Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Hiu-Fung Yuen"'
Autor:
Hiu-Fung Yuen, Cian M McCrudden, Yu-Han Huang, Jill M Tham, Xiaoqian Zhang, Qi Zeng, Shu-Dong Zhang, WanJin Hong
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250187 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0054211.].
Externí odkaz:
https://doaj.org/article/7b8830a33a8548cea5c792e17f46688b
Autor:
Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Muhammad Jameel, Yuchen Bai, Hiu-Fung Yuen, Shu-Dong Zhang, Youzhi Zhu, Yao Lin, Hang Fai Kwok
Publikováno v:
Cancers, Vol 10, Iss 9, p 282 (2018)
Breast cancer is one of the most common malignancies in women worldwide. In breast cancer, the cell proliferation rate is known to influence the cancer malignancy. Recent studies have shown that DNA replication initiation/licensing factors are involv
Externí odkaz:
https://doaj.org/article/d0ca930a67bc4889b3e9800f733cd1a1
Autor:
Cian M McCrudden, Martin G O'Rourke, Kim E Cherry, Hiu-Fung Yuen, Declan O'Rourke, Muhammad Babur, Brian A Telfer, Huw D Thomas, Patrick Keane, Thiagarajan Nambirajan, Chris Hagan, Joe M O'Sullivan, Chris Shaw, Kaye J Williams, Nicola J Curtin, David G Hirst, Tracy Robson
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118187 (2015)
Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer treatment. We previously reported that the first PARP inhibitor to enter clinical trial, ru
Externí odkaz:
https://doaj.org/article/0041870469fb4ed7ba5bba882c646e79
Autor:
Hiu-Fung Yuen, Cian M McCrudden, Yu-Han Huang, Jill M Tham, Xiaoqian Zhang, Qi Zeng, Shu-Dong Zhang, WanJin Hong
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54211 (2013)
The Hippo pathway restricts the activity of transcriptional coactivators TAZ (WWTR1) and YAP. TAZ and YAP are reported to be overexpressed in various cancers, however, their prognostic significance in colorectal cancers remains unstudied. The express
Externí odkaz:
https://doaj.org/article/aeb67df3a4114cafa0a492b343604427
Autor:
Hiu‑Fung Yuen, Olga Abramczyk, Grant Montgomery, Ka‑Kui Chan, Yu‑Han Huang, Takehiko Sasazuki, Senji Shirasawa, Srivastava Gopesh, Kwok‑Wah Chan, Dean Fennell, Pasi Janne, Mohamed El‑Tanani, James T. Murray
Publikováno v:
Bioscience Reports, Vol 32, Iss 4 (2012)
Inhibition of the PI3K (phosphoinositide 3-kinase)/Akt/mTORC1 (mammalian target of rapamycin complex 1) and Ras/MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK pathways for cancer therapy has been
Externí odkaz:
https://doaj.org/article/9295872ba0ff442d8eb285982b7d1cf0
Autor:
Mohamed El-Tanani, Philip S. Rudland, Patrick G. Johnston, Dean A. Fennell, Pasi Janne, Ken O'Byrne, Osama Sharaf Eldin, Angela Platt-Higgins, James T. Murray, Claire Grills, Ka-Kui Chan, Hiu-Fung Yuen
Purpose: Cancer cells have been shown to be more susceptible to Ran knockdown than normal cells. We now investigate whether Ran is a potential therapeutic target of cancers with frequently found mutations that lead to higher Ras/MEK/ERK [mitogen-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70067d5af7d41e68e697ef0eda2aca32
https://doi.org/10.1158/1078-0432.c.6520403
https://doi.org/10.1158/1078-0432.c.6520403
Autor:
Mohamed El-Tanani, Philip S. Rudland, Patrick G. Johnston, Dean A. Fennell, Pasi Janne, Ken O'Byrne, Osama Sharaf Eldin, Angela Platt-Higgins, James T. Murray, Claire Grills, Ka-Kui Chan, Hiu-Fung Yuen
PDF file - 3.6K, Cancer cells with K-Ras activation mutation (HCT116/Hkh-2 isogenic pair) are more susceptible to Ran silencing-induced apoptosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d29ff835d261255b4ca4e840b09a77
https://doi.org/10.1158/1078-0432.22445180.v1
https://doi.org/10.1158/1078-0432.22445180.v1
Autor:
Mohamed El-Tanani, Philip S. Rudland, Patrick G. Johnston, Dean A. Fennell, Pasi Janne, Ken O'Byrne, Osama Sharaf Eldin, Angela Platt-Higgins, James T. Murray, Claire Grills, Ka-Kui Chan, Hiu-Fung Yuen
PDF file - 144K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b106164f2577ebe341c7dbcec77b59b
https://doi.org/10.1158/1078-0432.22445168.v1
https://doi.org/10.1158/1078-0432.22445168.v1
Autor:
Mohamed El-Tanani, Philip S. Rudland, Patrick G. Johnston, Dean A. Fennell, Pasi Janne, Ken O'Byrne, Osama Sharaf Eldin, Angela Platt-Higgins, James T. Murray, Claire Grills, Ka-Kui Chan, Hiu-Fung Yuen
PDF file - 1.6MB, Percentage of sub-G1 phase apoptotic MCF10a and MDA MB231 cells grown in serum-containing medium after Ran silencing. (A-B) Cells were infected with shRan1 and shRan2. Medium was changed to serum-free medium (DMEM) 24hr post-infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d1782c7f6e5efb7ea82119caf5be40
https://doi.org/10.1158/1078-0432.22445192.v1
https://doi.org/10.1158/1078-0432.22445192.v1
Autor:
Mohamed El-Tanani, Philip S. Rudland, Patrick G. Johnston, Dean A. Fennell, Pasi Janne, Ken O'Byrne, Osama Sharaf Eldin, Angela Platt-Higgins, James T. Murray, Claire Grills, Ka-Kui Chan, Hiu-Fung Yuen
PDF file - 93K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7e0e10c34b666d8e5b9c9a543e2b7b
https://doi.org/10.1158/1078-0432.22445171.v1
https://doi.org/10.1158/1078-0432.22445171.v1