholo M; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.; Basic and Translational Research Unit, Nuclear Medicine Research Infrastructure, Steve Biko Academic Hospital, Pretoria 0001, South Africa.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 04; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 04.

Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3.

Autor: Rapoport BL; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Medical Oncology Centre of Rosebank, Johannesburg, South Africa.; Netcare Breast Care Centre, Johannesburg, South Africa., Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Benn CA; Netcare Breast Care Centre, Johannesburg, South Africa.; Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Nayler S; Netcare Breast Care Centre, Johannesburg, South Africa.; Drs Gritzman & Thatcher Inc. Laboratories, University of the Witwatersrand Donald Gordon Medical Centre, Johannesburg, South Africa., Smit T; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Heyman L; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Theron AJ; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Hlatshwayo N; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Kwofie LLI; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Meyer PWA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division of the National Health Laboratory Service, Pretoria, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Mar 30; Vol. 13, pp. 1097309. Date of Electronic Publication: 2023 Mar 30 (Print Publication: 2023).

Systemic Immune Dysregulation in Early Breast Cancer Is Associated With Decreased Plasma Levels of Both Soluble Co-Inhibitory and Co-Stimulatory Immune Checkpoint Molecules.

Autor: Rapoport BL; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Steel HC; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Hlatshwayo N; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa., Theron AJ; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Meyer PWA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa., Nayler S; Drs Gritzman & Thatcher Inc. Laboratories, Johannesburg, South Africa.; University of the Witwatersrand Donald Gordon Medical Centre, Johannesburg, South Africa., Benn CA; Netcare Breast Care Centre, Johannesburg, South Africa., Smit T; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Kwofie LLI; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Department of Immunology, Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa., Heyman L; Medical Oncology Centre of Rosebank, Johannesburg, South Africa., Anderson R; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 May 23; Vol. 13, pp. 823842. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).

BODIPY dyes for optical limiting applications on the nanosecond timescale.

Autor: Mack, John, Kubheka, Gugu, May, Aviwe, Ngoy, Bokolombe P., Nyokong, Tebello

Publikováno v: Dalton Transactions: An International Journal of Inorganic Chemistry; 11/28/2024, Vol. 53, p17766-17771, 6p

Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion.

Autor: Bruss, Christina¹ (AUTHOR) christina.bruss@ukr.de, Kellner, Kerstin¹ (AUTHOR) sseitz@csj.de, Albert, Veruschka¹ (AUTHOR) oortmann@csj.de, Hutchinson, James A.² (AUTHOR) james.hutchinson@ukr.de, Seitz, Stephan¹ (AUTHOR) gero.brockhoff@ukr.de, Ortmann, Olaf¹ (AUTHOR), Brockhoff, Gero¹ (AUTHOR), Wege, Anja K.¹ (AUTHOR) anja.wege@ukr.de

Publikováno v: Cancers. May2023, Vol. 15 Issue 9, p2615. 19p.