Temozolomide and the PARP Inhibitor Niraparib Enhance Expression of Natural Killer Group 2D Ligand ULBP1 and Gamma-Delta T Cell Cytotoxicity in Glioblastoma.

Autor: Jones AB; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Tuy K; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Hawkins CC; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Quinn CH; Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Saad J; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Gary SE; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Beierle EA; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA., Ding L; In8Bio, Inc., New York, NY 10118, USA., Rochlin KM; In8Bio, Inc., New York, NY 10118, USA., Lamb LS; In8Bio, Inc., New York, NY 10118, USA., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Publikováno v: Cancers [Cancers (Basel)] 2024 Aug 15; Vol. 16 (16). Date of Electronic Publication: 2024 Aug 15.

Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells.

Autor: Hawkins CC; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Jones AB; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Gordon ER; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Harsh Y; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Ziebro JK; Graduate Biomedical Sciences, Division of Neuropathology, Department of Pathology, O'Neal Comprehensive Cancer Center, University of Alabama School of Medicine, Birmingham, AL, USA., Willey CD; Department of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB-SOM), Birmingham, AL, USA., Griguer C; Free Radical & Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA., Crossman DK; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Cooper SJ; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Ramanadham S; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.; Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL, USA., Doan N; Baptist South Medical Center, Montgomery, AL, USA., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. hjelmea@uab.edu.

Publikováno v: Cell death discovery [Cell Death Discov] 2023 Dec 12; Vol. 9 (1), pp. 451. Date of Electronic Publication: 2023 Dec 12.

PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4.

Autor: Marayati R; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Julson J; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Bownes LV; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Quinn CH; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Stafman LL; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Beierle AM; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Markert HR; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Hutchins SC; Division of Pediatric Hematology Oncology, Department of Pediatrics, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Stewart JE; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Crossman DK; Department of Genetics, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 35233, Birmingham, AL, USA., Mroczek-Musulman E; Department of Pathology, The Children's Hospital of Alabama, 35233, Birmingham, AL, USA., Beierle EA; Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 35233, Birmingham, AL, USA. elizabeth.beierle@childrensal.org.; 1600 7th Ave South Lowder Room 300, 35233, Birmingham, AL, USA. elizabeth.beierle@childrensal.org.

Publikováno v: Clinical & experimental metastasis [Clin Exp Metastasis] 2022 Dec; Vol. 39 (6), pp. 899-912. Date of Electronic Publication: 2022 Oct 31.

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.

Autor: Watson DC; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA.; University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Bayik D; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Storevik S; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Moreino SS; Department of Biomedicine, University of Bergen, Bergen, Norway., Sprowls SA; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Han J; Department of Biomedicine, University of Bergen, Bergen, Norway., Augustsson MT; Department of Biomedicine, University of Bergen, Bergen, Norway., Lauko A; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.; Medical Scientist Training Program, Case Western Reserve University, Cleveland, OH, USA., Sravya P; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Røsland GV; Department of Biomedicine, University of Bergen, Bergen, Norway., Troike K; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Tronstad KJ; Department of Biomedicine, University of Bergen, Bergen, Norway., Wang S; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Sarnow K; Department of Biomedicine, University of Bergen, Bergen, Norway., Kay K; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Lunavat TR; Department of Biomedicine, University of Bergen, Bergen, Norway.; Department of Neurology, Molecular Neurogenetics Unit-West, Massachusetts General Hospital, Boston, MA, USA., Silver DJ; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Dayal S; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Joseph JV; Stipe Therapeutics, Aarhus, Denmark., Mulkearns-Hubert E; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA., Ystaas LAR; Department of Biomedicine, University of Bergen, Bergen, Norway., Deshpande G; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Guyon J; University of Bordeaux, INSERM, BRIC, Pessac, France., Zhou Y; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Magaut CR; University of Bordeaux, INSERM, BRIC, Pessac, France., Seder J; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Neises L; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Williford SE; University of Alabama at Birmingham, Birmingham, AL, USA., Meiser J; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Scott AJ; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Cancer Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA., Mears JA; Case Comprehensive Cancer Center, Cleveland, OH, USA.; School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Bjerkvig R; Department of Biomedicine, University of Bergen, Bergen, Norway.; NorLux Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg., Chakraborty A; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Daubon T; University of Bordeaux, CNRS, IBGC, Bordeaux, France., Cheng F; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Case Comprehensive Cancer Center, Cleveland, OH, USA., Lyssiotis CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Wahl DR; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Hjelmeland AB; University of Alabama at Birmingham, Birmingham, AL, USA., Hossain JA; Department of Biomedicine, University of Bergen, Bergen, Norway., Miletic H; Department of Biomedicine, University of Bergen, Bergen, Norway. hrvoje.miletic@uib.no.; Department of Pathology, Haukeland University Hospital, Bergen, Norway. hrvoje.miletic@uib.no., Lathia JD; Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. lathiaj@ccf.org.; Case Comprehensive Cancer Center, Cleveland, OH, USA. lathiaj@ccf.org.; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA. lathiaj@ccf.org.

Publikováno v: Nature cancer [Nat Cancer] 2023 May; Vol. 4 (5), pp. 648-664. Date of Electronic Publication: 2023 May 11.

α2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth.

Autor: Gc S; Department of Cell, Developmental and Integrative Biology., Tuy K; Department of Cell, Developmental and Integrative Biology., Rickenbacker L; Department of Cell, Developmental and Integrative Biology., Jones R; Department of Cell, Developmental and Integrative Biology., Chakraborty A; Department of Cell, Developmental and Integrative Biology., Miller CR; Department of Pathology., Beierle EA; Department of Surgery, and., Hanumanthu VS; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Tran AN; DataGrata LLC, Chicago, Illinois, USA., Mobley JA; Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Bellis SL; Department of Cell, Developmental and Integrative Biology., Hjelmeland AB; Department of Cell, Developmental and Integrative Biology.

Publikováno v: JCI insight [JCI Insight] 2022 Nov 08; Vol. 7 (21). Date of Electronic Publication: 2022 Nov 08.