Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hiu Yeung Lau"'
Autor:
Chong Hui Clara Ong, Dong Yeul Lee, Bernett Lee, Huihua Li, Jeffrey Chun Tatt Lim, Johnathan Xiande Lim, Joe Poh Sheng Yeong, Hiu Yeung Lau, Aye Aye Thike, Puay Hoon Tan, Jabed Iqbal
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background The effect of extracellular microenvironment (hypoxia and pH) has been regarded as a key hallmark in cancer progression. The study aims to investigate the effects of carbonic anhydrase IX (CAIX), a key hypoxia-inducible marker, in
Externí odkaz:
https://doaj.org/article/ee51c9920f174f54b364a33da90920b8
Publikováno v:
Asian Journal of Surgery, Vol 45, Iss 1, Pp 613-615 (2022)
Externí odkaz:
https://doaj.org/article/2b7c490de5bf4e3ba1a196dacca99d7b
Publikováno v:
Asian Journal of Surgery, Vol 45, Iss 1, Pp 613-615 (2022)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15326893d97dbcfcbaf8c9cc59f8fb74
https://doi.org/10.1016/j.asjsur.2021.10.006
https://doi.org/10.1016/j.asjsur.2021.10.006
Publikováno v:
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 807, p 807 (2021)
Volume 13
Issue 4
Cancers, Vol 13, Iss 807, p 807 (2021)
Simple Summary Anchorage-independent soft agar colony formation assays have been widely used as an in vitro surrogate for in vivo tumour formation in xenograft studies, and has found much utility in studies such as cancer drug development. However, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24573f146f53b940f3d1ea3ffb0be8be
http://europepmc.org/articles/PMC7919038
http://europepmc.org/articles/PMC7919038
Publikováno v:
Oncogene
Despite extensive effort, there has been limited progress in the development of direct RAS inhibitors. Targeting isoprenylcysteine carboxylmethyltransferase (ICMT), a unique enzyme of RAS post-translational modification, represents a promising strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c6697800dc434b9e3caf28f2e38b5c
https://doi.org/10.1038/onc.2016.508
https://doi.org/10.1038/onc.2016.508
Autor:
Mei Wang, Hiu Yeung Lau
Publikováno v:
Small GTPases
Mutant RAS isoforms are the most common oncogenes affecting human cancers. After decades of effort in developing drugs targeting oncogenic RAS-driven cancers, we are still charting an unclear path. Despite recent developments exemplified by KRAS (G12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73da5c173d28e83dce3e32ae005a7ac5
https://europepmc.org/articles/PMC7549710/
https://europepmc.org/articles/PMC7549710/
Publikováno v:
Cancer Research. 77:1371-1371
Purpose Limited progress has been made in the development of direct inhibitors of Ras. Therefore, targeting isoprenylcysteine carboxylmethyltransferase (ICMT), the final enzyme in the prenylation pathway for Ras and other proteins containing the so-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f4b13c404c78f2b9185dcdcb4febda
https://doi.org/10.1158/1538-7445.am2017-1371
https://doi.org/10.1158/1538-7445.am2017-1371
Autor:
Melissa Wirawan, Tianming Yang, Dianyan Guo, Hiu Yeung Lau, Mei-Lin Go, Pondy Murugappan Ramanujulu, Patrick J. Casey, Mei Wang
Publikováno v:
Cancer biologytherapy. 15(9)
Inhibitors of isoprenylcysteine carboxylmethyltransferase (Icmt) are promising anti-cancer agents, as modification by Icmt is an essential component of the protein prenylation pathway for a group of proteins that includes Ras GTPases. Cysmethynil, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1c9e87e3859d819e517a258450bf2c
https://pubmed.ncbi.nlm.nih.gov/24971579
https://pubmed.ncbi.nlm.nih.gov/24971579
Autor:
Hiu Yeung Lau, Ramanujulu, Pondy M., Dianyan Guo, Tianming Yang, Wirawan, Pondy M., Casey, Patrick J., Mei-Lin Go, Mei Wang
Publikováno v:
Cancer Biology & Therapy; Sep2014, Vol. 15 Issue 9, p1280-1291, 12p
Autor:
McFarlane, Craig, Gu Zi Hui, Wong Zhi Wei Amanda, Hiu Yeung Lau, Lokireddy, Sudarsanareddy, Ge XiaoJia, Mouly, Vincent, Butler-Browne, Gillian, Gluckman, Peter D., Sharma, Mridula, Kambadur, Ravi
Publikováno v:
American Journal of Physiology: Cell Physiology; Jul2011, Vol. 301 Issue 1, pC195-C203, 8p