Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines

Autor: Jack H, Lai, Wengen, Wu, Yuhong, Zhou, Hlaing H, Maw, Yuxin, Liu, Lawrence J, Milo, Sarah E, Poplawski, Gillian D, Henry, James L, Sudmeier, David G, Sanford, William W, Bachovchin

Publikováno v: Journal of medicinal chemistry. 50(10)

We describe here the epimerization-free synthesis and characterization of a new class of conformationally constrained lactam aminoboronic acid inhibitors of dipeptidyl peptidase IV (DPP IV; E.C. 3.4.14.5). These compounds have the advantage that they

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb8509edb149b97ece0d65c13debc858
https://pubmed.ncbi.nlm.nih.gov/17458948

Biotransformation research advances - 2023 year in review.

Autor: Khojasteh SC; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Argikar UA; Non-clinical Development, Bill and Melinda Gates Medical Research Institute, Cambridge, MA, USA., Chatzopoulou M; Early Clinical Development and Translational Science, UCB Biopharma UK, Slough, UK., Cheruzel L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Cho S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Dhaware D; DMPK and Safety Sciences, Orion Pharma, Espoo, Finland., Johnson KM; Drug Metabolism and Pharmacokinetics, Inotiv, MD Heights, MO, USA., Kalgutkar AS; Medicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., Liu J; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Ma B; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Maw H; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA., Rowley JA; Early Clinical Development and Translational Science, UCB Biopharma UK, Slough, UK., Seneviratne HK; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA., Wang S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA.

Publikováno v: Drug metabolism reviews [Drug Metab Rev] 2024 Jul 11, pp. 1-33. Date of Electronic Publication: 2024 Jul 11.

Biotransformation research advances - 2022 year in review.

Autor: Khojasteh SC; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Argikar UA; Non-clinical Development, Bill and Melinda Gates Medical Research Institute, Cambridge, MA, USA., Cheruzel L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Cho S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Crouch RD; Department of Pharmacy and Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Nashville, TN, USA., Dhaware D; DMPK and Safety Sciences, Orion Pharma, Espoo, Finland., Heck CJS; Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USA., Johnson KM; Drug Metabolism and Pharmacokinetics, Inotiv, MD Heights, MO, USA., Kalgutkar AS; Medicine Design, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA., King L; Quantitative Drug Discovery, UCB Biopharma UK, Slough UK., Liu J; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Ma B; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Maw H; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA., Miller GP; Department of Biochemistry and Molecular Biology, University of AR for Medical Sciences, Little Rock, AR, USA., Seneviratne HK; Department of Chemistry and Biochemistry, University of Maryland, Baltimore, MD, USA., Takahashi RH; Drug Metabolism and Pharmacokinetics, Denali Therapeutics, South San Francisco, CA, USA., Wang S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc, South San Francisco, CA, USA., Wei C; Drug Metabolism and Pharmacokinetics, Biogen Inc, Cambridge, MA, USA., Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.

Publikováno v: Drug metabolism reviews [Drug Metab Rev] 2023 Nov; Vol. 55 (4), pp. 301-342. Date of Electronic Publication: 2023 Oct 28.

Chemical and biological evaluation of dipeptidyl boronic acid proteasome inhibitors for use in prodrugs and pro-soft drugs targeting solid tumors.

Autor: Milo LJ Jr; Department of Biochemistry, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, United States., Lai JH, Wu W, Liu Y, Maw H, Li Y, Jin Z, Shu Y, Poplawski SE, Wu Y, Sanford DG, Sudmeier JL, Bachovchin WW

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Jul 14; Vol. 54 (13), pp. 4365-77. Date of Electronic Publication: 2011 Jun 20.