Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hjalte M. Larsen"'
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia. Investigation of the α7 receptor is commonly performed in animals but it is critical
Externí odkaz:
https://doaj.org/article/4c47d26e3ec5461d81917c91768aaf0a
Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B
Autor:
Yu Zhang, Benjamin Schmid, Nanett K. Nikolaisen, Mikkel A. Rasmussen, Blanca I. Aldana, Mikkel Agger, Kirstine Calloe, Tina C. Stummann, Hjalte M. Larsen, Troels T. Nielsen, Jinrong Huang, Fengping Xu, Xin Liu, Lars Bolund, Morten Meyer, Lasse K. Bak, Helle S. Waagepetersen, Yonglun Luo, Jørgen E. Nielsen, Bjørn Holst, Christian Clausen, Poul Hyttel, Kristine K. Freude
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 648-658 (2017)
The truncated mutant form of the charged multivesicular body protein 2B (CHMP2B) is causative for frontotemporal dementia linked to chromosome 3 (FTD3). CHMP2B is a constituent of the endosomal sorting complex required for transport (ESCRT) and, when
Externí odkaz:
https://doaj.org/article/ddcff1aabf094e94bc737b7fbb9ee240
Autor:
Boye Schnack Nielsen, Natasha H. Madsen, Jesper Larsen, Hjalte M. Larsen, Monika Gad, Kim Holmstrom
Publikováno v:
Cancer Research. 83:4566-4566
3D cancer cell cultures have enabled new opportunities for replacing compound testing in experimental animals and provide a basis for high content work-flows for drug testing. Here we present data obtained from 3D multicellular tumor spheroids (MCTS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bbf13d26e727654d0738c04c529a3c8
https://doi.org/10.1158/1538-7445.am2023-4566
https://doi.org/10.1158/1538-7445.am2023-4566
Publikováno v:
Larsen, H M, Hansen, S K, Mikkelsen, J D, Hyttel, P & Stummann, T C 2019, ' Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons ', Stem Cell Research, vol. 41, 101642 . https://doi.org/10.1016/j.scr.2019.101642
Stem Cell Research, Vol 41, Iss, Pp-(2019)
Stem Cell Research, Vol 41, Iss, Pp-(2019)
The α7 nicotinic acetylcholine receptor has been extensively researched as a target for treatment of cognitive impairment in Alzheimer's disease and schizophrenia. Investigation of the α7 receptor is commonly performed in animals but it is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10bca329c563395ced9da3d56eb3f0d
https://doi.org/10.1016/j.scr.2019.101642
https://doi.org/10.1016/j.scr.2019.101642
Autor:
Andreas W. Sailer, Hjalte M. Larsen, Kristine Niss Arfelt, Mette M. Rosenkilde, Tau Benned-Jensen, Stephane Laurent, Christian M. Madsen, Christoffer Norn, Thomas M. Frimurer, Romain M. Wolf
Publikováno v:
The Journal of Biological Chemistry
Background: EBI2 was recently deorphanized as the first oxysterol-activated receptor, but the binding mode remains unknown. Results: Mutational analysis showed that substitution of Arg-87, Tyr-112, Tyr-116, and Tyr-260 abolished agonist binding and E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efec2a66815f9907c5c7a0934a465389
http://europepmc.org/articles/PMC3471686
http://europepmc.org/articles/PMC3471686